Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jill Miotke"'
Publikováno v:
Brain Research. 1613:13-26
A great deal of effort has been invested in using trophic factors and other bioactive molecules to promote cell survival and axonal regeneration in the adult central nervous system. Far less attention has been paid to investigating potential effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d4b9a931c2f18adbb276ccf43837f
https://doi.org/10.1016/j.brainres.2015.03.045
https://doi.org/10.1016/j.brainres.2015.03.045
Autor:
Jill Miotke, Joel M. Levine, Ronald L. Meyer, Ken-Ichi Takemaru, Michael Coulter, Justin P. Rodriguez
Publikováno v:
Journal of Neuroscience. 34:10285-10297
When the brain or spinal cord is injured, glial cells in the damaged area undergo complex morphological and physiological changes resulting in the formation of the glial scar. This scar contains reactive astrocytes, activated microglia, macrophages a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd92d6e94bd45dbb559b01b8250de6b
https://doi.org/10.1523/jneurosci.4915-13.2014
https://doi.org/10.1523/jneurosci.4915-13.2014
Autor:
Timo A. Nieminen, Halina Rubinsztein-Dunlop, Jill Miotke, Michael W. Berns, Tao Wu, Ronald L. Meyer, Samarendra K. Mohanty
Publikováno v:
Nature Photonics. 6:62-67
Axonal path-finding is important in the development of the nervous system, nerve repair and nerve regeneration. The behaviour of the growth cone at the tip of the growing axon determines the direction of axonal growth and migration. We have developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fcd81dbf268a8196e38896f0df669b2
https://doi.org/10.1038/nphoton.2011.287
https://doi.org/10.1038/nphoton.2011.287
Publikováno v:
The Journal of Comparative Neurology. 500:384-400
Ciliary neurotrophic factor (CNTF) is important for the survival and outgrowth of retinal ganglion cells (RGCs) in vitro. However, in vivo adult RGCs fail to regenerate and subsequently die following axotomy, even though there are high levels of CNTF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528bb88cfad605e9b737ff36b65b5261
https://doi.org/10.1002/cne.21174
https://doi.org/10.1002/cne.21174
Autor:
Michael W. Berns, Samarendra K. Mohanty, Timo A. Nieminen, Jill Miotke, Tao Wu, Ronald L. Meyer, Halina Rubinsztein-Dunlop
Publikováno v:
SPIE Proceedings.
We have combined a laser scissors and a laser tweezers to study, (1) the response of nerve fiber growth cones to laserinduced damage on single axons, and (2) localized microfluidic flow generated by laser-driven spinning birefringent particles. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f47e372928c3ec40a3dbbe771c4fcb2
https://doi.org/10.1117/12.930411
https://doi.org/10.1117/12.930411
Autor:
Tao Wu, Samarendra K. Mohanty, Linda Z. Shi, Lih-Huei L. Liaw, Michael W. Berns, Ronald L. Meyer, Veronica Gomez-Godinez, Jill Miotke
Publikováno v:
Wu, T; Mohanty, S; Gomez-Godinez, V; Shi, LZ; Liaw, LH; Miotke, J; et al.(2012). Neuronal growth cones respond to laser-induced axonal damage. Journal of the Royal Society Interface, 9(68), 535-547. doi: 10.1098/rsif.2011.0351. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2545r912
Although it is well known that damage to neurons results in release of substances that inhibit axonal growth, release of chemical signals from damaged axons that attract axon growth cones has not been observed. In this study, a 532 nm 12 ns laser was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0210db46ac5028d3cfd1fca0f872f9
http://www.escholarship.org/uc/item/2545r912
http://www.escholarship.org/uc/item/2545r912
Publikováno v:
SPIE Proceedings.
In this paper we induced sub-axotomy axonal damage and repair by use of the laser microbeam in cultured retinal ganglion cells. When growth cones are near the damaged site of an axon, some cases will respond to the damage by extending filopodia towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91a56aa9c5d90790c526be6bcc3d311b
https://doi.org/10.1117/12.907454
https://doi.org/10.1117/12.907454
Autor:
Ronald L. Meyer, Jill Miotke
Publikováno v:
Experimental Neurology. 107:214-221
One optic nerve of an adult mouse was crushed in the orbit. After 8 days, both retinas were explanted onto laminin-coated coverslips. Within 24 h, neurites grew out onto this substrate from explants with prior crush and by 48 h two-thirds of explants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e482137a7c333fdfc856f5663dddb4f6
https://doi.org/10.1016/0014-4886(90)90138-i
https://doi.org/10.1016/0014-4886(90)90138-i
Publikováno v:
Experimental neurology. 155(1)
This study asks if there might be irreversible maturational changes in adult neurons that limit their capacity to regenerate. Retina from adult and embryonic mouse were placed in culture on laminin substrates so that regenerating adult optic fibers c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5551ecbf99ab55c559e52af1bee48adf
https://pubmed.ncbi.nlm.nih.gov/9918712
https://pubmed.ncbi.nlm.nih.gov/9918712