Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Jim C Norman"'
Autor:
Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen J Sansom, David M Bryant, Julia B Cordero
Publikováno v:
eLife, Vol 10 (2021)
RAS-like (RAL) GTPases function in Wnt signalling-dependent intestinal stem cell proliferation and regeneration. Whether RAL proteins work as canonical RAS effectors in the intestine and the mechanisms of how they contribute to tumourigenesis remain
Externí odkaz:
https://doaj.org/article/d5581e9d01e64d7795bb78b98f7139a1
Autor:
Juan Pablo Macagno, Jesica Diaz Vera, Yachuan Yu, Iain MacPherson, Emma Sandilands, Ruth Palmer, Jim C Norman, Margaret Frame, Marcos Vidal
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004262 (2014)
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downst
Externí odkaz:
https://doaj.org/article/5abc0a13ae3b4fa48e42b051edf906a3
Autor:
Elena Rainero, Cristina Cianflone, Paolo Ettore Porporato, Federica Chianale, Valeria Malacarne, Valentina Bettio, Elisa Ruffo, Michele Ferrara, Fabio Benecchia, Daniela Capello, Wolfgang Paster, Irene Locatelli, Alessandra Bertoni, Nicoletta Filigheddu, Fabiola Sinigaglia, Jim C Norman, Gianluca Baldanzi, Andrea Graziani
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e97144 (2014)
Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cy
Externí odkaz:
https://doaj.org/article/66b47552bef645f1b45c28e4c5ca2e51
Autor:
Andrew D Campbell, Samuel Lawn, Lynn C McGarry, Heidi C Welch, Bradford W Ozanne, Jim C Norman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53982 (2013)
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectop
Externí odkaz:
https://doaj.org/article/81340385daf54406a5063cf8a78c1e81
Autor:
Donatella Valdembri, Patrick T Caswell, Kurt I Anderson, Juliane P Schwarz, Ireen König, Elena Astanina, Francesca Caccavari, Jim C Norman, Martin J Humphries, Federico Bussolino, Guido Serini
Publikováno v:
PLoS Biology, Vol 7, Iss 1, p e25 (2009)
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular defects that differ from those of mice lacking either VEGF-A16
Externí odkaz:
https://doaj.org/article/4ba63edc09624beebbe0aa89b3203a1c
Autor:
Vinaya Phatak, Yannick von Grabowiecki, Justyna Janus, Leah Officer, Caron Behan, Lydia Aschauer, Lucia Pinon, Hannah Mackay, Sara Zanivan, Jim C. Norman, Michael Kelly, John Le Quesne, Patricia A. J. Muller
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract TP53 is the most frequently mutated gene in cancers. Mutations lead to loss of p53 expression or expression of a mutant protein. Mutant p53 proteins commonly lose wild-type function, but can also acquire novel functions in promoting metastas
Externí odkaz:
https://doaj.org/article/7870e3a860c84d64a2df479d8e0f4418
Autor:
Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick Caswell
Publikováno v:
Journal of Cell Science.
Endocytic recycling controls the return of internalised cargos to the plasma membrane to coordinate their positioning, availability and downstream signalling. The Rab4 and Rab11 small GTPase families regulate distinct recycling routes, broadly classi
Autor:
Mara H. Sherman, Jurre J. Kamphorst, Rosalie C. Sears, Jim C. Norman, Jennifer P. Morton, Craig Dorrell, Colin Nixon, Ronald M. Evans, Rosa F. Hwang, David Novo, Michelle Schug, Esmee Vringer, Nicholas D. Kendsersky, Jason Link, Brittany L. Allen-Petersen, Sergey Tumanov, Sohinee Bhattacharyya, Mark Berry, Jacqueline Tait-Mulder, Chet Oon, Vinay Bulusu, Francesca R. Auciello
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b073e59a30c870401a24ddf83ddbc39
https://doi.org/10.1158/2159-8290.22532899
https://doi.org/10.1158/2159-8290.22532899
Autor:
Mara H. Sherman, Jurre J. Kamphorst, Rosalie C. Sears, Jim C. Norman, Jennifer P. Morton, Craig Dorrell, Colin Nixon, Ronald M. Evans, Rosa F. Hwang, David Novo, Michelle Schug, Esmee Vringer, Nicholas D. Kendsersky, Jason Link, Brittany L. Allen-Petersen, Sergey Tumanov, Sohinee Bhattacharyya, Mark Berry, Jacqueline Tait-Mulder, Chet Oon, Vinay Bulusu, Francesca R. Auciello
Figure S1-S5 with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d112b8f8b610cdfc755fd1de6603a7d
https://doi.org/10.1158/2159-8290.22532902.v1
https://doi.org/10.1158/2159-8290.22532902.v1
Autor:
Mara H. Sherman, Jurre J. Kamphorst, Rosalie C. Sears, Jim C. Norman, Jennifer P. Morton, Craig Dorrell, Colin Nixon, Ronald M. Evans, Rosa F. Hwang, David Novo, Michelle Schug, Esmee Vringer, Nicholas D. Kendsersky, Jason Link, Brittany L. Allen-Petersen, Sergey Tumanov, Sohinee Bhattacharyya, Mark Berry, Jacqueline Tait-Mulder, Chet Oon, Vinay Bulusu, Francesca R. Auciello
Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f781a3ef8422e1dbaf631f79ca4982
https://doi.org/10.1158/2159-8290.22532896
https://doi.org/10.1158/2159-8290.22532896