Myelin Dynamics Throughout Life: An Ever-Changing Landscape?

Autor: Jill M. Williamson, David A. Lyons

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Myelin sheaths speed up impulse propagation along the axons of neurons without the need for increasing axon diameter. Subsequently, myelin (which is made by oligodendrocytes in the central nervous system) allows for highly complex yet compact circuit

Externí odkaz: https://doaj.org/article/7ad8f582845c4a28a4829ae033323021

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective

Autor: Robert Swingler, Nigel Leigh, Christine Weaver, Nigel Stallard, Amina Chaouch, Dawn Lyle, Francisco Javier Carod-Artal, Suvankar Pal, Richard A Parker, Ian Morrison, Hisham Hamdalla, Amy Stenson, Pablo Garcia Reitboeck, Jenny Preston, Venkataramanan Srinivasan, Ashwin Pinto, Judith Newton, Stella A. Glasmacher, Arpan R Mehta, Rachel Dakin, Callum Duncan, Aleksandar Radunovic, Siddharthan Chandran, Richard Davenport, Jeremy Chataway, Elizabeth Elliott, Maria Stavrou, John Ealing, Tim Williams, Jenna M. Gregory, George Gorrie, Mahesh K. B. Parmar, Charis Wong, Emily Beswick, Jill M Williamson, Danielle Leighton, Christopher J. Weir, Malcolm R. Macleod, Peter J. Connelly

Publikováno v: Brain Communications
Wong, C, Stavrou, M, Elliott, L, Gregory, J, Leigh, P N, Pinto, A, Williams, T, Chataway, J, Swingler, R, Parmar, M K B, Stallard, N, Weir, C J, Parker, R A, Chaouch, A, Hamdalla, H, Ealing, J, Gorrie, G, Morrison, I, Duncan, C, Connelly, P, Javier Carod-Artal, F, Davenport, R, Reitboeck, P G, Radunovic, A, Srinivasan, V, Preston, J, Mehta, A, Leighton, D, Glasmacher, S, Beswick, E, Williamson, J, Stenson, A, Weaver, C, Newton, J, Lyle, D, Dakin, R S, MacLeod, M, Pal, S & Chandran, S 2021, ' Clinical trials in amyotrophic lateral sclerosis : a systematic review and perspective ', Brain Communications, vol. 3, no. 4 . https://doi.org/10.1093/braincomms/fcab242, https://doi.org/10.1093/braincomms/fcab242

Amyotrophic lateral sclerosis is a progressive and devastating neurodegenerative disease. Despite decades of clinical trials, effective disease-modifying drugs remain scarce. To understand the challenges of trial design and delivery, we performed a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91afba6db5d18614e79af23fbeb9ff09
https://pubmed.ncbi.nlm.nih.gov/34901853

Synaptic vesicle fusion along axons is driven by myelination and subsequently accelerates sheath growth in an activity-regulated manner

Autor: Jill M Williamson, Isaac H. Bianco, Megan E Madden, Matthew G. Voas, Rafael G. Almeida, William S. Talbot, David A. Lyons, Jason J Early

To study activity-regulated myelination, we imaged synaptic vesicle fusion along single axons in living zebrafish, and found, surprisingly, that axonal synaptic vesicle fusion is driven by myelination. This myelin-induced axonal vesicle fusion was en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1d11a925fd5e1d9676fe4513fed9700
https://doi.org/10.1101/2020.08.28.271593

Manipulating Neuronal Activity in the Developing Zebrafish Spinal Cord to Investigate Adaptive Myelination

Autor: Jill M, Williamson, David A, Lyons, Rafael G, Almeida

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1936

In the central nervous system, oligodendrocyte-lineage cells and myelination can adapt to physiological brain activity. Since myelin can in turn regulate neuronal function, such "adaptive" myelination has been proposed as a form of nervous system pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2e37c23bc615c9cdb2ea73043f1734d
https://pubmed.ncbi.nlm.nih.gov/30820901

Myelin Dynamics Throughout Life: An Ever-Changing Landscape?

Autor: David A. Lyons, Jill M Williamson

Publikováno v: Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Williamson, J M & Lyons, D A 2018, ' Myelin Dynamics Throughout Life : An Ever-Changing Landscape? ', Frontiers in Cellular Neuroscience, vol. 12, pp. 424 . https://doi.org/10.3389/fncel.2018.00424

Myelin sheaths speed up impulse propagation along the axons of neurons without the need for increasing axon diameter. Subsequently, myelin (which is made by oligodendrocytes in the central nervous system) allows for highly complex yet compact circuit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd2ee5ce895afdb96b5a8813dd556a3
https://doi.org/10.3389/fncel.2018.00424