Zobrazeno 1 - 10 of 87 pro vyhledávání: '"Jim, Dimitroulakos"'
1
Akademický článek
Does metformin usage improve survival in head and neck squamous cell carcinoma? A population-based study
Autor: Alexandra E. Quimby, Nicole L. Lebo, Rebecca Griffiths, Stephen Hall, Jim Dimitroulakos, Stephanie Johnson-Obaseki
Publikováno v: Journal of Otolaryngology - Head and Neck Surgery, Vol 47, Iss 1, Pp 1-9 (2018)
Abstract Background We sought to expand upon preliminary data suggesting that metformin confers a survival benefit to patients with head and neck squamous cell carcinoma (HNSCC). Methods A large-scale retrospective cohort study of all patients in Ont
Externí odkaz: https://doaj.org/article/ec9dab7eaefb4db2b8e43ba2958734f7
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2
Akademický článek
Activating Transcription Factor 3 as a Novel Regulator of Chemotherapy Response in Breast Cancer
Autor: Mohamed S. Hasim, Carolyn Nessim, Patrick J. Villeneuve, Barbara C. Vanderhyden, Jim Dimitroulakos
Publikováno v: Translational Oncology, Vol 11, Iss 4, Pp 988-998 (2018)
Anthracyclines, such as doxorubicin, are used as first-line chemotherapeutics, usually in combination therapies, for the treatment of advanced breast cancer. While these drugs have been successful therapeutic options, their use is limited due to seri
Externí odkaz: https://doaj.org/article/dddf536142274f1496f3345080bca3a7
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3
Akademický článek
Dual inhibition of Wnt and Yes‐associated protein signaling retards the growth of triple‐negative breast cancer in both mesenchymal and epithelial states
Autor: Andrew Sulaiman, Sarah McGarry, Li Li, Deyong Jia, Sarah Ooi, Christina Addison, Jim Dimitroulakos, Angel Arnaout, Carolyn Nessim, Zemin Yao, Guang Ji, Haiyan Song, Suresh Gadde, Xuguang Li, Lisheng Wang
Publikováno v: Molecular Oncology, Vol 12, Iss 4, Pp 423-440 (2018)
Triple‐negative breast cancer (TNBC), the most refractory subtype of breast cancer to current treatments, accounts disproportionately for the majority of breast cancer‐related deaths. This is largely due to cancer plasticity and the development o
Externí odkaz: https://doaj.org/article/f9bb18fbca3141349a23f12b1118c026
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4
Akademický článek
Induction of Activating Transcription Factor 3 Is Associated with Cisplatin Responsiveness in Non–Small Cell Lung Carcinoma Cells
Autor: Jair Bar, Mohamed S. Hasim, Tabassom Baghai, Nima Niknejad, Theodore J. Perkins, David J. Stewart, Harmanjatinder S. Sekhon, Patrick J. Villeneuve, Jim Dimitroulakos
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 9, Pp 525-535 (2016)
Non–small cell lung carcinoma (NSCLC) is the most common cause of cancer deaths, with platin-based combination chemotherapy the most efficacious therapies. Gains in overall survival are modest, highlighting the need for novel therapeutic approaches
Externí odkaz: https://doaj.org/article/62c40392758141428b661fe1a30fdc89
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5
Data from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Autor: Jim Dimitroulakos, Johanne I. Weberpals, Harmanjatinder S. Sekhon, Patrick J. Villeneuve, Martin Corsten, Stephanie Johnson-Obaseki, Khalil Dayekh
Targeting the EGFR, with inhibitors such as erlotinib, represents a promising therapeutic option in advanced head and neck squamous cell carcinomas (HNSCC). However, they lack significant efficacy as single agents. Recently, we identified the ability
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3693c1e574a74f33e08a932b1538b4ab
https://doi.org/10.1158/1535-7163.c.6536844.v1
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6
Data from Customized Viral Immunotherapy for HPV-Associated Cancer
Autor: Brian D. Lichty, Yonghong Wan, Jim Dimitroulakos, Jean-Simon Diallo, Patrick J. Villeneuve, Stephanie Johnson-Obaseki, Lan Chen, Andrew Nguyen, Anna Dvorkin-Gheva, Jake K. Nikota, David F. Stojdl, Charles Lefebvre, Fuan Wang, Jonathan Pol, Kyle B. Stephenson, Matthew J. Atherton
The viral-transforming proteins E6 and E7 make human papillomavirus–positive (HPV+) malignancies an attractive target for cancer immunotherapy. However, therapeutic vaccination exerts limited efficacy in the setting of advanced disease. We designed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::004a25a427aaa5e64e2a182de6d996b3
https://doi.org/10.1158/2326-6066.c.6548717.v1
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