Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Jim C. Norman"'
Autor:
Sergi Marco, Matthew Neilson, Madeleine Moore, Arantxa Perez-Garcia, Holly Hall, Louise Mitchell, Sergio Lilla, Giovani R. Blanco, Ann Hedley, Sara Zanivan, Jim C. Norman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Effective delivery of signals from the cell surface to the nucleus is a key to activate gene transcription. Here, the authors show how endosomes containing EphA2 are transported and captured at the nuclear surface, triggering depletion of G-actin fro
Externí odkaz:
https://doaj.org/article/5026a0dde67b478d8be77b8ddb4c8629
Autor:
Vinaya Phatak, Yannick von Grabowiecki, Justyna Janus, Leah Officer, Caron Behan, Lydia Aschauer, Lucia Pinon, Hannah Mackay, Sara Zanivan, Jim C. Norman, Michael Kelly, John Le Quesne, Patricia A. J. Muller
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in promoting metastas
Externí odkaz:
https://doaj.org/article/7870e3a860c84d64a2df479d8e0f4418
Autor:
David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts,
Externí odkaz:
https://doaj.org/article/5887f05591104f9e9068f2413b7885fd
Autor:
Emmanuel Dornier, Nicolas Rabas, Louise Mitchell, David Novo, Sandeep Dhayade, Sergi Marco, Gillian Mackay, David Sumpton, Maria Pallares, Colin Nixon, Karen Blyth, Iain R. Macpherson, Elena Rainero, Jim C. Norman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Glutamine metabolism is well known to support tumour growth. Here the authors show that cancer cells also utilize glutamine to promote invasiveness by converting it to glutamate, which upon secretion activates metabotropic glutamate receptors to stim
Externí odkaz:
https://doaj.org/article/95a420185d6b4ba7bc31aa16884f649e
Autor:
Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller, Emmanuel Dornier, Louise Mitchell, Patrick T. Caswell, Andrew D. Campbell, Anna Hogeweg, Owen J. Sansom, Jennifer P. Morton, Jim C. Norman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Ephrin receptors mediate contact inhibition, but their intracellular trafficking during this process is unknown. Here the authors show that EphA2 receptor trafficking is regulated by the Rab GTPase effector Rab-coupling protein, which associates with
Externí odkaz:
https://doaj.org/article/74f2ebe037a54017b8f114ad988e154b
Autor:
Juan R. Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J. Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R. MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G. Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V.E. van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M. Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C. Norman, Sara Zanivan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
The secretome from cancer and stromal cells contributes to the creation of a microenvironment, which in turn contributes to invasion and angiogenesis. Here, the authors compare the secretomes of immortalized normal fibroblasts and cancer-derived fibr
Externí odkaz:
https://doaj.org/article/95c1f45d24284070873d0d702ce64647
Autor:
Emmanuel Dornier, Jim C. Norman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-3 (2018)
Abstract When an invading cancer cell attempts to pass through a hole in the extracellular matrix (ECM) which is too small for its nucleus, this generates physical tension. This tension is sensed by a nucleus–centrosome connection that activates tr
Externí odkaz:
https://doaj.org/article/a6353e4678504b70b9f1e274bcf172db
Autor:
Joanna Birch, Cassie J. Clarke, Andrew D. Campbell, Kirsteen Campbell, Louise Mitchell, Dritan Liko, Gabriela Kalna, Douglas Strathdee, Owen J. Sansom, Matthew Neilson, Karen Blyth, Jim C. Norman
Publikováno v:
Biology Open, Vol 5, Iss 10, Pp 1371-1379 (2016)
The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, the level of the initiator methionine tRNA (tRNAiMet) in stromal fibroblasts has been shown to influence extracellular matrix (ECM) secretion to drive tumour growth a
Externí odkaz:
https://doaj.org/article/39dff8d34ac04872b6f6629be6e5ac1c
Autor:
Elena Rainero, Jonathan D. Howe, Patrick T. Caswell, Nigel B. Jamieson, Kurt Anderson, David R. Critchley, Laura Machesky, Jim C. Norman
Publikováno v:
Cell Reports, Vol 10, Iss 3, Pp 398-413 (2015)
Integrin trafficking is key to cell migration, but little is known about the spatiotemporal organization of integrin endocytosis. Here, we show that α5β1 integrin undergoes tensin-dependent centripetal movement from the cell periphery to populate a
Externí odkaz:
https://doaj.org/article/1a453e25f49f4eeba6d756bcb1a28d38
Autor:
Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
Publikováno v:
eLife, Vol 10 (2021)
RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine and the mechanisms of how they contribute to tumourigenesis remain
Externí odkaz:
https://doaj.org/article/d5581e9d01e64d7795bb78b98f7139a1