Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jill Nunez"'
Johnson Science, Technology, Engineering, Art, and Mathematics (STEAM) Academy Magnet School (JSA) is a Magnet Schools of America Certified with Distinction Demonstration School located in Cedar Rapids, Iowa, in the USA. Embedding STEAM themes across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5de6f1c1e84ecde85332df6cde9e74
https://doi.org/10.14705/rpnet.2022.55.1359
https://doi.org/10.14705/rpnet.2022.55.1359
Autor:
Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
Publikováno v:
Journal of medicinal chemistry. 63(3)
Recent clinical evaluation of everolimus for seizure reduction in patients with tuberous sclerosis complex (TSC), a disease with overactivated mechanistic target of rapamycin (mTOR) signaling, has demonstrated the therapeutic value of mTOR inhibitors
Autor:
Yuji Mishina, Jianling Wang, Choi-Lai Tiong-Yip, He Guo, Noel Marie-France Thomsen, Jill Nunez, Franco Lombardo, Clayton Springer, Jason Baird, L. Alex Gaither, John D. Norris, Sunkyu Kim, Brant Firestone, Stefan Peukert, Kaitlin J. Macchi, Donald P. McDonnell, Tinya Abrams, Chunrong Wang, Bing Yu, Lawrence G. Hamann, Yingchuan Sun, Burks Heather Elizabeth, Christina A. Kirby, George Scott Tria
Publikováno v:
Journal of Medicinal Chemistry. 61:2837-2864
In breast cancer, estrogen receptor alpha (ERα) positive cancer accounts for approximately 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of ERα positive breast cancer has long relied on endocri
Autor:
Lili Xie, Charles R. Dean, Colin Osborne, Grazia Piizzi, Som Wattanasin, Jade Bojkovic, Francois Lenoir, Eugene Liu, Yipin Lu, Meir Glick, Donghui Yu, Tommasi Ruben A, Lawrence G. Hamann, Bing Wang, John Ryan Kerrigan, David Thomas Parker, Markus Dobler, Srijan Ranjitkar, JoAnn Dzink-Fox, Yunshan Peng, Leanne Lanieri, Hongming Wang, Xia Yang, David McKenney, Jill Nunez, Anup Patnaik, Maria-Dawn Lilly, Elizabeth R. Sprague
Publikováno v:
Journal of Medicinal Chemistry. 60:5002-5014
Over the past several decades, the frequency of antibacterial resistance in hospitals, including multidrug resistance (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cau
Autor:
Burks Heather Elizabeth, Noel Marie-France Thomsen, Alexander Fekete, Alice Loo, Christina A. Kirby, Lawrence G. Hamann, Yingchuan Sun, Chunrong Wang, Jianling Wang, Chitra Saran, Danuta Lubicka, Donald P. McDonnell, Yuji Mishina, Franco Lombardo, Jason Baird, Tinya Abrams, Kaitlin J. Macchi, Stefan Peukert, Jill Nunez, John D. Norris, Sunkyu Kim
Publikováno v:
Journal of medicinal chemistry. 60(7)
Tetrahydroisoquinoline 40 has been identified as a potent ERα antagonist and selective estrogen receptor degrader (SERD), exhibiting good oral bioavailability, antitumor efficacy, and SERD activity in vivo. We outline the discovery and chemical opti
Autor:
Richard Hughes, Guiqing Liang, Jeffrey Shapiro, Zhao Yan, Rishi K. Jain, Sarah J. Luchansky, Luis Llamas, Vidya Kunjathoor, Jill Nunez, Stefan Peukert, Michael Pietropaolo, Avirup Bose, Xiaoping Wu, Adam Carlson, Anja Castellana, Guo He
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1114-1118
The identification of highly potent and orally bioavailable GPR39 agonists is reported. Compound 1, found in a phenotypic screening campaign, was transformed into compound 2 with good activity on both the rat and human GPR39 receptor. This compound w
Autor:
Manus Ipek, Zhao-Kui Wan, Eva Binnun, Tarek S. Mansour, Jason Shaoyun Xiang, Seung Hahm, Xiangping Li, Huan-Qiu Li, James Tobin, Eddine Saiah, Vipin Suri, Yuzhe Xing, May Tam, Lihren Chen, John C. McKew, Jill Nunez, Xin Xu
Publikováno v:
Journal of Medicinal Chemistry. 51:4068-4071
11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is the enzyme that converts cortisone to cortisol. Evidence suggests that selective inhibition of 11beta-HSD1 could treat diabetes and metabolic syndrome. Presented herein are the synthesis, st
Publikováno v:
ChemInform. 43
Efficient methods to prepare various 5-arylated isoxazoles and 4-arylated triazoles are reported.
Publikováno v:
The Journal of organic chemistry. 76(12)
Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format,
Autor:
Megan A. Foley, William M. Abraham, Cheryl Nickerson-Nutter, John C. McKew, Xin Xu, Jill Nunez, Lihren Chen, Nevena Mollova, Weiheng Wang, Richard Vargas, Marina W.H. Shen, Manjunath K. Ramarao, Cara M. M. Williams, Tam Steve Yik-Kai, James D. Clark, Mark L. Behnke, Katherine L. Lee, Debra G. Goodwin
Publikováno v:
Bioorganicmedicinal chemistry. 16(3)
The synthesis and structure-activity relationship of a series of benzenesulfonamide indole inhibitors of cPLA(2)alpha are described. Substitution of the benzenesulfonamide led to analogues with 50-fold improvement in potency versus the unsubstituted