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An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling
Autor:
Jillian M. Langer, Ayiti C. Maharaj-Best, Robert J. Fleming, Robert A. Obar, Gina V. Filloramo, Anindya Sen, Spyros Artavanis-Tsakonas, Kazuya Hori
Publikováno v:
Development. 140:2039-2049
Cell-to-cell communication via the Notch pathway is mediated between the membrane-bound Notch receptor and either of its canonical membrane-bound ligands Delta or Serrate. Notch ligands mediate receptor transactivation between cells and also mediate