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Autor:
Robert P. Davis, Kelly Locke, Rab K. Prinjha, Peter D. Craggs, Gang Yao, Chun-wa Chung, Kenneth E Lind, Oxana Polyakova, Jim E Coote, Daniel J. Slade, Jim Thorpe, John Liddle, David Matthew Wilson, Benjamin D. Bax, Denisa D. Wagner, Kimberly Martinod, Ryan P. Bingham, Yu Hua Chen, Kevin L. Bicker, Claire Maller, Matthew Campbell, Gerard Joberty, Huw D. Lewis, Dirk Eberhard, Martin Rüdiger, Gerard Drewes, Paul R. Thompson, Cecil E Rise, Robert J. Sheppard, Chris Patten, Stephen John Atkinson, Michael David Barker, Pamela Thomas
Publikováno v:
Nature chemical biology
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have