Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jill T Ferlan"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:187-195
Competitive inhibitors of dihydrofolate reductase (DHFR) are used in chemotherapy or prophylaxis of many microbial pathogens, including the eukaryotic parasites Plasmodium falciparum and Toxoplasma gondii . Unfortunately, point mutations in the DHFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84924b8fc4baf2bdf4d536d6d2b2f6bb
https://doi.org/10.1128/aac.45.1.187-195.2001
https://doi.org/10.1128/aac.45.1.187-195.2001
Autor:
Zhiyu Li, Patrice Sellers, Sean T. Prigge, Jill T Ferlan, Malcolm J. Gardner, Shamira J. Shallom, Norman C. Waters, Cassandra L. Woodard, Lan Wei, Karen M. Kopydlowski, Patricia J. Lee, Tadeusz Guszczynski
Publikováno v:
Molecular and biochemical parasitology. 123(2)
The genome of the malaria parasite, Plasmodium falciparum, appears to contain the proteins necessary for a Type II dissociated fatty acid biosynthetic system. Here we report the functional characterization of two proteins from this system. Purified r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c25d6107d6ed4c8646724804116e032
https://pubmed.ncbi.nlm.nih.gov/12270624
https://pubmed.ncbi.nlm.nih.gov/12270624
Autor:
Jill T. Ferlan, Ihuoma Nicole Okezie, Carol Hopkins Sibley, Somnath Mookherjee, Lucy Fulgence
Publikováno v:
Molecular and biochemical parasitology. 113(1)
Inhibitors of dihydrofolate reductase (DHFR) have been a mainstay of chemotherapy of falciparum malaria for >50 years. Unfortunately, point mutations in DHFR are the major cause of resistance to drugs of this class and mutations have rapidly diminish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae24ee8bf42e4826da2ace155fbd5e1
https://pubmed.ncbi.nlm.nih.gov/11254962
https://pubmed.ncbi.nlm.nih.gov/11254962