Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jillian L Shaw"'
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006043 (2016)
Stem cells depend critically on the surrounding microenvironment, or niche, for their maintenance and self-renewal. While much is known about how the niche regulates stem cell self-renewal and differentiation, mechanisms for how the niche is maintain
Externí odkaz:
https://doaj.org/article/ea42a374fe56436ea93e099f7f72164c
Autor:
Ayshwarya Subramanian, Katherine A. Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Carlos Arevalo, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Keller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Amanda Kotek, Giorgio Trivioli, Nathan Richoz, Mary B. Humphrey, Isabella G. Darby, Sarah J. Miller, Yingping Xu, Astrid Weins, Alexandra Chloe-Villani, Steven L. Chang, Matthias Kretzler, Orit Rosenblatt-Rosen, Jillian L. Shaw, Kurt A. Zimmerman, Menna R. Clatworthy, Aviv Regev, Anna Greka
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114253- (2024)
Summary: Diabetic kidney disease (DKD), the most common cause of kidney failure, is a frequent complication of diabetes and obesity, and yet to date, treatments to halt its progression are lacking. We analyze kidney single-cell transcriptomic profile
Externí odkaz:
https://doaj.org/article/c26ba69a6afe47bdbc7deb8408bb9ad1
Autor:
Jillian L Shaw, Karen T Chang
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003792 (2013)
Post-mortem brains from Down syndrome (DS) and Alzheimer's disease (AD) patients show an upregulation of the Down syndrome critical region 1 protein (DSCR1), but its contribution to AD is not known. To gain insights into the role of DSCR1 in AD, we e
Externí odkaz:
https://doaj.org/article/433633476eb8441eb11b4fe0f8e41ab8
Publikováno v:
Annual Review of Physiology. 85:407-423
Numerous trafficking and quality control pathways evolved to handle the diversity of proteins made by eukaryotic cells. However, at every step along the biosynthetic pathway, there is the potential for quality control system failure. This review focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06f92640ab4d0035f49f768b8573553c
https://doi.org/10.1146/annurev-physiol-031522-100639
https://doi.org/10.1146/annurev-physiol-031522-100639
Autor:
Nicolas Wieder, Juliana Coraor Fried, Choah Kim, Eriene-Heidi Sidhom, Matthew R. Brown, Jamie L. Marshall, Carlos Arevalo, Moran Dvela-Levitt, Maria Kost-Alimova, Jonas Sieber, Katlyn R. Gabriel, Julian Pacheco, Clary Clish, Hamdah Shafqat Abbasi, Shantanu Singh, Justine Rutter, Martine Therrien, Haejin Yoon, Zon Weng Lai, Aaron Baublis, Renuka Subramanian, Ranjan Devkota, Jonnell Small, Vedagopuram Sreekanth, Myeonghoon Han, Donghyun Lim, Anne E. Carpenter, Jason Flannick, Hilary Finucane, Marcia C. Haigis, Melina Claussnitzer, Eric Sheu, Beth Stevens, Bridget K. Wagner, Amit Choudhary, Jillian L. Shaw, Juan Lorenzo Pablo, Anna Greka
Publikováno v:
bioRxiv
SummaryCellular exposure to free fatty acids (FFA) is implicated in the pathogenesis of obesity-associated diseases. However, studies to date have assumed that a few select FFAs are representative of broad structural categories, and there are no scal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7daa44ca6aa3c52a2ff38c29c3f14b60
https://doi.org/10.1101/2023.02.19.529127
https://doi.org/10.1101/2023.02.19.529127
Publikováno v:
Mol Cell
Summary Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular membranes, and regulate energy metabolism. Questions remain as to which lipid species maintain metabolic homeostasis and which disrupt essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3b4186ea3ee6cc5951d608b9ac000b
https://doi.org/10.1016/j.molcel.2021.08.027
https://doi.org/10.1016/j.molcel.2021.08.027
Autor:
Ayshwarya Subramanian, Astrid Weins, Jamie L. Marshall, Elizabeth J. Grinkevich, Julia Waldman, Rosenblatt-Rosen O, Maria Alimova, Lan T. Nguyen, Fan Zhang, Yanfang Zhou, Purnell J, Jillian L. Shaw, Anna Greka, Slyper M, Steven L. Chang, Aviv Regev, Ayan Ghoshal, Alexandra-Chloé Villani, Katherine A. Vernon, Dubinsky D, Mónica S. Montesinos, Heller K, Danielle Dionne, Mike Cuoco, Sturner Sh
Mouse models are a tool for studying the mechanisms underlying complex diseases; however, differences between species pose a significant challenge for translating findings to patients. Here, we used single-cell transcriptomics and orthogonal validati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d5b09333d97e76b2d383fafd4bf366
https://doi.org/10.1101/2021.05.30.446342
https://doi.org/10.1101/2021.05.30.446342
Autor:
Keith Keller, Michelle Melanson, Choah Kim, Jillian L. Shaw, Luciene Ronco, Jamie L. Marshall, Katherine A. Vernon, Anna Greka, Juan Lorenzo B. Pablo, Seth L. Alper, Eriene-Heidi Sidhom, Florence F. Wagner, George C. Tsokos, Elizabeth J. Grinkevich, Moran Dvela-Levitt, Matthew Racette, Valeria Padovano, Julie Roignot, Frederick W.K. Tam, Abbe Clark, Ayshwarya Subramanian, Jean Santos, Alissa Campbell, Astrid Weins, Juan Gutierrez, Abhigyan Satyam, Andrew J.B. Watts, Stephen P. McAdoo, Maheswarareddy Emani, Silvana Bazua-Valenti, Estefanía Reyes-Bricio, Maria Kost-Alimova, Juliana Coraor, Brian T. Chamberlain, Patrick J. Byrne, Rebecca Thompson
Publikováno v:
Cell Reports Medicine
bioRxiv
bioRxiv
Drug repurposing is the only method capable of delivering treatments on the shortened time-scale required for patients afflicted with lung disease arising from SARS-CoV-2 infection. Mucin-1 (MUC1), a membrane-bound molecule expressed on the apical su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac05c8ae52c2a9ddd2eedf3972ff732d
http://hdl.handle.net/10044/1/83980
http://hdl.handle.net/10044/1/83980
Autor:
Alissa Campbell, Katherine A. Vernon, Rebecca Thompson, Anna Greka, Julie Roignot, Silvana Bazua-Valenti, Eriene-Heidi Sidhom, Florence F. Wagner, Seth L. Alper, Frederick W.K. Tam, Matthew Racette, Abbe Clark, Michelle Melanson, Ayshwarya Subramanian, Jean Santos, Choah Kim, Estefania Reyes Bricio, Astrid Weins, George C. Tsokos, Jillian L. Shaw, Elizabeth J. Grinkevich, Juliana Coraor, Andrew J. R. Watts, Lucienne V. Ronco, Juan Gutierrez, Keith Keller, Moran Dvela-Levitt, Maria Alimova, Maheswarareddy Emani, Juan Pablo, Abhigyan Satyam, Valeria Padovano, Stephen P. McAdoo, Brian T. Chamberlain, Jamie L. Marshall
Publikováno v:
Cell Reports Medicine
Summary Drug repurposing has the advantage of identifying potential treatments on a shortened timescale. In response to the pandemic spread of SARS-CoV-2, we took advantage of a high-content screen of 3,713 compounds at different stages of clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014b2c3625f75412ce10742b925a6461
https://doi.org/10.1101/2020.06.30.180380
https://doi.org/10.1101/2020.06.30.180380
Autor:
Catarina M. Quinzii, Giulio Kleiner, Clary B. Clish, Katherine A. Vernon, Keith Keller, Anna Greka, Choah Kim, May Theng Ting, Astrid Weins, Andrew J.B. Watts, Nicolas Wieder, Eriene-Heidi Sidhom, Maria Kost-Alimova, Matthew Racette, Elizabeth J. Grinkevich, Jillian L. Shaw, Estefanía Reyes-Bricio, Jamie L. Marshall, Fei Chen, Julian Avila-Pacheco
Publikováno v:
J Clin Invest
Mutations affecting mitochondrial coenzyme Q (CoQ) biosynthesis lead to kidney failure due to selective loss of podocytes, essential cells of the kidney filter. Curiously, neighboring tubular epithelial cells are spared early in disease despite highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf73d331567498a261ebe776f2ae76d
https://pubmed.ncbi.nlm.nih.gov/33444290
https://pubmed.ncbi.nlm.nih.gov/33444290