Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jillian M Silva"'
Autor:
Taryn E Gillies, Michael Pargett, Jillian M Silva, Carolyn K Teragawa, Frank McCormick, John G Albeck
Publikováno v:
Molecular Systems Biology, Vol 16, Iss 10, Pp 1-19 (2020)
Abstract Activating mutations in RAS are present in ~ 30% of human tumors, and the resulting aberrations in ERK/MAPK signaling play a central role in oncogenesis. However, the form of these signaling changes is uncertain, with activating RAS mutants
Externí odkaz:
https://doaj.org/article/804bdc66e1774d43b932492177689289
Autor:
Martin McMahon, Joe W. Gray, Wayne A. Phillips, Paul T. Spellman, David Dankort, Byron Hann, Brian A. Rabinovich, Roch-Philippe Charles, Laura M. Heiser, James E. Korkola, Shenda Gu, Jillian M. Silva, Christy L. Trejo, Eric A. Collisson
PDF file - 194K, RAF and MEK co inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184315b9afc1313b6735a810d27fc718
https://doi.org/10.1158/2159-8290.22528382
https://doi.org/10.1158/2159-8290.22528382
PDF file - 68K, Supplementary Table S1. Panel of human BRAF mutated melanoma-derived cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762f7c883e9b895a189982e51393c235
https://doi.org/10.1158/1541-7786.22510980.v1
https://doi.org/10.1158/1541-7786.22510980.v1
PDF file - 92K, Supplementary Fig. S4. Quantification of Crystal Violet staining experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79707b171f13582c86723dba126f4e93
https://doi.org/10.1158/1541-7786.22510986
https://doi.org/10.1158/1541-7786.22510986
PDF file - 64K, Supplementary Fig. S2. Protein quantification of p70S6K, rpS6, and 4E-BP1 phosphorylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ec755b7b72a605e301f1be6cb0cb9f
https://doi.org/10.1158/1541-7786.22510992.v1
https://doi.org/10.1158/1541-7786.22510992.v1
PDF file - 55K, Supplementary Table S3. Antibodies used for immunoblot analyses in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f550a08899d752083d6df8b927a037e
https://doi.org/10.1158/1541-7786.22510974.v1
https://doi.org/10.1158/1541-7786.22510974.v1
PDF file - 74K, Supplementary Fig. S1. A schematic diagram of the ERK1/2 MAP kinase and PI3'-kinase-AKT signaling pathways and the targeted pharmacological inhibitors used in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f90ad9f043698b07a9c555ab79097b
https://doi.org/10.1158/1541-7786.22510995.v1
https://doi.org/10.1158/1541-7786.22510995.v1
Autor:
Martin McMahon, Joe W. Gray, Wayne A. Phillips, Paul T. Spellman, David Dankort, Byron Hann, Brian A. Rabinovich, Roch-Philippe Charles, Laura M. Heiser, James E. Korkola, Shenda Gu, Jillian M. Silva, Christy L. Trejo, Eric A. Collisson
PDF file - 379K, Dose response curves of human PDA cell lines treated with either MEK inhibitor GSK1120212, AKT inhibitor GSK690693, or both together
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b05a82ac56d15e8f687e3ea11d83693
https://doi.org/10.1158/2159-8290.22528376
https://doi.org/10.1158/2159-8290.22528376
PDF file - 117K, Supplementary Fig. S3. Effects of rapamycin on melanoma cell signaling and proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51568ab570f7b1ed55f53ac7d99bc6af
https://doi.org/10.1158/1541-7786.22510989
https://doi.org/10.1158/1541-7786.22510989
PDF file - 62K, Supplementary Table S2. Pharmacological agents targeted to the ERK1/2 MAP kinase or PI3'- kinase-AKT pathways.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fad741f6cb946d43684a571474b798
https://doi.org/10.1158/1541-7786.22510977.v1
https://doi.org/10.1158/1541-7786.22510977.v1