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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.

Autor: de Vries LE; Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Jansen PAM; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Barcelo C; Medicines for Malaria Venture, Geneva, Switzerland., Munro J; Department of Chemistry and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA., Verhoef JMJ; Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Rubiano K; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA., Striepen J; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA., Abla N; Medicines for Malaria Venture, Geneva, Switzerland., Berning L; TropIQ Health Sciences, Nijmegen, The Netherlands., Bolscher JM; TropIQ Health Sciences, Nijmegen, The Netherlands., Demarta-Gatsi C; Medicines for Malaria Venture, Geneva, Switzerland., Henderson RWM; TropIQ Health Sciences, Nijmegen, The Netherlands., Huijs T; TropIQ Health Sciences, Nijmegen, The Netherlands., Koolen KMJ; TropIQ Health Sciences, Nijmegen, The Netherlands., Tumwebaze PK; Infectious Diseases Research Collaboration, Kampala, Uganda., Yeo T; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA., Aguiar ACC; Sao Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil, São Carlos, SP, Brazil., Angulo-Barturen I; The Art of Discovery, Derio, Spain., Churchyard A; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom., Baum J; Department of Life Sciences, Imperial College London, South Kensington, London, United Kingdom., Fernández BC; Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Fuchs A; Medicines for Malaria Venture, Geneva, Switzerland., Gamo FJ; Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Guido RVC; Sao Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo, Brazil, São Carlos, SP, Brazil., Jiménez-Diaz MB; The Art of Discovery, Derio, Spain., Pereira DB; Research Center for Tropical Medicine of Rondonia, Porto Velho, Brazil., Rochford R; Department of Immunology and Microbiology, University of Colorado Anschutz School of Medicine, Aurora, CO, USA., Roesch C; Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.; Malaria Translational Research Unit, Institut Pasteur, Paris & Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Sanz LM; Global Health, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Trevitt G; Sygnature Discovery, Nottingham, United Kingdom., Witkowski B; Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.; Malaria Translational Research Unit, Institut Pasteur, Paris & Institut Pasteur du Cambodge, Phnom Penh, Cambodia., Wittlin S; Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, CA, USA., Rosenthal PJ; Department of Medicine, University of California, San Francisco, CA, USA., Sauerwein RW; Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.; TropIQ Health Sciences, Nijmegen, The Netherlands., Schalkwijk J; Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands., Hermkens PHH; Hermkens Pharma Consultancy, Oss, The Netherlands., Bonnert RV; Medicines for Malaria Venture, Geneva, Switzerland., Campo B; Medicines for Malaria Venture, Geneva, Switzerland., Fidock DA; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Llinás M; Department of Chemistry and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, USA.; Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, PA, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Kooij TWA; Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. taco.kooij@radboudumc.nl., Dechering KJ; TropIQ Health Sciences, Nijmegen, The Netherlands. k.dechering@tropiq.nl.

Publikováno v: Nature communications [Nat Commun] 2022 Apr 20; Vol. 13 (1), pp. 2158. Date of Electronic Publication: 2022 Apr 20.