CALR-mutated cells are vulnerable to combined inhibition of the proteasome and the endoplasmic reticulum stress response.

Autor: Jutzi JS; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Marneth AE; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Jiménez-Santos MJ; Bioinformatics Unit, Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Hem J; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Guerra-Moreno A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Rolles B; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Bhatt S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pharmacy, National University of Singapore, Singapore, Singapore., Myers SA; Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology, La Jolla, CA, 92037, USA., Carr SA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hong Y; Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, 3083, Australia., Pozdnyakova O; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., van Galen P; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Al-Shahrour F; Bioinformatics Unit, Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Nam AS; Weill Cornell Medicine, New York City, N.Y., USA., Mullally A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ann_mullally@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ann_mullally@dfci.harvard.edu.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. ann_mullally@dfci.harvard.edu.

Publikováno v: Leukemia [Leukemia] 2023 Feb; Vol. 37 (2), pp. 359-369. Date of Electronic Publication: 2022 Dec 06.

Whole-genome CRISPR screening identifies N-glycosylation as a genetic and therapeutic vulnerability in CALR-mutant MPNs.

Autor: Jutzi JS; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Marneth AE; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Ciboddo M; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; The Ben May Department for Cancer Research, University of Chicago, Chicago, IL., Guerra-Moreno A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Jiménez-Santos MJ; Bioinformatics Unit, Structural Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Kosmidou A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Dressman JW; Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC., Liang H; Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC., Hamel R; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; RWTH Aachen University, Aachen, Germany., Lozano P; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA., Rumi E; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Hematology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy., Doench JG; Broad Institute, Cambridge, MA., Gotlib J; Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Krishnan A; Department of Pathology, Stanford Cancer Institute, Stanford University School of Medicine, Palo Alto, CA; and., Elf S; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; The Ben May Department for Cancer Research, University of Chicago, Chicago, IL., Al-Shahrour F; Bioinformatics Unit, Structural Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Mullally A; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.; Broad Institute, Cambridge, MA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

Publikováno v: Blood [Blood] 2022 Sep 15; Vol. 140 (11), pp. 1291-1304.

Beyondcell: targeting cancer therapeutic heterogeneity in single-cell RNA-seq data.

Autor: Fustero-Torre C; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., Jiménez-Santos MJ; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., García-Martín S; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., Carretero-Puche C; Laboratorio de Oncología Clínico-Traslacional, Unidad de Investigación en tumores Digestivos, Instituto de Investigación I+12, Hospital 12 de Octubre, Av. de Córdoba, 28041, Madrid, Spain.; Lung-H120 Group, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029, Madrid, Spain., García-Jimeno L; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., Ivanchuk V; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., Di Domenico T; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., Gómez-López G; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain., Al-Shahrour F; Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO), Calle Melchor Fernandez Almagro, 3, 28029 , Madrid, Spain. falshahrour@cnio.es.

Publikováno v: Genome medicine [Genome Med] 2021 Dec 16; Vol. 13 (1), pp. 187. Date of Electronic Publication: 2021 Dec 16.

Influence of mutation bias and hydrophobicity on the substitution rates and sequence entropies of protein evolution.

Autor: Jiménez-Santos MJ; Bioinformatics Unit, Center for Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain., Arenas M; Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain., Bastolla U; Bioinformatics Unit, Center for Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain.

Publikováno v: PeerJ [PeerJ] 2018 Oct 05; Vol. 6, pp. e5549. Date of Electronic Publication: 2018 Oct 05 (Print Publication: 2018).