Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Jilly F. Evans"'
Publikováno v:
European Respiratory Review, Vol 32, Iss 169 (2023)
Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 activation enhances a plethora of a
Externí odkaz:
https://doaj.org/article/b4061b3adcca44b1a7374c0f3bb2694c
Autor:
Kseniya Obraztsova, Maria C. Basil, Ryan Rue, Aravind Sivakumar, Susan M. Lin, Alexander R. Mukhitov, Andrei I. Gritsiuta, Jilly F. Evans, Meghan Kopp, Jeremy Katzen, Annette Robichaud, Elena N. Atochina-Vasserman, Shanru Li, Justine Carl, Apoorva Babu, Michael P. Morley, Edward Cantu, Michael F. Beers, David B. Frank, Edward E. Morrisey, Vera P. Krymskaya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-oper
Externí odkaz:
https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e
Autor:
Malvina Hoxha, Calogero C. Tedesco, Silvana Quaglin, Visar Malaj, Linda Pustina, Valerie Capra, Jilly F. Evans, Angelo Sala, G. Enrico Rovati
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Cysteinyl leukotrienes are proinflammatory mediators with a clinically established role in asthma and a human genetic and preclinical role in cardiovascular pathology. Given that cardiovascular disease has a critical inflammatory component, the aim o
Externí odkaz:
https://doaj.org/article/d5bfab8ff59649f7890c5f2ef03e7fc7
Autor:
Jilly F. Evans, Ryan W. Rue, Alexander R. Mukhitov, Kseniya Obraztsova, Carly J. Smith, Vera P. Krymskaya
Publikováno v:
Biomolecules, Vol 10, Iss 1, p 28 (2019)
Lymphangioleiomyomatosis (LAM) is a rare metastatic cystic lung disease due to a mutation in a TSC tumor suppressor, resulting in hyperactive mTOR growth pathways. Sirolimus (rapamycin), an allosteric mTORC1 inhibitor, is a therapeutic option for wom
Externí odkaz:
https://doaj.org/article/b40ff0dd99e24b9e81de04578169971c
Autor:
Takehiko Yokomizo, Mohib Uddin, Takao Shimizu, Charles N. Serhan, G. Enrico Rovati, Joshua Rokach, William Powell, Motonao Nakamura, Douglas W. P. Hay, Jilly F. Evans, Jeffrey Drazen, Gordon Dent, Sven-Erik Dahlén, Nan Chiang, Charles Brink, Magnus Bäck
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The leukotriene receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Leukotriene Receptors [35, 38]) are activated by the endogenous ligands leukotrienes (LT), synthesized from lipoxygenase metabolism of arachidonic acid. The human BLT1
Autor:
Blanca E Himes, Kseniya Obraztsova, Lurong Lian, Maya Shumyatcher, Ryan Rue, Elena N Atochina-Vasserman, Stella K Hur, Marisa S Bartolomei, Jilly F Evans, Vera P Krymskaya
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197105 (2018)
Lymphangioleiomyomatosis (LAM) is a rare, almost exclusively female lung disease linked to inactivating mutations in tuberous sclerosis complex 2 (TSC2), a tumor suppressor gene that controls cell metabolic state and growth via regulation of the mech
Externí odkaz:
https://doaj.org/article/dc3af48d07f2469fa4b013c8f3428a2a
Autor:
Maria C. Basil, Susan M. Lin, Jilly F. Evans, Edward E. Morrisey, Justine Carl, Aravind Sivakumar, Ryan Rue, Shanru Li, Michael Morley, Andrei I. Gritsiuta, Kseniya Obraztsova, Jeremy Katzen, David B. Frank, Edward Cantu, Annette Robichaud, Vera P. Krymskaya, Apoorva Babu, Alexander R. Mukhitov, Elena N. Atochina-Vasserman, Michael F. Beers, Meghan Kopp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin o
Autor:
Takao Shimizu, Jeffrey M. Drazen, Marc Parmentier, Nan Chiang, Sven-Erik Dahlén, Charles N. Serhan, Mark T. Quinn, Claes Dahlgren, G. Enrico Rovati, François Boulay, Takehiko Yokomizo, Jilly F. Evans, Magnus Bäck, Craig Gerard, Ji Ming Wang, Philip M. Murphy, Richard D. Ye
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The formylpeptide receptors (nomenclature agreed by the NC-IUPHAR Subcommittee on the formylpeptide receptor family [196]) respond to exogenous ligands such as the bacterial product fMet-Leu-Phe (fMLP) and endogenous ligands such as lipoxin A4 (LXA4)
Autor:
Vera P. Krymskaya, Ryan Rue, Kseniya Obraztsova, Jilly F. Evans, Carly J. Smith, Alexander R. Mukhitov
Publikováno v:
Biomolecules
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 28 (2019)
Volume 10
Issue 1
Biomolecules, Vol 10, Iss 1, p 28 (2019)
Lymphangioleiomyomatosis (LAM) is a rare metastatic cystic lung disease due to a mutation in a TSC tumor suppressor, resulting in hyperactive mTOR growth pathways. Sirolimus (rapamycin), an allosteric mTORC1 inhibitor, is a therapeutic option for wom
Autor:
Andiliy G. Lai, Katherine Nguyen, Gretchen Bain, Lance Goulet, Imelda Calderon, Fei Huang, Deidre A. MacKenna, Kristen E. Shannon, Janice Darlington, Patricia Prodanovich, John H. Hutchinson, David Lonergan, Angelina M. Santini, Gina L. Ma, Jilly F. Evans, Taylor Lasof, Martin W. Rowbottom, Christopher D. King
Publikováno v:
Journal of Medicinal Chemistry. 60:4403-4423
LOXL2 catalyzes the oxidative deamination of ε-amines of lysine and hydroxylysine residues within collagen and elastin, generating reactive aldehydes (allysine). Condensation with other allysines or lysines drives the formation of inter- and intramo