Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase

Autor: Zhongliang Jiang, Yanhao Lai, Jill M. Beaver, Pawlos S. Tsegay, Ming-Lang Zhao, Julie K. Horton, Marco Zamora, Hayley L. Rein, Frank Miralles, Mohammad Shaver, Joshua D. Hutcheson, Irina Agoulnik, Samuel H. Wilson, Yuan Liu

Publikováno v: Cells, Vol 9, Iss 1, p 225 (2020)

DNA damage and base excision repair (BER) are actively involved in the modulation of DNA methylation and demethylation. However, the underlying molecular mechanisms remain unclear. In this study, we seek to understand the mechanisms by exploring the

Externí odkaz: https://doaj.org/article/788c11cb8b9c443193a8998431ba13e9

The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium

Autor: James M. Anderson, Frederick L. Tyson, Linda S. Birnbaum, Lisa H. Chadwick, John S. Satterlee, Kim McAllister, Ananda L. Roy, Elizabeth L. Wilder, Nora D. Volkow, Jill M. Beaver

Publikováno v: Science Advances

We outline the reasons why the Roadmap Epigenomics Program, as a group science effort, is a success story.
The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc3febcb2cd85ac105f75510d33cec3
https://pubmed.ncbi.nlm.nih.gov/31501771

AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair

Autor: Eduardo E. Laverde, Meng Xu, Jill M. Beaver, Yuan Liu, Astrid H. Casin, Yanhao Lai

Publikováno v: Nucleic Acids Research

Base excision repair (BER) of an oxidized base within a trinucleotide repeat (TNR) tract can lead to TNR expansions that are associated with over 40 human neurodegenerative diseases. This occurs as a result of DNA secondary structures such as hairpin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1974329d5abe8d070ecf93fa1f5f3210
https://doi.org/10.1093/nar/gkv530

An oxidized abasic lesion inhibits base excision repair leading to DNA strand breaks in a trinucleotide repeat tract

Autor: Yuan Liu, Yanhao Lai, Shantell J. Rolle, Jill M. Beaver, Liwei Weng, Marc M. Greenberg

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 2, p e0192148 (2018)

Oxidative DNA damage and base excision repair (BER) play important roles in modulating trinucleotide repeat (TNR) instability that is associated with human neurodegenerative diseases and cancer. We have reported that BER of base lesions can lead to T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ac4a50ce0db7c3060dc09fb4df865c
https://pubmed.ncbi.nlm.nih.gov/29389977

Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair

Autor: Yuan Liu, Cynthia T. McMurray, Zunzhen Zhang, Helen Budworth, Jill M. Beaver, Yanhao Lai, Nelson L. S. Chan

Publikováno v: Nature communications, vol 7, iss 1
Lai, Y; Budworth, H; Beaver, JM; Chan, NLS; Zhang, Z; McMurray, CT; et al.(2016). Crosstalk between MSH2-MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair. Nature Communications, 7. doi: 10.1038/ncomms12465. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/12b1d15v
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

Studies in knockout mice provide evidence that MSH2–MSH3 and the BER machinery promote trinucleotide repeat (TNR) expansion, yet how these two different repair pathways cause the mutation is unknown. Here we report the first molecular crosstalk mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d1dd56333dcf012e740a54adda0cef
https://escholarship.org/uc/item/12b1d15v