Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jill M. Van Dalfsen"'
Autor:
David P. Nichols, Sarah J. Morgan, Michelle Skalland, Anh T. Vo, Jill M. Van Dalfsen, Sachinkumar B.P. Singh, Wendy Ni, Lucas R. Hoffman, Kailee McGeer, Sonya L. Heltshe, John P. Clancy, Steven M. Rowe, Peter Jorth, Pradeep K. Singh, the PROMISE-Micro Study Group
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 10 (2023)
Background Lung infections are among the most consequential manifestations of cystic fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs called CF transmembrane conductance regulator (CFTR) modulators improve act
Externí odkaz:
https://doaj.org/article/f38c402d2a6340749497b7d56e6094d6
Autor:
Joseph M. Pilewski, Eugene C. Nelson, Jill M. Van Dalfsen, George Z. Retsch-Bogart, Bonnie W. Ramsey, Cynthia George, Bruce C. Marshall, Christopher H. Goss
Publikováno v:
Journal of General Internal Medicine. 29:714-723
Bringing new therapies to patients with rare diseases depends in part on optimizing clinical trial conduct through efficient study start-up processes and rapid enrollment. Suboptimal execution of clinical trials in academic medical centers not only r
Autor:
Scott H. Donaldson, Tanja Gonska, Bonnie W. Ramsey, Scott D. Sagel, Umer Khan, Drucy Borowitz, Jill M. Van Dalfsen, Nicole Mayer-Hamblett, Steven M. Rowe, Daniel Gelfond, Elizabeth Joseloff, Sonya L. Heltshe
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 190:175-184
Rationale: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator recently approved for patients with CF age 6 and older with the G551D mutation. Objectives: To evaluate ivacaftor in a postapproval setting and determine
Publikováno v:
Journal of the Pediatric Infectious Diseases Society. 4:151-154
Chronic antibiotic suppression of cystic fibrosis (CF) infections has increased in the United States, as has isolation of Pseudomonas aeruginosa with reduced antibiotic susceptibility. However, analysis of the susceptibilities of 193 initial P aerugi
Autor:
Melissa A. Ashlock, Robert J. Beall, Preston W. Campbell, Bonnie W. Ramsey, Christopher M. Penland, Michael W. Konstan, Jill M. Van Dalfsen, Diana R. Wetmore, Nicole M. Hamblett
Publikováno v:
Seminars in Respiratory and Critical Care Medicine. 30:611-626
Therapeutics development for cystic fibrosis (CF) involves a coordinated effort among many groups, including individuals with CF and their caregivers, clinical research teams, and those in academia and industry who have discovered and developed the t
Publikováno v:
Journal of Clinical Microbiology. 40:2791-2794
The microscopic examination of Gram-stained sputum specimens is very helpful in the evaluation of patients with community-acquired pneumonia and has also been recommended for use in cystic fibrosis (CF) patients. This study was undertaken to evaluate
Publikováno v:
Journal of Clinical Microbiology. 40:26-30
A culture method utilizing quantitative plating on antibiotic-containing media has been proposed as a technique for the detection of tobramycin-resistant organisms that is more sensitive than standard methods. Typical sputum culture methods quantitat
How much doPseudomonas biofilms contribute to symptoms of pulmonary exacerbation in cystic fibrosis?
Publikováno v:
Pediatric Pulmonology. 39:504-506
Recent studies suggest that chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) involve anaerobic biofilms, and that these biofilms are the reason chronic infections are rarely eradicated by antibiotic therapy, regardless of the in
Autor:
Jonathan Ilowite, Heather Tully, Alan F. Barker, Leslie Couch, Jack O. Stewart, Anne O'Donnell, Tammy Abuan, Stanley B. Fiel, Lewis J. Smith, Steven A. Sahn, Jill M. Van Dalfsen, Mark H. Gotfried, Joanne Quan, Keith C. Meyer, Charles D. Wells
Publikováno v:
American journal of respiratory and critical care medicine. 162(2 Pt 1)
We conducted a placebo-controlled, double-blind, randomized study to evaluate the microbiological efficacy and safety of inhaled tobramycin for treatment of patients with bronchiectasis and Pseudomonas aeruginosa. Patients were randomly assigned to r
Autor:
Richard L. Garber, Joanne M. Quan, Kelly L. Otto, Bonnie W. Ramsey, Jane L. Burns, Arnold L. Smith, A. Bruce Montgomery, Gary M. Albers, Jill M. Van Dalfsen, Ribhi M. Shawar
Publikováno v:
The Journal of infectious diseases. 179(5)
Pseudomonas aeruginosa endobronchial infection causes significant morbidity and mortality among cystic fibrosis patients. Microbiology results from two multicenter, double-blind, placebo-controlled trials of inhaled tobramycin in cystic fibrosis were