Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jillian, Spangler"'
Autor:
Jinbao Xiang, Ming Shang, Yu Kawamata, Helena Lundberg, Solomon Reisberg, Miao Chen, Pavel Mykhailiuk, Gregory Beutner, Michael Collins, Alyn Davies, Matthew Del Bel, Gary Gallego, Jillian Spangler, Jeremy T. Starr, Shouliang Yang, Donna Blackmond, Phil Baran
Hindered ethers represent an underexplored area of chemical space due to the difficulty and inoperability associated with conventional reactions, despite the high-value of such structural motifs in a variety of societal applications. Demonstrated her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffbc16c64c698859d534d7ba2285def
https://doi.org/10.26434/chemrxiv.8144294
https://doi.org/10.26434/chemrxiv.8144294
Autor:
Pei-Pei, Kung, Patrick, Bingham, Alexei, Brooun, Michael, Collins, Ya-Li, Deng, Dac, Dinh, Connie, Fan, Ketan S, Gajiwala, Rita, Grantner, Hovhannes J, Gukasyan, Wenyue, Hu, Buwen, Huang, Robert, Kania, Susan E, Kephart, Cody, Krivacic, Robert A, Kumpf, Penney, Khamphavong, Manfred, Kraus, Wei, Liu, Karen A, Maegley, Lisa, Nguyen, Shijian, Ren, Dan, Richter, Robert A, Rollins, Neal, Sach, Shikhar, Sharma, John, Sherrill, Jillian, Spangler, Albert E, Stewart, Scott, Sutton, Sean, Uryu, Dominique, Verhelle, Hui, Wang, Shuiwang, Wang, Martin, Wythes, Shuibo, Xin, Shinji, Yamazaki, Huichun, Zhu, JinJiang, Zhu, Luke, Zehnder, Martin, Edwards
Publikováno v:
Journal of medicinal chemistry. 61(3)
A new series of lactam-derived EZH2 inhibitors was designed via ligand-based and physicochemical-property-based strategies to address metabolic stability and thermodynamic solubility issues associated with previous lead compound 1. The new inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47b5a14cd255ea7adedb733daa3e1969
https://pubmed.ncbi.nlm.nih.gov/29211475
https://pubmed.ncbi.nlm.nih.gov/29211475
Publikováno v:
Journal of the American Chemical Society; 4/8/2015, Vol. 137 Issue 13, p4391-4397, 7p