Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial

Autor: James H. McMahon, Jillian S.Y. Lau, Anna Coldham, Janine Roney, Michelle Hagenauer, Sally Price, Mellissa Bryant, Jill Garlick, Anne Paterson, Sue J. Lee, Jess O'Bryan, Anna Hearps, Gilda Tachedjian, Henry Pinskier, Cameron Phillips, Stuart Garrow, Nathan Pinskier, Robert Melvin, Luke Blakeway, Jessica A. Wisniewski, Sally Byers, Gnei Z. Badoordeen, Stephanie Pereira, Katherine Pragastis, Jason A. Trubiano, Kyra Y.L. Chua, Marion Kainer, James S. Molton, Bradley J. Gardiner, Anna B. Pierce, Allen Cheng, Benjamin A. Rogers, Anton Y. Peleg

Publikováno v: EClinicalMedicine, Vol 54, Iss , Pp 101703- (2022)

Summary: Background: Well tolerated antivirals administered early in the course of COVID-19 infection when the viremia is highest could prevent progression to severe disease. Favipiravir inhibits SARS-CoV-2 viral replication in vitro with evidence of

Externí odkaz: https://doaj.org/article/21ec5c21efe3489bb10bb9f88cc2c246

Time for revolution? Enhancing meaningful involvement of people living with HIV and affected communities in HIV cure-focused science

Autor: Jillian S.Y. Lau, Miranda Z. Smith, Brent Allan, Karine Dubé, A. Toni Young, Jennifer Power

Publikováno v: Journal of Virus Eradication, Vol 6, Iss 4, Pp 100018- (2020)

Introduction: Involving affected communities and people living with HIV (PLHIV) in HIV cure-focused clinical trials has ethical and practical benefits. However, there can be barriers to meaningful involvement of ‘lay people’ in scientific researc

Externí odkaz: https://doaj.org/article/ef7b7e06e1534299ae21bda3cb104913

Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency

Autor: Thomas A. Rasmussen, Jennifer M. Zerbato, Ajantha Rhodes, Carolin Tumpach, Ashanti Dantanarayana, James H. McMahon, Jillian S.Y. Lau, J. Judy Chang, Celine Gubser, Wendy Brown, Rebecca Hoh, Melissa Krone, Rachel Pascoe, Chris Y. Chiu, Michael Bramhall, Hyun Jae Lee, Ashraful Haque, Rèmi Fromentin, Nicolas Chomont, Jeffrey Milush, Renee M. Van der Sluis, Sarah Palmer, Steven G. Deeks, Paul U. Cameron, Vanessa Evans, Sharon R. Lewin

Publikováno v: Rasmussen, T A, Zerbato, J M, Rhodes, A, Tumpach, C, Dantanarayana, A, McMahon, J H, Lau, J S Y, Chang, J J, Gubser, C, Brown, W, Hoh, R, Krone, M, Pascoe, R, Chiu, C Y, Bramhall, M, Lee, H J, Haque, A, Fromentin, R, Chomont, N, Milush, J, Van der Sluis, R M, Palmer, S, Deeks, S G, Cameron, P U, Evans, V & Lewin, S R 2022, ' Memory CD4 + T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency ', Cell Reports Medicine, vol. 3, no. 10, 100766 . https://doi.org/10.1016/j.xcrm.2022.100766
Rasmussen, T A, Zerbato, J M, Rhodes, A, Tumpach, C, Dantanarayana, A, McMahon, J H, Lau, J S Y, Chang, J J, Gubser, C, Brown, W, Hoh, R, Krone, M, Pascoe, R, Chiu, C Y, Bramhall, M, Lee, H J, Haque, A, Fromentin, R, Chomont, N, Milush, J, Van der Sluis, R M, Palmer, S, Deeks, S G, Cameron, P U, Evans, V & Lewin, S R 2022, ' Memory CD4 + T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency. ', Cell Reports Medicine, pp. 100766 . https://doi.org/10.1016/j.xcrm.2022.100766

Programmed cell death 1 (PD1) and cytotoxic T lymphocyte-associated protein 4 (CTLA4) suppress CD4 + T cell activation and may promote latent HIV infection. By performing leukapheresis (n = 21) and lymph node biopsies (n = 8) in people with HIV on an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eac3cf1d47dbee21076020c6ebd2c8
https://pure.au.dk/portal/da/publications/memory-cd4-tcells-that-coexpress-pd1-and-ctla4-have-reduced-response-to-activating-stimuli-facilitating-hiv-latency(d7670f1d-7904-4614-92cb-acb34e8ac600).html

The Impact of the COVID-19 Pandemic on People Living with HIV in Victoria, Australia

Autor: Jillian S.Y. Lau, Adam Ehm, James H McMahon, Ian Woolley, Jessica O'Bryan, Jennifer F Hoy, Mihiri P. Weerasuria, Christy Ko

Publikováno v: AIDS Research and Human Retroviruses

As of January 12, 2021, Australia has reported 28,634 COVID-19 cases. Most (20,411) cases are from the state of Victoria. In response to rising infections and community transmission in July 2020, on August 2nd, several restrictions were imposed for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd44da62cf0181de0c72e5ea4c70813

Acceptability, motivation and the prospect of cure for people living with HIV and their healthcare providers in HIV cure-focused treatment interruption studies

Autor: Brent Allan, Miranda Zoe Denham Smith, James H McMahon, Jennifer Power, Cipriano Martinez, Jillian S.Y. Lau, Sharon R Lewin

Publikováno v: AIDS Research and Therapy
AIDS Research and Therapy, Vol 17, Iss 1, Pp 1-6 (2020)

Background Analytical treatment interruptions (ATI) are commonly used clinical endpoints to assess interventions aimed at curing HIV or achieving antiretroviral therapy (ART)-free HIV remission. Understanding the acceptability of ATI amongst people l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38f3039acbb034d9e9859cefa1fd715
http://europepmc.org/articles/PMC7653743