Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jillian M Hagel"'
Autor:
Ryan A Groves, Jillian M Hagel, Ye Zhang, Korey Kilpatrick, Asaf Levy, Frédéric Marsolais, Efraim Lewinsohn, Christoph W Sensen, Peter J Facchini
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119701 (2015)
Amphetamine analogues are produced by plants in the genus Ephedra and by khat (Catha edulis), and include the widely used decongestants and appetite suppressants (1S,2S)-pseudoephedrine and (1R,2S)-ephedrine. The production of these metabolites, whic
Externí odkaz:
https://doaj.org/article/cc72bf46714b4fa3bd3bd50ce8d1d1bb
Autor:
Qiushi Li, Sukanya Ramasamy, Pooja Singh, Jillian M. Hagel, Sonja M. Dunemann, Xue Chen, Rongji Chen, Lisa Yu, Joseph E. Tucker, Peter J. Facchini, Sam Yeaman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The opium poppy has been a source of painkilling drugs synthesized by the benzylisoquinoline alkaloid pathway. Here, the authors report an improved genome assembly and reveal gene clustering and copy number variation in alkaloid metabolic pathways.
Externí odkaz:
https://doaj.org/article/e91dc3f830b242d7bc6f05c17604aa7b
Publikováno v:
ACS Chemical Biology. 18:419-430
Autor:
Sheetal A. Raithatha, Jillian M. Hagel, Kaveh Matinkhoo, Lisa Yu, David Press, Sarah G. Cook, Govinda Sharma, Dhananjaya D., Glynnis Jensen, Jessica B. Lee, Charlie Cai, Jonathan Gallant, Jaideep S. Bains, Joseph E. Tucker, Peter J. Facchini
The psychedelic compound psilocybin has shown therapeutic benefit in the treatment of numerous psychiatric diseases. A recent randomized clinical trial conducted at Johns Hopkins Bayview Medical Center demonstrated the efficacy of psilocybin-assisted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f670e03ad5c8521c0f565abb4bfbbfa9
https://doi.org/10.1101/2023.05.16.540994
https://doi.org/10.1101/2023.05.16.540994
Autor:
Natali Ozber, Samuel C. Carr, Jeremy S. Morris, Siyu Liang, Jacinta L. Watkins, Kristian M. Caldo, Jillian M. Hagel, Kenneth K. S. Ng, Peter J. Facchini
Publikováno v:
Nature Communications. 13
Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers, which compose an internal secretory system associated with phloem throughout th
Autor:
Qiushi Li, Sukanya Ramasamy, Pooja Singh, Jillian M. Hagel, Sonja M. Dunemann, Xue Chen, Rongji Chen, Lisa Yu, Joseph E. Tucker, Peter J. Facchini, Sam Yeaman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/6ae5b4573d5441dbbedaf32f39f4198d
Autor:
Lisa Yu, Pooja Singh, Sam Yeaman, Sukanya Ramasamy, Joseph Tucker, Jillian M. Hagel, Qiushi Li, Xue Chen, Sonja M. Dunemann, Peter J. Facchini, Rongji Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway i
Autor:
Jillian M. Hagel, Raz Krizevski, Korey Kilpatrick, Yaron Sitrit, Frédéric Marsolais, Efraim Lewinsohn, Peter J. Facchini
Publikováno v:
Genetics and Molecular Biology, Vol 34, Iss 4, Pp 640-646 (2011)
Khat (Catha edulis Forsk.) is a flowering perennial shrub cultivated for its neurostimulant properties resulting mainly from the occurrence of (S)-cathinone in young leaves. The biosynthesis of (S)-cathinone and the related phenylpropylamino alkaloid
Externí odkaz:
https://doaj.org/article/ffb3ef24118040779b840d9b4f964366
Autor:
Rongji Chen, Peter J. Facchini, Mehran Dastmalchi, Limei Chang, Lisa Yu, Jillian M. Hagel, Xue Chen
Publikováno v:
Plant Physiol
Although opiate biosynthesis has been largely elucidated, and cell-to-cell transport has been long postulated, benzylisoquinoline alkaloid (BIA) transporters from opium poppy (Papaver somniferum) have not been reported. Investigation of a purine perm
Autor:
Sukanya Ramasamy, Peter J. Facchini, Limei Chang, Mehran Dastmalchi, Rongji Chen, Sam Yeaman, Jillian M. Hagel, Xue Chen
Publikováno v:
Nature Chemical Biology. 15:384-390
The isomerization of neopinone to codeinone is a critical step in the biosynthesis of opiate alkaloids in opium poppy. Previously assumed to be spontaneous, the process is in fact catalyzed enzymatically by neopinone isomerase (NISO). Without NISO th