Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jim E. Eyles"'
Autor:
Zachary A. Cooper, Michelle Hsueh, James Hair, Jim E. Eyles, Fabien Garcon, Simon J. Dovedi, Robert W. Wilkinson, Elena Bibikova, Laura Dallaway, Kris Sachsenmeier, Maria Letizia Giardino Torchia, Rajesh Kumar, Alwin Schuller, Gordon Moody
Publikováno v:
Cancer Research. 81:1695-1695
The catabolism of ATP into immunosuppressive adenosine contributes to the dysfunction of tumor infiltrating leukocytes (TIL). CD73 is an ectonucleotidase which catabolizes conversion of AMP to adenosine and is expressed on a range of immune cells inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3e188c7ccbede41a30296bdffb6bc4
https://doi.org/10.1158/1538-7445.am2021-1695
https://doi.org/10.1158/1538-7445.am2021-1695
Autor:
Amanda Watkins, Alwin Schuller, Fabien Garcon, Nadia Luheshi, Kristina M. Ilieva, Kelli Ryan, Stephanie Ling, Andreas Dannhorn, Gozde Kar, Tim Slidel, Jude Anderton, Brajesh P. Kaistha, Robert W. Wilkinson, Stef Mullins, Jim E. Eyles, Kris Sachsenmeier, Elena Galvani, Rajesh Kumar, Zachary A. Cooper
Publikováno v:
Cancer Research. 81:1584-1584
Intratumoral adenosine is a key immunosuppressive factor linked to poor prognosis and reduced efficacy of T cell checkpoint inhibitors. CD73 is an ectoenzyme and key node in the catabolic pathway responsible for sequential hydrolysis of extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adfeb6b6a8889ec1e7150368ad827bc
https://doi.org/10.1158/1538-7445.am2021-1584
https://doi.org/10.1158/1538-7445.am2021-1584
Autor:
Julia Li, J. Erik Johnson, Derek John Falconer, Kate West, Kathrin U. Jansen, Oscar Maldonado, Susanne Lang, Jim E. Eyles, Cheryl S. Kotash, Shawn R. Makinen, Phil White, Risini D. Weeratna, James R. Merson, Thomas P. Brown, Paul Wright, George J. Smith, Clare Lees, Susan E. Witko, Paul Cockle, Vidia Roopchand, Peter T. Loudon, Shakuntala Megati, Maninder K. Sidhu
Publikováno v:
Journal of Infectious Diseases. 208:319-329
Background. We evaluated the immunological responses of African green monkeys immunized with multiple F and G protein–based vaccines and assessed protection against the Memphis 37 strain of respiratory syncytial virus (RSV). Methods. Monkeys were i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d322dd2583760ad8a2e105c4aaeac2a
https://doi.org/10.1093/infdis/jit169
https://doi.org/10.1093/infdis/jit169
Autor:
Bruce A. Green, Richard J. Anderson, Derek John Falconer, Neil C. Sheppard, Shawn R. Makinen, Anne-Laure Goenaga, Stephen J. Gracheck, Jim E. Eyles, James R. Merson, Risini D. Weeratna, Susanne Lang, Siradanahalli Guru, Bingsheng Chang
Publikováno v:
Vaccine. 34(50)
We evaluated 52 different E. coli expressed pneumococcal proteins as immunogens in a BALB/c mouse model of S. pneumoniae lung infection. Proteins were selected based on genetic conservation across disease-causing serotypes and bioinformatic predictio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0e1d47c7a0000dc87f3533c4098fdd
https://pubmed.ncbi.nlm.nih.gov/27816374
https://pubmed.ncbi.nlm.nih.gov/27816374
Autor:
Helen C. Flick-Smith, Caroline A. Rowland, Jim E. Eyles, M. Gill Hartley, Thomas R. Laws, Petra C. F. Oyston
Publikováno v:
Microbes and Infection. 14:584-589
In this paper we evaluate the role of human γδ T cells in control of Francisella tularensis infection. Using an in vitro model of infection, a reduction in bacterial numbers was detected in the presence of human γδ T cells for both attenuated LVS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a1665fc26b2810831376210a752293
https://doi.org/10.1016/j.micinf.2012.02.001
https://doi.org/10.1016/j.micinf.2012.02.001
Autor:
Paul Wright, Peter T. Loudon, Susanne Lang, Tim J. Townend, Helen Bright, Jim E. Eyles, Michael J. McCluskie, Katrina Gore, Debbie Chappell, Daisy Hammond, Clare Christy, Paul Cockle, Dana M. Evans, Kate West, Tansi Khodai
Publikováno v:
Clinical and Vaccine Immunology. 18:1702-1709
Despite several attempts to develop an effective prophylactic vaccine for HSV-2, all have failed to show efficacy in the clinic. The most recent of these failures was the GlaxoSmithKline (GSK) subunit vaccine based on the glycoprotein gD with the adj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9691b2ab6a04fd1551cdec6f0ad04204
https://doi.org/10.1128/cvi.05071-11
https://doi.org/10.1128/cvi.05071-11
Autor:
Richard W. Titball, Petra C. F. Oyston, Margaret G. Hartley, Rachel E. Dean, Emma Waters, Jim E. Eyles, Stephen L. Michell, Joann L. Prior
Publikováno v:
Journal of Medical Microbiology. 59:1275-1284
As there is currently no licensed vaccine against Francisella tularensis, the causative agent of tularaemia, the bacterium is an agent of concern as a potential bioweapon. Although F. tularensis has a low infectious dose and high associated mortality
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194ec09e9b108ea58c82aadeda28a165
https://doi.org/10.1099/jmm.0.018911-0
https://doi.org/10.1099/jmm.0.018911-0
Autor:
Jim E. Eyles
Publikováno v:
Endocrine‚ Metabolic & Immune Disorders-Drug Targets. 7:177-186
Major advances in our understanding of how the mammalian immune system recognises pathogens have evolved from initial observations of fruit-fly developmental mutants. Through this work it has been established that vertebrates possess a specialised 'e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01144779f45da37a599892342e84cb10
https://doi.org/10.2174/187153007781662594
https://doi.org/10.2174/187153007781662594
Autor:
Helen C. Flick-Smith, Joann L. Prior, Richard W. Titball, Pierre Baldi, Siddiqua Hirst, Arlo Randall, D. Huw Davies, Douglas M. Molina, Kate F. Griffin, Philip L. Felgner, Yunxiang Mu, Margaret G. Hartley, Tim Milne, Sarah L. Newstead, Jim E. Eyles, Petra C. F. Oyston, Berkay Unal
Publikováno v:
PROTEOMICS. 7:2172-2183
Stimulation of protective immune responses against intracellular pathogens is difficult to achieve using non-replicating vaccines. BALB/c mice immunized by intramuscular injection with killed Francisella tularensis (live vaccine strain) adjuvanted wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c942cae03cbefb05181e7b3c6edc39
https://doi.org/10.1002/pmic.200600985
https://doi.org/10.1002/pmic.200600985
Autor:
Stephen J. Elvin, Satyanarayan Somavarappu, Kenneth Alan Howard, E. Diane Williamson, Easwaran Ravichandran, Jim E. Eyles, H. Oya Alpar
Publikováno v:
Vaccine. 24:4433-4439
Protection against virulent plague challenge by the parenteral and aerosol routes was afforded by a single administration of microencapsulated Caf1 and LcrV antigens from Yersinia pestis in BALB/c mice. Recombinant Caf1 and LcrV were individually enc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ecda868373f0ab6f7655479a5afec7
https://doi.org/10.1016/j.vaccine.2005.12.016
https://doi.org/10.1016/j.vaccine.2005.12.016