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pro vyhledávání: '"Jillian M Di Muzio-Mower"'
Autor:
Diane M Rush, Jillian M Di Muzio-Mower, Carl F. Homnick, Elizabeth A. Lyle, I.-W. Chen, Marylou Juliano, Julie A. Krueger, Kari Vastag, Joseph P. Vacca, Bobby J. Lucas, Craig A. Coburn, Peter D. Williams, S. Dale Lewis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1069-1072
A new class of conformationally constrained thrombin inhibitors is described. These compounds contain a unique bicyclic pyridone scaffold which serves as a P3P2 dipeptide surrogate. The synthesis and antithrombotic activity of these inhibitors is rep