Výsledky vyhledávání - "Jill R. Keeler"

Autoionization reaction of phosgene (OCC12) studied by electron paramagnetic resonance/spin trapping techniques

Autor: Richard R. Stotts, Felix Feliciano, Susan R. Millette, Carmen M. Arroyo, Jill R. Keeler, Dana L. Kolb

Publikováno v: Journal of Biochemical Toxicology. 8:107-110

The reaction of phosgene with ni-trone spin traps was investigated using electron paramagnetic resonance (EPR)/spin trapping techniques. Evidence for the intermediacy of a carba-moyl monochloride intermediate was obtained. Isotopic substitution of 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcd71a7bb285db819f399ae9e963431b
https://doi.org/10.1002/jbt.2570080208

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Interactions between Nerve Agent Pretreatment and Drugs Commonly Used in Combat Anesthesia

Autor: Jill R. Keeler

Publikováno v: Military Medicine. 155:527-533

Pyridostigmine is a drug stockpiled for oral pretreatment of nerve agent exposure; however, the soldier is still vulnerable to conventional warfare injuries, which are commonly associated with the need for anesthesia and surgery. In order to determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f8678ebb3bc2f3db15c0b2dd3bdc9bf
https://doi.org/10.1093/milmed/155.11.527

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Estimation of the Lct50 of Phosgene in Sheep

Autor: Holcombe H. Hurt, W.J. Lennox, James B. Nold, Jill R. Keeler

Publikováno v: Drug and Chemical Toxicology. 13:229-239

In all species previously studied, inhalation of toxic doses of phosgene results in varying degrees of pulmonary edema, often after a symptom-free period. The sheep is an anatomically unique animal in which to study the development of pulmonary edema

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adb4d38b71c5eee8c0b85cd8d8defbc
https://doi.org/10.3109/01480549009018123

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Phosgene-Induced Lung Injury in Sheep

Autor: Holcombe H. Hurt, Jill R. Keeler, Kevin D. Corcoran, Theresa M. Tezak-Reid, James B. Nold

Publikováno v: Inhalation Toxicology. 2:391-406

Inhalation of toxic doses of phosgene results in varying degrees of pulmonary edema, often after a symptom-free period. The sheep is an anatomically suitable animal in which to study the development of pulmonary edema during that symptom-free period.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1deb22ee20213b3cb25cd6f7aa6f7638
https://doi.org/10.3109/08958379009145265

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Reactive oxygen species produced in metal-catalyzed oxidation of bis(trifluoromethyl)disulfide and protection by ZE

Autor: Richard L. McCarthy, Theodore S. Moran, Stephen D. Kirby, Robert J. Werrlein, Jill R. Keeler, Carmen M. Arroyo

Publikováno v: Journal of toxicology and environmental health. 41(3)

Bis(trifluoromethyl)disulfide (TFD), used as an industrial fumigant, was found to generate a thiyl free radical as seen by EPR/spin trapping. Oxygen appears to be an absolute requirement for radical production. The results obtained in this investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb985dce1821785e949be646bcc16d46
https://pubmed.ncbi.nlm.nih.gov/8126753

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Pathophysiologic Mechanisms of Three Pulmonary Edemagenic Compounds: The Role of Toxic Oxygen Species

Autor: Suzanne A. Hernandez, Jill R. Keeler, Holcombe H. Hurt, Wallace B. Baze, Theresa M. Tezak-Reid

Inhalation of phosgene (CG), perfluoroisobutylene (PFIB), or bis(trifluoromethyl)disulfide (TFD) results in the production of pulmonary edema, but the mechanism involved has not been determined. To study this mechanism, the effects of eight drugs tho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6be23718f0adeaa7b1f50b5bd0028557
https://doi.org/10.21236/ada251135

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More on Desert Storm-Reply

Autor: Michael A. Dunn, Jill R. Keeler, Charles G. Hurst

Publikováno v: JAMA: The Journal of the American Medical Association. 266:3283

In Reply. —We limit our response to Dr Sarno to issues raised about pyridostigmine. Clearly, this is of concern as the number of women in military service increases and the threat of chemical warfare in the world persists. Since the safety of pyrid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adaecac6cc8f8ecddde12f494a9aaf2c
https://doi.org/10.1001/jama.1991.03470230040016

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Pyridostigmine Used as a Nerve Agent Pretreatment Under Wartime Conditions

Autor: Jill R. Keeler, Charles G. Hurst, Michael A. Dunn

Publikováno v: JAMA: The Journal of the American Medical Association. 266:693

Objective. —To determine the adverse effects of pretreatment with pyridostigmine bromide for nerve agent exposure during wartime. Design. —A retrospective study. Setting. —Southwest Asia. Participants. —Personnel who provided medical support

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::871828b01b89c9f41f990673b018aa17
https://doi.org/10.1001/jama.1991.03470050093029

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Bulbospinal substance P and sympathetic regulation of the cardiovascular system: A review

Autor: Cinda J. Helke, Jill R. Keeler, Clivel G. Charlton

Publikováno v: Peptides. 6:69-74

The neurotransmitter role of substance P in mediating sympathoexcitatory effects in the spinal cord and cardiovascular effects elicited from the ventral medulla is presented. SP neurons located in the ventral medulla project to the intermediolateral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7850beffcf601ad561ff8bcc52b58a97
https://doi.org/10.1016/0196-9781(85)90137-8

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