Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jim Buthod"'
Autor:
Dongwoo Shin, Arun K. Ghosh, Louis E. Holland, K. Krishnan, Jim Buthod, Lisa M. Swanson, D. Eric Walters, Hanna Cho, Khaja Azhar Hussain
Publikováno v:
Il Farmaco. 56:29-32
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Autor:
Jose G. Trevino, K. Krishnan, Yumee Koo, Louis E. Holland, Wonhwa Cho, Arun K. Ghosh, D. Eric Walters, Hanna Cho, Jim Buthod
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:979-982
A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.
Autor:
John F. Kincaid, Jim Buthod, Wonhwa Cho, Clare Rudall, Arun K. Ghosh, Hanna Cho, Louis E. Holland, Yumee Koo, D. Eric Walters, Khaja Azhar Hussain, K. Krishnan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:687-690
Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
Autor:
Arun K. Ghosh, D. E. Walters, Jim Buthod, K. Krishnan, Hanna Cho, Y. Kooe, W. Cho, Jose G. Trevino, Louis E. Holland
Publikováno v:
ChemInform. 29
Autor:
Dongwoo Shin, K. Krishnan, Hanna Cho, Louis E. Holland, Lisa M. Swanson, Khaja Azhar Hussain, Jim Buthod, Arun K. Ghosh, D. Eric Walters
Publikováno v:
ChemInform. 32
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Autor:
Lisa M. Swanson, Louis E. Holland, Jim Buthod, Chunfeng Liu, Hanna Cho, Arun K. Ghosh, Khaja Azhar Hussain, D. Eric Walters
Publikováno v:
ChemInform. 33
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar
Novel cyclourethane-derived HIV protease inhibitors: a ring-closing olefin metathesis based strategy
Autor:
D. Eric Walters, Lisa M. Swanson, Chunfeng Liu, Hanna Cho, Khaja Azhar Hussain, Jim Buthod, Arun K. Ghosh, Louis E. Holland
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(15)
A series of novel macrocyclic urethanes incorporating a (R)-hydroxyethylamine isostere was designed and synthesized. Ring size and substituent efffects have been investigated. Cyclourethanes containing 14- to 16-membered rings exhibited low nanomolar