Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.

Autor: Rondeau V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Berman JM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Ling T; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., O'Brien C; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Culp-Hill R; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 USA., Reisz JA; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 USA., Wunderlich M; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Chueh Y; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Jiménez-Camacho KE; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Sexton C; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Carter KM; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., Stillwell C; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA., St-Germain J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Yendi D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Gupta A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Shi M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Bourdine A; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Paralkar VR; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 USA., Jahangiri S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Hope KJ; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Tikhonova AN; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Arruda A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada., Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada., D'Alessandro A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045 USA., Jones CL; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4 Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada.; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229 USA.; Advanced Leukemia Therapies and Research Center, Cincinnati Children's Hospital, Cincinnati, OH 45229 USA.; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229 USA.; University of Cincinnati Cancer Center, Cincinnati, OH 45229 USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Sep 25; Vol. 16 (766), pp. eadn1285. Date of Electronic Publication: 2024 Sep 25.

ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19.

Autor: Lartey NL; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Valle-Reyes S; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Vargas-Robles H; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Jiménez-Camacho KE; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Guerrero-Fonseca IM; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Castellanos-Martínez R; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Montoya-García A; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., García-Cordero J; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Cedillo-Barrón L; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico., Nava P; Department of Physiology, Biophysics and Neurosciences, CINVESTAV-IPN, Mexico City, Mexico., Filisola-Villaseñor JG; Department of Biochemistry, CINVESTAV-IPN, Mexico City, Mexico., Roa-Velázquez D; Department of Biochemistry, CINVESTAV-IPN, Mexico City, Mexico., Zavala-Vargas DI; Department of Biochemistry, CINVESTAV-IPN, Mexico City, Mexico., Morales-Ríos E; Department of Biochemistry, CINVESTAV-IPN, Mexico City, Mexico., Salinas-Lara C; Instituto Nacional de Neurología, Mexico City, Mexico., Vadillo E; Oncology Research Unit, Hospital de Oncología, Centro Médico Nacional Siglo XXI, Mexico City, Mexico., Schnoor M; Department of Molecular Biomedicine, CINVESTAV-IPN, Mexico City, Mexico.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2022 Jun; Vol. 111 (6), pp. 1147-1158. Date of Electronic Publication: 2021 Nov 26.