Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jillian Goines"'
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ
Autor:
Sandra Schrenk, Lindsay J. Bischoff, Jillian Goines, Yuqi Cai, Shruti Vemaraju, Yoshinobu Odaka, Samantha R. Good, Joseph S. Palumbo, Sara Szabo, Damien Reynaud, Catherine D. Van Raamsdonk, Richard A. Lang, Elisa Boscolo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Life-threatening vascular tumors can be associated with uncontrolled activity of the guanine nucleotide-binding protein subunit alpha (Gαq). Here, the authors develop a murine model for these tumors and show that MEK inhibition prevents formation of
Externí odkaz:
https://doaj.org/article/7cad600490c342d6b140a087bcb306ca
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Abstract Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM). Gain-of-function mutations in the tyros
Externí odkaz:
https://doaj.org/article/d60729f8db694524a763b01f44aa65cc
Autor:
Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D. Le Cras
Publikováno v:
Angiogenesis. 25:331-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7064664e88f9f0520fd4cb852f6cc832
https://doi.org/10.1007/s10456-022-09836-7
https://doi.org/10.1007/s10456-022-09836-7
Autor:
Nora Lakes, Denise M. Adams, Patricia A. Pastura, Elisa Boscolo, Adrienne M. Hammill, Jillian Goines, Timothy D. Le Cras
Publikováno v:
Angiogenesis
Capillary lymphatic venous malformations (CLVM) are complex vascular anomalies characterized by aberrant and enlarged lymphatic and blood vessels. CLVM appear during fetal development and enlarge after birth, causing life-long complications such as c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cf948748f6e0a193f3276a3a658448
https://doi.org/10.1007/s10456-020-09722-0
https://doi.org/10.1007/s10456-020-09722-0
Autor:
Elisa, Boscolo, Patricia, Pastura, Sandra, Schrenk, Jillian, Goines, Rachael, Kang, Devin, Pillis, Punam, Malik, Timothy D, Le Cras
Publikováno v:
Angiogenesis
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRAS(Q61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be78c0ad8a39011de89b237b5ecea5fc
https://pubmed.ncbi.nlm.nih.gov/35391614
https://pubmed.ncbi.nlm.nih.gov/35391614
Autor:
Elisa Boscolo, Xian Li, Adam Lane, Lars Brichta, Timothy D. Le Cras, Jillian Goines, Yuqi Cai, Patricia A. Pastura
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective— Venous malformations (VMs) arise from developmental defects of the vasculature and are characterized by massively enlarged and tortuous venous channels. VMs grow commensurately
Objective— Venous malformations (VMs) arise from developmental defects of the vasculature and are characterized by massively enlarged and tortuous venous channels. VMs grow commensurately
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb9654fa8f0dded168de832cbe7c646
http://europepmc.org/articles/PMC6392210
http://europepmc.org/articles/PMC6392210
Autor:
Jillian Goines, Elisa Boscolo
Publikováno v:
Methods in Molecular Biology ISBN: 9781071609156
Methods Mol Biol
Methods Mol Biol
Xenograft models allow for an in vivo approach to monitor cellular functions within the context of a host microenvironment. Here we describe a protocol to generate a xenograft model of venous malformation (VM) based on the use of human umbilical vein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4bbe9da366d1c9cc4fb121835393b9
https://doi.org/10.1007/978-1-0716-0916-3_13
https://doi.org/10.1007/978-1-0716-0916-3_13
Publikováno v:
J Vis Exp
Venous malformation (VM) is a vascular anomaly that arises from impaired development of the venous network resulting in dilated and often dysfunctional veins. The purpose of this article is to carefully describe the establishment of a murine xenograf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a76be107c3aad71862e8e417d1788b7
https://doi.org/10.3791/61501-v
https://doi.org/10.3791/61501-v
Autor:
Megan Metcalf, Yuqi Cai, Elisa Boscolo, Steven J. Fishman, Xian Li, Paula S. Mobberley-Schuman, Adrienne M. Hammill, Denise M. Adams, Jillian Goines
Publikováno v:
Angiogenesis
Vascular malformations are defects caused by the abnormal growth of the vasculature. Among them, venous malformation (VM) is an anomaly characterized by slow-flow vascular lesions with abnormally shaped veins, typically in sponge-like configuration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32b5724f3c7371a145c5054f70a62d1
http://europepmc.org/articles/PMC6203618
http://europepmc.org/articles/PMC6203618
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f5663a29b4112c83566b3dd2c9ad0f
https://doi.org/10.1096/fasebj.2019.33.1_supplement.527.3
https://doi.org/10.1096/fasebj.2019.33.1_supplement.527.3