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pro vyhledávání: '"Jillian S. Losh"'
Autor:
Taylor Craig, Sara W. Leung, Graeme L. Conn, Anita H. Corbett, Sergine Brutus, Jillian C Vaught, Brittany Avin, Milo B. Fasken, Jillian S. Losh, Katherine Mills-Lujan, Ambro van Hoof, Jennifer Potter-Birriel
Publikováno v:
Genetics. 205:221-237
Pontocerebellar hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration, leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome subunit gen
Autor:
Alejandra Klauer King, Sean J. Johnson, Lacy L. Taylor, John Loomis, Jillian S. Losh, Ambro van Hoof, Jason A. Rosenzweig, Jeremy Bakelar
Publikováno v:
Nucleic Acids Research
The RNA exosome is one of the main 3′ to 5′ exoribonucleases in eukaryotic cells. Although it is responsible for degradation or processing of a wide variety of substrate RNAs, it is very specific and distinguishes between substrate and non-substr
Autor:
Jillian S. Losh, Ambro van Hoof
Publikováno v:
Cell. (5):940-941
The RNA exosome degrades many different RNAs. Thoms et al. now fill an important gap in our understanding of how the exosome recognizes distinct subsets of target RNAs.