Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jim Erdei"'
Autor:
Menelas N. Pangalos, Jonathan A. Bard, Michael S. Malamas, Yinfa Yan, Jim Turner, Matthew D. Johnson, Ping Zhou, William Ronald Solvibile, Kristi Fan, Albert J. Robichaud, Yu Hui, Iwan Gunawan, Rajiv Chopra, Jim Erdei, Keith D. Barnes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5164-5170
The proteolytic enzyme β-secretase (BACE1) plays a central role in the synthesis of the pathogenic β-amyloid in Alzheimer’s disease. SAR studies of the S2′ region of the BACE1 ligand binding pocket with pyrazolyl and thienyl P2′ side chains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bbe4bd7a52c542e44404a3661ff400
https://doi.org/10.1016/j.bmcl.2011.07.057
https://doi.org/10.1016/j.bmcl.2011.07.057
Autor:
Steve Jacobsen, Peter H. Reinhart, Albert J. Robichaud, William Ronald Solvibile, Michael S. Malamas, Jim Turner, Koi Michele Morris, Andrea Olland, Ping Zhou, Kristi Fan, Jim Erdei, Menelas N. Pangalos, David Riddell, Dominick Anthony Quagliato, Erik Wagner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6597-6605
The identification of small molecule aminohydantoins as potent and selective human β-secretase inhibitors is reported. These analogs exhibit good brain permeability (40-70%), low nanomolar potency for BACE1, and demonstrate >100-fold selectivity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17719aeaede49b88c03aa1d414605290
https://doi.org/10.1016/j.bmcl.2010.09.029
https://doi.org/10.1016/j.bmcl.2010.09.029
Autor:
Jonathan A. Bard, Michael S. Malamas, Kristi Fan, Andrea Olland, Albert J. Robichaud, Erik Wagner, Yun Hu, Yu Hui, Iwan Gunawan, Jim Turner, Matthew R. Johnson, Jim Erdei, Keith D. Barnes
Publikováno v:
Journal of Medicinal Chemistry. 52:6314-6323
The identification of small molecule aminoimidazoles as potent and selective human beta-secretase inhibitors is reported. These analogues demonstrate low nannomolar potency for BACE1 in a FRET assay, exhibit comparable activity in a cell-based (ELISA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aded807991850e84a3d1ebc0b011df4
https://doi.org/10.1021/jm9006752
https://doi.org/10.1021/jm9006752
Autor:
Andrea Olland, Rajiv Chopra, Iwan Gunawan, Jonathan A. Bard, Erik Wagner, Yun Hu, Steve Jacobsen, Ronald L. Magolda, Menelas N. Pangalos, Kristi Fan, Jim Erdei, Albert J. Robichaud, Jim Turner, Michael S. Malamas
Publikováno v:
Journal of medicinal chemistry. 53(3)
The identification of small molecule aminohydantoins as potent and selective human beta-secretase inhibitors is reported. These analogues exhibit low nannomolar potency for BACE1, show comparable activity in a cell-based (ELISA) assay, and demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7326165189273a6ae0bf94978b592f20
https://pubmed.ncbi.nlm.nih.gov/19968289
https://pubmed.ncbi.nlm.nih.gov/19968289
Autor:
Jonathan A. Bard, David Riddell, Erik Wagner, Tom Comery, Michael S. Malamas, Kristi Fan, Iwan Gunawan, Magid Abou-Gharbia, Albert J. Robichaud, Peter H. Reinhart, Rajiv Chopra, Jim Erdei, Ron Magolda, Suzan Aschmies, Yun Hu, Menelas N. Pangalos, Jim Turner, Steve Jacobsen
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911ad2fc5eea6fa9a728b219c7c1f3fc
https://doi.org/10.1016/j.jalz.2008.05.1559
https://doi.org/10.1016/j.jalz.2008.05.1559
Autor:
Andrea Olland, Kristi Fan, Matthew R. Johnson, Yun Hu, Jim Turner, Yu Hui, Iwan Gunawan, Robichaud Albert Jean, Jonathan Bard, Michael S. Malamas, Erik Wagner, Jim Erdei, Keith D. Barnes
Publikováno v:
Journal of Medicinal Chemistry. 53:1882-1882
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2718c6d56e5592d29de47461a71c4038
https://doi.org/10.1021/jm901921x
https://doi.org/10.1021/jm901921x