Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jim Driscoll"'
Autor:
Leo Berezhkovsky, Mark Ultsch, Jan Smith, Wade S. Blair, Adam R. Johnson, Calum Macleod, Simon Charles Goodacre, Jason DeVoss, Jun Liang, Kapil Menghrajani, Jim Driscoll, Nico Ghilardi, Wenqian Yang, Steven Magnuson, Karen Williams, Anne van Abbema, Donnie Delarosa, Pawan Bir Kohli, Hieu Nguyen, Kathy Barrett, Steven Shia, Birong Zhang, Sue Sohn, Zhonghua Lin, Christine Chang, Mercedesz Balazs, Priscilla Mantik, Yingjie Lai, Charles Eigenbrot, Vickie Tsui, Amy Sambrone, Ivan Peng, Lawren C. Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
Herein we report identification of an imidazopyridine class of potent and selective TYK2 inhibitors, exemplified by prototype 6, through constraint of the rotatable amide bond connecting the pyridine and aryl rings of compound 1. Further optimization
Autor:
Sue Sohn, Nico Ghilardi, Priscilla Mantik, Christine Chang, Mercedesz Balazs, Paul Gibbons, Jan Smith, Ivan Peng, Jason DeVoss, Bing-Yan Zhu, Kathy Barrett, Wade S. Blair, Yisong Xiao, Steven Shia, Birong Zhang, Jim Driscoll, Donnie Delarosa, Young G. Shin, Jeremy Murray, Steven Magnuson, Leo Berezhkovsky, Wenqian Yang, Anne van Abbema, Charles Eigenbrot, Lawren C. Wu, Adam R. Johnson, Pawan Bir Kohli, Vickie Tsui, Mark Ultsch, Jason Halladay, Amy Sambrone, Yingjie Lai, Joseph P. Lyssikatos, Yanzhou Liu, Kapil Menghrajani, Jun Liang, Judy Young
Publikováno v:
Journal of Medicinal Chemistry. 56:4521-4536
Herein we report our lead optimization effort to identify potent, selective, and orally bioavailable TYK2 inhibitors, starting with lead molecule 3. We used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropyl
Autor:
Jim Driscoll
Publikováno v:
Canadian Journal of Political Science. 41:781-782
Autor:
Helen Stanbro, Jim Driscoll
Publikováno v:
Bulletin of the Atomic Scientists. 49:47-47
Autor:
Jim Driscoll
Publikováno v:
The Journal of Social Welfare Law. 9:280-299
(1987). Protest and public order: The public order act 1986. The Journal of Social Welfare Law: Vol. 9, No. 5, pp. 280-299.
Autor:
Jim Driscoll
Publikováno v:
The Journal of Social Welfare Law. 8:65-76
Autor:
Jim Driscoll, L. L. M. Solicitor
Publikováno v:
The Journal of Social Welfare Law. 8:32-41