Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jill M. Brown"'
Autor:
Julia Truch, Damien J. Downes, Caroline Scott, E. Ravza Gür, Jelena M. Telenius, Emmanouela Repapi, Ron Schwessinger, Matthew Gosden, Jill M. Brown, Stephen Taylor, Pak Leng Cheong, Jim R. Hughes, Douglas R. Higgs, Richard J. Gibbons
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The chromatin remodeling complex ATRX can promote gene expression, for example by binding G-quadruplexes (G4s) to prevent their negative effect on expression. Here the authors use a single-cell approach to show that only a subset of erythroid cells i
Externí odkaz:
https://doaj.org/article/129ba3790d2848caac330a7a88d251ec
Autor:
Caroline Scott, Damien J. Downes, Jill M. Brown, Robert Beagrie, Aude-Anais Olijnik, Matthew Gosden, Ron Schwessinger, Christopher A. Fisher, Anna Rose, David J.P Ferguson, Errin Johnson, Quentin A. Hill, Steven Okoli, Raffaele Renella, Kate Ryan, Marjorie Brand, Jim Hughes, Noemi B.A. Roy, Douglas R. Higgs, Christian Babbs, Veronica J. Buckle
Publikováno v:
Haematologica, Vol 106, Iss 11 (2020)
The investigation of inherited disorders of erythropoiesis has elucidated many of the principles underlying the production of normal red blood cells and how this is perturbed in human disease. Congenital dyserythropoietic anemia type 1 (CDA-I) is a r
Externí odkaz:
https://doaj.org/article/0fcc0bfec45f409db5985ffd8cff4142
Autor:
James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose
Publikováno v:
Cell Reports, Vol 30, Iss 3, Pp 820-835.e10 (2020)
Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression.
Externí odkaz:
https://doaj.org/article/04343456c33648c2bdd2312d131af175
Autor:
Jill M. Brown, Nigel A. Roberts, Bryony Graham, Dominic Waithe, Christoffer Lagerholm, Jelena M. Telenius, Sara De Ornellas, A. Marieke Oudelaar, Caroline Scott, Izabela Szczerbal, Christian Babbs, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs, Veronica J. Buckle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb domain that includes the mouse α-globin regulato
Externí odkaz:
https://doaj.org/article/330016a401574168bf45d1576eed899f
Publikováno v:
Nature Protocols. 17:1306-1331
DNA fluorescence in situ hybridization (FISH) has been a central technique in advancing our understanding of how chromatin is organized within the nucleus. With the increasing resolution offered by super-resolution microscopy, the optimal maintenance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97652bf86b6f1525a6f7dce64166f119
https://doi.org/10.1038/s41596-022-00685-8
https://doi.org/10.1038/s41596-022-00685-8
Autor:
Stephen C. Hyde, Julian C. Knight, Fadi Issa, Amy Cross, Damien J. Downes, S N Sansom, Nigel A. Roberts, Peng Hua, Ron Schwessinger, Olga Mielczarek, C. De Andrea, Davies Joj., Altar M. Munis, Antony J. Cutler, Jim R. Hughes, Deborah R. Gill, Ignacio Melero, Jill M. Brown, John A. Todd
Publikováno v:
Nature Genetics. 53:1606-1615
The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) disease (COVID-19) pandemic has caused millions of deaths worldwide. Genome-wide association studies identified the 3p21.31 region as conferring a twofold increased risk of respirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa7deb797423fb5831e970856ffba02
https://doi.org/10.1038/s41588-021-00955-3
https://doi.org/10.1038/s41588-021-00955-3
Autor:
Jacqueline A. Sharpe, D.M. Jeziorska, B. Christoffer Lagerholm, Doug Higgs, Andrew J.H. Smith, Veronica J. Buckle, Jill M. Brown, Jacqueline A. Sloane-Stanley, Edward Tunnacliffe, Helena Ayyub, Christian Babbs
Determining the mechanisms by which genes are switched on and off during development and differentiation is a key aim of current biomedical research. Gene transcription has been widely observed to occur in a discontinuous fashion, with short bursts o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e4db11b1abd57f4db562bf24fd3a0d
https://doi.org/10.1101/2021.11.26.470114
https://doi.org/10.1101/2021.11.26.470114
Autor:
Ron Schwessinger, N Roy, Anna M. Rose, Chris Fisher, Raffaele Renella, Jill M. Brown, Kate Ryan, Jim R. Hughes, Veronica J. Buckle, Damien J. Downes, Quentin A. Hill, David J. P. Ferguson, Errin Johnson, Douglas R. Higgs, Aude-Anais Olijnik, M Gosden, Steven Okoli, Robert A. Beagrie, Marjorie Brand, Caroline Scott, Christian Babbs
Publikováno v:
Haematologica
Haematologica, vol. 106, no. 11, pp. 2960-2970
Haematologica, vol. 106, no. 11, pp. 2960-2970
The investigation of inherited disorders of erythropoiesis has elucidated many of the principles underlying the production of normal red blood cells and how this is perturbed in human disease. Congenital dyserythropoietic anemia type 1 (CDA-I) is a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a8f19d6ee934982846efd9e4847a92
https://pubmed.ncbi.nlm.nih.gov/33121234
https://pubmed.ncbi.nlm.nih.gov/33121234
Autor:
Cassandravictoria Innocent, Veronica J. Buckle, Lothar Schermelleh, A. R. Carvalho Faria, Ezequiel Miron, Haitham A. Shaban, Roel Oldenkamp, David Miguel Susano Pinto, S de Ornellas, Jill M. Brown, James D.P. Rhodes
Publikováno v:
Science Advances
Advanced FIB-SEM and 3D-SIM imaging uncover cohesin-independent chromatin arrangement into structural and functional modules.
Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian genome function; however, many o
Three-dimensional (3D) chromatin organization plays a key role in regulating mammalian genome function; however, many o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20673d194b322ae4288e38151614bcaf
Autor:
Eva-Lena Maria Stattin, Christian Babbs, Johan Mäkk, Sanja Brolih, Caroline Scott, Damien J. Downes, Aude-Anais Olijnik, Melanie Proven, Kate Ryan, Douglas R. Higgs, Raffaele Renella, Quentin A. Hill, Anja Groth, Jill M. Brown, Katrine Ask, Nandini Sadasivam, Louisa McIlwaine, Ria Hipkiss, Veronica J. Buckle, Jim R. Hughes, Joseph A. Marsh, Noémi B. A. Roy, Per Frisk, Barbara Xella, Peter J. McHugh, Richard J. Gibbons, Errin Johnson, Karin Lauschke, Nigel A. Roberts
Publikováno v:
Olijnik, A-A, Roy, N B A, Scott, C, Marsh, J A, Brown, J, Lauschke, K, Ask, K, Roberts, N, Downes, D J, Brolih, S, Johnson, E, Xella, B, Proven, M, Hipkiss, R, Ryan, K, Frisk, P, Mäkk, J, Stattin, E-L M, Sadasivam, N, McIlwaine, L, Hill, Q A, Renella, R, Hughes, J R, Gibbons, R J, Groth, A, McHugh, P J, Higgs, D R, Buckle, V J & Babbs, C 2020, ' Genetic and functional insights into CDA-I prevalence and pathogenesis ', Journal of Medical Genetics, vol. 58, pp. 185-195 . https://doi.org/10.1136/jmedgenet-2020-106880
J Med Genet
Olijnik, A A, Roy, N B A, Scott, C, Marsh, J A, Brown, J, Lauschke, K, Ask, K, Roberts, N, Downes, D J, Brolih, S, Johnson, E, Xella, B, Proven, M, Hipkiss, R, Ryan, K, Frisk, P, Mäkk, J, Stattin, E L M, Sadasivam, N, McIlwaine, L, Hill, Q A, Renella, R, Hughes, J R, Gibbons, R J, Groth, A, McHugh, P J, Higgs, D R, Buckle, V J & Babbs, C 2021, ' Genetic and functional insights into CDA-I prevalence and pathogenesis ', Journal of Medical Genetics, vol. 58, pp. 185-195 . https://doi.org/10.1136/jmedgenet-2020-106880
Olijnik, A-A, Roy, N, Scott, C, Marsh, J, Lauschke, K, Ask, K, Roberts, N, Downes, D J, Brown, J, Brolih, S, Johnson, E, Xella, B, Proven, M, Hipkiss, R, Ryan, K, Frisk, P, Makk, J, Stattin, E, Sadasivam, N, McIlwaine, L, Hill, Q A, Renella, R, Hughes, J R, Gibbons, R, Groth, A, McHugh, P J, Higgs, D R, Buckle, V J & Babbs, C 2020, ' Genetic and Functional Insights into CDA-I Prevalence and Pathogenesis ', Journal of Medical Genetics . https://doi.org/10.1136/jmedgenet-2020-106880
J Med Genet
Olijnik, A A, Roy, N B A, Scott, C, Marsh, J A, Brown, J, Lauschke, K, Ask, K, Roberts, N, Downes, D J, Brolih, S, Johnson, E, Xella, B, Proven, M, Hipkiss, R, Ryan, K, Frisk, P, Mäkk, J, Stattin, E L M, Sadasivam, N, McIlwaine, L, Hill, Q A, Renella, R, Hughes, J R, Gibbons, R J, Groth, A, McHugh, P J, Higgs, D R, Buckle, V J & Babbs, C 2021, ' Genetic and functional insights into CDA-I prevalence and pathogenesis ', Journal of Medical Genetics, vol. 58, pp. 185-195 . https://doi.org/10.1136/jmedgenet-2020-106880
Olijnik, A-A, Roy, N, Scott, C, Marsh, J, Lauschke, K, Ask, K, Roberts, N, Downes, D J, Brown, J, Brolih, S, Johnson, E, Xella, B, Proven, M, Hipkiss, R, Ryan, K, Frisk, P, Makk, J, Stattin, E, Sadasivam, N, McIlwaine, L, Hill, Q A, Renella, R, Hughes, J R, Gibbons, R, Groth, A, McHugh, P J, Higgs, D R, Buckle, V J & Babbs, C 2020, ' Genetic and Functional Insights into CDA-I Prevalence and Pathogenesis ', Journal of Medical Genetics . https://doi.org/10.1136/jmedgenet-2020-106880
BackgroundCongenital dyserythropoietic anaemia type I (CDA-I) is a hereditary anaemia caused by biallelic mutations in the widely expressed genes CDAN1 and C15orf41. Little is understood about either protein and it is unclear in which cellular pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028e96328f2aa1322c6bd5ccd97632f9
https://curis.ku.dk/ws/files/290041631/Genetic_and_functional_insights_into_CDA_I_prevalence_and_pathogenesis_proof_version_.pdf
https://curis.ku.dk/ws/files/290041631/Genetic_and_functional_insights_into_CDA_I_prevalence_and_pathogenesis_proof_version_.pdf