Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

Autor: Stephanus T. Malherbe, Ray Y. Chen, Patrick Dupont, Ilse Kant, Magdalena Kriel, André G. Loxton, Bronwyn Smith, Caroline G. G. Beltran, Susan van Zyl, Shirely McAnda, Charmaine Abrahams, Elizna Maasdorp, Alex Doruyter, Laura E. Via, Clifton E. Barry, David Alland, Stephanie Griffith- Richards, Annare Ellman, Thomas Peppard, John Belisle, Gerard Tromp, Katharina Ronacher, James M. Warwick, Jill Winter, Gerhard Walzl

Publikováno v: EJNMMI Research, Vol 10, Iss 1, Pp 1-15 (2020)

Abstract Background There is a growing interest in the use of F-18 FDG PET-CT to monitor tuberculosis (TB) treatment response. Tuberculosis lung lesions are often complex and diffuse, with dynamic changes during treatment and persisting metabolic act

Externí odkaz: https://doaj.org/article/5d6e9e74073f4ab0a71f8f008e07ff38

The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

Autor: Trust Odia, Stephanus T. Malherbe, Stuart Meier, Elizna Maasdorp, Léanie Kleynhans, Nelita du Plessis, Andre G. Loxton, Daniel E. Zak, Ethan Thompson, Fergal J. Duffy, Helena Kuivaniemi, Katharina Ronacher, Jill Winter, Gerhard Walzl, Gerard Tromp, the Catalysis TB-Biomarker Consortium, André G. Loxton, Annare Ellman, Bronwyn Smith, Caroline G. G. Beltran, Clifton E. Barry, David Alland, Friedrich Thienemann, James M. Warwick, Kim Stanley, Ilse Kant, Lani Thiart, Lance A. Lucas, Laura E. Via, Lori E. Dodd, Magdalena Kriel, Nelita Plessis Du, Patrick Dupont, Ray Y. Chen, Robert J. Wilkinson, Shubhada Shenai, Stephanie Griffith-Richards

Publikováno v: Frontiers in Immunology, Vol 11 (2021)

Pulmonary tuberculosis (PTB) is characterized by lung granulomas, inflammation and tissue destruction. Here we used within-subject peripheral blood gene expression over time to correlate with the within-subject lung metabolic activity, as measured by

Externí odkaz: https://doaj.org/article/70919f9b260c42568cd12c831dc3bbde

A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images

Autor: Stephanus T. Malherbe, Patrick Dupont, Ilse Kant, Petri Ahlers, Magdalena Kriel, André G. Loxton, Ray Y. Chen, Laura E. Via, Friedrich Thienemann, Robert J. Wilkinson, Clifton E. Barry, Stephanie Griffith-Richards, Annare Ellman, Katharina Ronacher, Jill Winter, Gerhard Walzl, James M. Warwick, the Catalysis Biomarker Consortium

Publikováno v: EJNMMI Research, Vol 8, Iss 1, Pp 1-14 (2018)

Abstract Background There is a growing interest in the use of 18F-FDG PET-CT to monitor tuberculosis (TB) treatment response. However, TB causes complex and widespread pathology, which is challenging to segment and quantify in a reproducible manner.

Externí odkaz: https://doaj.org/article/1f9bb2af447e42cc8e1a43a7b0bd78d0

Bacterial Loads Measured by the Xpert MTB/RIF Assay as Markers of Culture Conversion and Bacteriological Cure in Pulmonary TB.

Autor: Shubhada Shenai, Katharina Ronacher, Stefanus Malherbe, Kim Stanley, Magdalena Kriel, Jill Winter, Thomas Peppard, Charles E Barry, Jing Wang, Lori E Dodd, Laura E Via, Clifton E Barry, Gerhard Walzl, David Alland

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160062 (2016)

Biomarkers are needed to monitor tuberculosis (TB) treatment and predict treatment outcomes. We evaluated the Xpert MTB/RIF (Xpert) assay as a biomarker for TB treatment during and at the end of the 24 weeks therapy.Sputum from 108 HIV-negative, cult

Externí odkaz: https://doaj.org/article/3b4244efac984fadae2e704b9d4bf604

Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy

Autor: Stephanus T. Malherbe, James Gallant, Jill Winter, Nelita du Plessis, Andre G. Loxton, Bavesh D. Kana, Tiaan Heunis, Gerhard Walzl, Matthias Trost, Rouxjeane Venter, Caroline G. G. Beltran

Publikováno v: Beltran, C G G, Heunis, T, Gallant, J, Venter, R, du Plessis, N, Loxton, A G, Trost, M, Winter, J, Malherbe, S T, Kana, B D & Walzl, G 2020, ' Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy ', Frontiers in Cellular and Infection Microbiology, vol. 10, 443, pp. 1-14 . https://doi.org/10.3389/fcimb.2020.00443
Frontiers in Cellular and Infection Microbiology, 10:443, 1-14. Frontiers Media
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

Mycobacterium tuberculosis (Mtb) is extremely recalcitrant to antimicrobial chemotherapy requiring 6 months to treat drug-sensitive tuberculosis (TB). Despite this, 4–10% of cured patients will develop recurrent disease within 12 months after compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5197f271c41d94d7d0851796f23b554
https://research.vu.nl/en/publications/b522b3c4-8c1b-43b9-9043-8b4e73499769