Zobrazeno 1 - 10
of 723
pro vyhledávání: '"Jiménez, José L"'
Autor:
Xu, Mingyu, Jimenez, Jose L. Gonzalez, Jose, Greeshma C., Boonkird, Artittaya, Xing, Chengkun, Harrod, Chelsea, Li, Xinle, Zhou, Haidong, Gaiser, Alyssa, Ke, Xianglin, Bi, Wenli, Li, Mingda, Xie, Weiwei
The investigation of crystallographic, electronic, and magnetic characteristics, especially the mixed valences of Eu$^{2+}$ and Eu$^{3+}$ under pressure of a novel europium-based bismuth selenide compound, Eu$_4$Bi$_6$Se$_{13}$, presented. This new c
Externí odkaz:
http://arxiv.org/abs/2407.00163
Autor:
deSouza, Priyanka N., Anenberg, Susan, Fann, Neal, McKenzie, Lisa M., Chan, Elizabeth, Roy, Ananya, Jimenez, Jose L., Raich, William, Roman, Henry, Kinney, Patrick L.
We evaluated the sensitivity of estimated PM2.5 and NO2 health impacts to varying key input parameters and assumptions including: 1) the spatial scale at which impacts are estimated, 2) using either a single concentration-response function (CRF) or u
Externí odkaz:
http://arxiv.org/abs/2309.13703
What can be considered an appropriate statistical method for the primary analysis of a randomized clinical trial (RCT) with a time-to-event endpoint when we anticipate non-proportional hazards owing to a delayed effect? This question has been the sub
Externí odkaz:
http://arxiv.org/abs/2304.08087
Autor:
Jiménez, José L., Tighiouart, Mourad
In this article, we propose a phase I-II design in two stages for the combination of molecularly targeted therapies. The design is motivated by a published case study that combines a MEK and a PIK3CA inhibitors; a setting in which higher dose levels
Externí odkaz:
http://arxiv.org/abs/2210.08894
In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there is no added value in including an interaction term to model synergism
Externí odkaz:
http://arxiv.org/abs/2208.05726
Autor:
Magirr, Dominic, Jiménez, José L.
Delayed separation of survival curves is a common occurrence in confirmatory studies in immuno-oncology. Many novel statistical methods that aim to efficiently capture potential long-term survival improvements have been proposed in recent years. Howe
Externí odkaz:
http://arxiv.org/abs/2201.10445
Autor:
Jiménez, José L., Tighiouart, Mourad
Publikováno v:
Journal of the Royal Statistical Society: Series C (Applied Statistics), 71(5), 1996-2013
Phase I-II cancer clinical trial designs are intended to accelerate drug development. In cases where efficacy cannot be ascertained in a short period of time, it is common to divide the study in two stages: i) a first stage in which dose is escalated
Externí odkaz:
http://arxiv.org/abs/2109.14231
Publikováno v:
In Journal of Computational Science June 2024 78
Autor:
Jiménez, José L., Zheng, Haiyan
Combination of several anti-cancer treatments has typically been presumed to have enhanced drug activity. Motivated by a real clinical trial, this paper considers phase I-II dose finding designs for dual-agent combinations, where one main objective i
Externí odkaz:
http://arxiv.org/abs/2106.08277
Autor:
Pellicer-Valero, Oscar J., Jiménez, José L. Marenco, Gonzalez-Perez, Victor, Ramón-Borja, Juan Luis Casanova, García, Isabel Martín, Benito, María Barrios, Gómez, Paula Pelechano, Rubio-Briones, José, Rupérez, María José, Martín-Guerrero, José D.
The emergence of multi-parametric magnetic resonance imaging (mpMRI) has had a profound impact on the diagnosis of prostate cancers (PCa), which is the most prevalent malignancy in males in the western world, enabling a better selection of patients f
Externí odkaz:
http://arxiv.org/abs/2103.12650