Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jillian F. Evans"'
Autor:
Susan M. Lin, Ryan Rue, Akansha Goel, Kseniya Obraztsova, Alexander R. Mukhitov, Kanth Swaroop Vanka, Carly J. Smith, Maria C. Basil, Laura T. Ferguson, Joseph D. Planer, Edward Cantu, Grazyna Kwapiszewska, Edward E. Morrisey, Jillian F. Evans, Vera P. Krymskaya
Pulmonary vascular remodeling is the key structural abnormality in pulmonary hypertension (PH). Mechanistic target of rapamycin (mTOR) has long been suspected to play a role in the development of pulmonary vascular remodeling. However, underlying cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da666a5cd4a35e3f11b5da871f4e9bda
https://doi.org/10.1101/2022.10.08.511300
https://doi.org/10.1101/2022.10.08.511300
Publikováno v:
Clinical & Experimental Allergy Reviews. 1:205-209
Autor:
Robert Zamboni, Jocelyne Guay, Stella Charleson, M.D. Percival, Jean-Pierre Falgueyret, Joseph A. Mancini, Susan Boyce, Michael J. Therien, Lijing Xu, R. Gordon, Stacia Kargman, Anthony W. Ford-Hutchinson, Gillian Greig, Marc Ouellet, Denis Riendeau, Petpiboon Prasit, Serge Leger, Zhaoyin Wang, J.K. Webb, Diane Ethier, Chi-Chung Chan, Gary P. O'Neill, Robert N. Young, Ian W. Rodger, Wanda Cromlish, Christine Brideau, Jillian F. Evans, Michael J. Gresser, E. Wong
Publikováno v:
British Journal of Pharmacology. 121:105-117
1. DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furan one) was identified as a novel orally active and highly selective cyclo-oxygenase-2 (COX-2) inhibitor. 2. In CHO cells stably transfected with human COX isozymes, DFU inh
Autor:
M Cartwright, Stella Charleson, J Frank, Jillian F. Evans, Denis Riendeau, Stacia Kargman, Joseph A. Mancini, Gary P. O'Neill
Publikováno v:
Gastroenterology. 111:445-454
BACKGROUND & AIMS: In the gastrointestinal tract, prostaglandins are implicated as important mediators of normal physiological processes. Prostaglandin G/H synthase (PGHS) is the first enzyme leading to the formation of prostaglandins. Two forms exis
Autor:
Irwin I. Singer, L. Hearn, Philip J. Vickers, Diane Ethier, Jillian F. Evans, Stella Charleson, S Scott, J A Heibein, J. W. Woods
Publikováno v:
The Journal of Experimental Medicine
The intracellular distribution of the enzyme 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) in resting and ionophore-activated human leukocytes has been determined using immuno-electronmicroscopic labeling of ultrathin frozen sect
Autor:
Yves Girard, C. S. Mcfarlane, Jillian F. Evans, Denis Riendeau, Donald W. Nicholson, H. Piechuta, Stella Charleson, Stacia Kargman, Dwight Macdonald, Karst Hoogsteen, John Scheigetz, John H. Hutchinson, Thomas R. Jones, Michael J. Therien, Jean-Pierre Falgueyret
Publikováno v:
ChemInform. 27
Autor:
JS Swaney, TJ Seiders, CS Baccei, P Fagan, Jillian F. Evans, A M Santini, PC Prodanovich, TA Parr, J. H. Hutchinson, LD Correa, DS Lorrain, RA Bundey, Petpiboon Prasit, C Chapman, KJ Stebbins
The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA(1), in treating lung fibrosis We evaluated the in vitro and in vivo pharmacological properties of the high affinity, selective, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb659d2677e2bbd216e7d64f6d7bacc
https://europepmc.org/articles/PMC2936842/
https://europepmc.org/articles/PMC2936842/
Publikováno v:
The Journal of Cell Biology
In a previous study, osteosarcoma cells expressing both 5-lipoxygenase (5-LO) and 5 lipoxygenase-activating protein (FLAP) synthesized leukotrienes upon A23187 stimulation (Dixon, R. A. F., R. E. Diehl, E. Opas, E. Rands, P. J. Vickers, J. F. Evans,
Autor:
L.Y. Choo, Stella Charleson, Petpiboon Prasit, Denis Riendeau, H. Piechuta, Jillian F. Evans, Richard G. Ball, John H. Hutchinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1699-1702
The combination of a 5-phenylpyridine substituent and a novel, substituted thiopyrano[2,3,4-c,d]indole ring system yields a potent and selective 5-lipoxygenase inhibitor, L-689,065.
Autor:
Denis Riendeau, Rejean Fortin, Christine Brideau, M. Belley, Robert Zamboni, Stella Charleson, Anthony W. Ford-Hutchinson, Jocelyne Guay, Chi-Chung Chan, Robert N. Young, John W. Gillard, Jillian F. Evans, Serge Leger, Petpiboon Prasit, John H. Hutchinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1395-1398
The evolution of a quinoline based FLAP inhibitor, L-674,636, into a novel quinoline-indole hybrid compound: MK0591, is described. The new series of compounds are more potent, particularly in binding to FLAP, in inhibiting LTB4 biosynthesis in stimul