The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra.

Autor: Margaret I Davis, Jill R Crittenden, Austin Y Feng, David A Kupferschmidt, Alipi Naydenov, Nephi Stella, Ann M Graybiel, David M Lovinger

Publikováno v: PLoS ONE, Vol 13, Iss 2, p e0191436 (2018)

Presynaptic cannabinoid-1 receptors (CB1-R) bind endogenous and exogenous cannabinoids to modulate neurotransmitter release. CB1-Rs are expressed throughout the basal ganglia, including striatum and substantia nigra, where they play a role in learnin

Externí odkaz: https://doaj.org/article/e5000d81da134faebf139dcaee89aa74

Levodopa-induced dyskinesia is associated with increased thyrotropin releasing hormone in the dorsal striatum of hemi-parkinsonian rats.

Autor: Ippolita Cantuti-Castelvetri, Ledia F Hernandez, Christine E Keller-McGandy, Lauren R Kett, Alex Landy, Zane R Hollingsworth, Esen Saka, Jill R Crittenden, Eduardo A Nillni, Anne B Young, David G Standaert, Ann M Graybiel

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e13861 (2010)

Dyskinesias associated with involuntary movements and painful muscle contractions are a common and severe complication of standard levodopa (L-DOPA, L-3,4-dihydroxyphenylalanine) therapy for Parkinson's disease. Pathologic neuroplasticity leading to

Externí odkaz: https://doaj.org/article/dc2baa9047584c208c2b171d8395cf7b

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors

Autor: Jill R. Crittenden, Shenyu Zhai, Magdalena Sauvage, Takashi Kitsukawa, Eric Burguière, Morgane Thomsen, Hui Zhang, Cinzia Costa, Giuseppina Martella, Veronica Ghiglieri, Barbara Picconi, Karen A. Pescatore, Ellen M. Unterwald, Walker S. Jackson, David E. Housman, S. Barak Caine, David Sulzer, Paolo Calabresi, Anne C. Smith, D. James Surmeier, Ann M. Graybiel

Publikováno v: Neurobiology of Disease, Vol 158, Iss , Pp 105473- (2021)

CalDAG-GEFI (CDGI) is a protein highly enriched in the striatum, particularly in the principal spiny projection neurons (SPNs). CDGI is strongly down-regulated in two hyperkinetic conditions related to striatal dysfunction: Huntington's disease and l

Externí odkaz: https://doaj.org/article/dcb665d27eb248cbbbad7e35d7e418a7

Drosophila mef2 is essential for normal mushroom body and wing development

Autor: Jill R. Crittenden, Efthimios M. C. Skoulakis, Elliott S. Goldstein, Ronald L. Davis

Publikováno v: Biology Open, Vol 7, Iss 9 (2018)

MEF2 (myocyte enhancer factor 2) transcription factors are found in the brain and muscle of insects and vertebrates and are essential for the differentiation of multiple cell types. We show that in the fruit fly Drosophila, MEF2 is essential for the

Externí odkaz: https://doaj.org/article/8342474e33894cf48757ef22c7b25e0e

Effects of acute and repeated administration of the selective M4 PAM VU0152099 on cocaine versus food choice in male rats

Autor: Morgane Thomsen, Jill R. Crittenden, Craig W. Lindsley, Ann M. Graybiel

Publikováno v: Thomsen, M, Crittenden, J R, Lindsley, C W & Graybiel, A M 2022, ' Effects of acute and repeated administration of the selective M 4 PAM VU0152099 on cocaine versus food choice in male rats ', Addiction Biology, vol. 27, no. 2, e13145 . https://doi.org/10.1111/adb.13145

Ligands that stimulate muscarinic acetylcholine receptors 1 and 4 (M1, M4) have shown promising effects as putative pharmacotherapy for cocaine use disorder in rodent assays. We have previously shown reductions in cocaine effects with acute M4 stimul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43933e4fe35ffcea326090994be2d23
https://curis.ku.dk/portal/da/publications/effects-of-acute-and-repeated-administration-of-the-selective-m4-pam-vu0152099-on-cocaine-versus-food-choice-in-male-rats(d2a6da8f-882d-4323-a4e2-2b579852991b).html