Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Jillian G, Baker"'
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract α2‐adrenoceptors, (α2A, α2B and α2C‐subtypes), are Gi‐coupled receptors. Central activation of brain α2A and α2C‐adrenoceptors is the main site for α2‐agonist mediated clinical responses in hypertension, ADHD, muscle spasm a
Externí odkaz:
https://doaj.org/article/62f574fc49f84753a64d6f5b7905307a
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract α2‐Adrenoceptors, subdivided into α2A, α2B, and α2C subtypes and expressed in heart, blood vessels, kidney, platelets and brain, are important for blood pressure, sedation, analgesia, and platelet aggregation. Brain α2C‐adrenoceptor
Externí odkaz:
https://doaj.org/article/4748e39534774fa8b107ecb93e50747a
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract Highly selective drugs offer a way to minimize side‐effects. For agonist ligands, this could be through highly selective affinity or highly selective efficacy, but this requires careful measurements of intrinsic efficacy. The α1‐adrenoc
Externí odkaz:
https://doaj.org/article/7a84ce3fee584887aa48f7f483492269
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 4, Pp n/a-n/a (2020)
Abstract α1‐adrenoceptor antagonists are widely used for hypertension (eg, doxazosin) and benign prostatic hypertrophy (BPH, eg, tamsulosin). Some antidepressants and antipsychotics have been reported to have α1 affinity. This study examined 101
Externí odkaz:
https://doaj.org/article/510f385e83cc4e3dba11141b3a79376c
Publikováno v:
Molecular Pharmacology. 103:89-99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cdde81830eca65db23a3a4d4e0311dc
https://doi.org/10.1124/molpharm.122.000583
https://doi.org/10.1124/molpharm.122.000583
Autor:
Roger Summers, Dianne Perez, Sergio Parra, Kenneth P. Minneman, Martin C. Michel, Rebecca Hills, J. Paul Hieble, Robert M. Graham, Douglas C. Eikenburg, David B. Bylund, Richard A. Bond, Poornima Balaji, Jillian G. Baker
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The nomenclature of the Adrenoceptors has been agreed by the NC-IUPHAR Subcommittee on Adrenoceptors [64, 194]. Adrenoceptors, α1 The three α1-adrenoceptor subtypes α1A, α1B and α1D are activated by the endogenous agonists (-)-adrenaline and (-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e932f20e992d7b20dde686492b711dbc
https://doi.org/10.2218/gtopdb/f4/2023.1
https://doi.org/10.2218/gtopdb/f4/2023.1
Autor:
Jacopo Tricomi, Luca Landini, Valentina Nieddu, Ugo Cavallaro, Jillian G. Baker, Athanasios Papakyriakou, Barbara Richichi
Publikováno v:
European journal of medicinal chemistry. 246
Biomedical applications of molecules that are able to modulate β-adrenergic signaling have become increasingly attractive over the last decade, revealing that β-adrenergic receptors (β-ARs) are key targets for a plethora of therapeutic interventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b824d84d096972c54742aedcf91980c5
https://pubmed.ncbi.nlm.nih.gov/36495629
https://pubmed.ncbi.nlm.nih.gov/36495629
Autor:
Michelle L. Halls, Edoardo Botteri, Alexandra I. Ziegler, Ryan D. Gillis, Ni Chun Chung, Aeson Chang, Jillian G. Baker, Erica K. Sloan, Bettina K. Andreassen, Cindy K. Pon, David M. Shackleford
Publikováno v:
European Journal of Cancer. 147:106-116
Purpose The sympathetic nervous system drives breast cancer progression through β-adrenergic receptor signalling. This discovery has led to the consideration of cardiac β-blocker drugs as novel strategies for anticancer therapies. Carvedilol is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60510db7edaf77f3f69760d5cf34c12
https://doi.org/10.1016/j.ejca.2021.01.029
https://doi.org/10.1016/j.ejca.2021.01.029
Autor:
Frank Balzer, Florent Chevillard, Jillian G. Baker, Ádám Andor Kelemen, Vivien A Aranyodi, György M. Keserű, Peter Kolb
Publikováno v:
Chemical Communications. 57:10516-10519
We developed a docking-based fragment evolution approach that extends orthosteric fragments towards a less conserved secondary binding pocket of GPCRs. Evaluating 13 000 extensions for the β1- and β2-adrenergic receptors we synthesized and tested 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b503925d540c183a6b860feea03147
https://doi.org/10.1039/d1cc04636e
https://doi.org/10.1039/d1cc04636e
Autor:
Peter M. Fischer, jillian G. baker, Stephen J. Hill, Christophe Fromont, Sheila M. Gardiner, Barrie Kellam, Kevin S.J. Thompson, Marjorie Bruder
Publikováno v:
ACS Pharmacology & Translational Science. 3:737-748
For disorders of the skin, eyes, ears, and respiratory tract, topical drugs, delivered directly to the target organ, are a therapeutic option. Compared with systemic oral therapy, the benefits of topical treatments include a faster onset of action, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4dd72055cb7f074ce8fb5e6987808c
https://doi.org/10.1021/acsptsci.0c00051
https://doi.org/10.1021/acsptsci.0c00051