Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jillian C. Vanover"'
Autor:
Erin M. Wolf Horrell, Mary C. Boulanger, Stuart G. Jarrett, John A. D'Orazio, Jillian C. Vanover, Yue Zou, Perry A. Christian
Publikováno v:
Molecular Cell. 54:999-1011
The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313c8671f8a7c7efbd701308c9277e59
https://doi.org/10.1016/j.molcel.2014.05.030
https://doi.org/10.1016/j.molcel.2014.05.030
Publikováno v:
Journal of Visualized Experiments.
Fairness of skin, UV sensitivity and skin cancer risk all correlate with the physiologic function of the melanocortin 1 receptor, a Gs-coupled signaling protein found on the surface of melanocytes. Mc1r stimulates adenylyl cyclase and cAMP production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fe4a494777de0ceb71b801ce798588
https://doi.org/10.3791/50670-v
https://doi.org/10.3791/50670-v
Autor:
Stuart G, Jarrett, Erin M Wolf, Horrell, Perry A, Christian, Jillian C, Vanover, Mary C, Boulanger, Yue, Zou, John A, D'Orazio
Publikováno v:
Mol Cell
The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic transmembrane receptor involved in pigmentation, adaptive tanning, and melanoma resistance. We report MC1R-mediated or pharmacologically-induced cAMP signaling promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdd93c10dc00a0779060e6283b6a6534
https://pubmed.ncbi.nlm.nih.gov/36400011
https://pubmed.ncbi.nlm.nih.gov/36400011
Autor:
Martin McMahon, Candace R. Guerrero, Jin Wang, Mai P. Hoang, Jochen K. Lennerz, Marcus Bosenberg, Jennifer A. Lo, Jennifer A. Wargo, John A. D'Orazio, Jillian C. Vanover, Kathleen C. Robinson, Ann M. Morgan, Xi Luo, Yinsheng Wang, Devarati Mitra, Kevin M. Haigis, Daniel A. Haber, David E. Fisher, Martin C. Mihm, Suprabha P. Devi
Publikováno v:
Nature
People with pale skin, red hair, freckles and an inability to tan--the 'red hair/fair skin' phenotype--are at highest risk of developing melanoma, compared to all other pigmentation types. Genetically, this phenotype is frequently the product of inac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0c949c30d0c741af0dc88d1a69e843
https://pubmed.ncbi.nlm.nih.gov/23123853
https://pubmed.ncbi.nlm.nih.gov/23123853
Publikováno v:
Journal of Carcinogenesis & Mutagenesis.
As a group, malignancies of the skin are the most commonly diagnosed cancers, with over a million cases each year identified in the United States alone. While the keratinocyte malignancies – basal cell carcinoma (BCC) and squamous cell carcinoma (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acde6aac7fa2d07ad0c09e24742a03bc
https://doi.org/10.4172/2157-2518.s4-001
https://doi.org/10.4172/2157-2518.s4-001
Autor:
Laura Hamilton, Shosuke Ito, John A. D'Orazio, Jillian C. Vanover, Kazumasa Wakamatsu, Malinda Spry
Publikováno v:
Pigment cellmelanoma research. 22(6)
We previously reported a transgenic animal model of variant pigmentation based on epidermal expression of stem cell factor (SCF) and well-characterized coat color genes bred into the C57Bl/6 background. In this system, constitutive expression of SCF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b11984dcda02b324274852efd05989
https://pubmed.ncbi.nlm.nih.gov/19682281
https://pubmed.ncbi.nlm.nih.gov/19682281
Autor:
Timothy L. Scott, Osama Abona-Ama, Kazumasa Wakamatsu, John A. D'Orazio, Malinda Spry, Jillian C. Vanover, Shosuke Ito
Publikováno v:
Pigment cellmelanoma research. 22(2)
We previously reported that topical application of forskolin to the skin of fair-skinned MC1R-defective mice with epidermal melanocytes resulted in accumulation of eumelanin in the epidermis and was highly protective against UV-mediated cutaneous inj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b96ca1f59eb1d8665d3fb2939ed613
https://pubmed.ncbi.nlm.nih.gov/19087231
https://pubmed.ncbi.nlm.nih.gov/19087231
Autor:
Perry A. Christian, John A. D'Orazio, Jillian C. Vanover, Yue Zou, Stuart G. Jarrett, Erin M. Wolf Horrell, Mary C. Boulanger
Publikováno v:
Cancer Research. 75:A34-A34
The melanocortin 1 receptor (MC1R), which signals through cAMP, is a melanocytic Gs-coupled transmembrane receptor activated by binding to its high-affinity ligand, α-melanocyte stimulating hormone (MSH). Besides influencing pigment phenotype and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7016e5dc3e57e10be53c95713e97d09
https://doi.org/10.1158/1538-7445.mel2014-a34
https://doi.org/10.1158/1538-7445.mel2014-a34