Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jill M Grenier"'
Autor:
Christopher M Owens, Christina Mawhinney, Jill M Grenier, Ralf Altmeyer, Margaret S Lee, Alexis A Borisy, Joseph Lehár, Lisa M Johansen
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
The search for effective Hepatitis C antiviral therapies has recently focused on host sterol metabolism and protein prenylation pathways that indirectly affect viral replication. However, inhibition of the sterol pathway with statin drugs has not yie
Externí odkaz:
https://doaj.org/article/b4b9b49657b3440dabf153426b420ffc
Autor:
Gene G. Olinger, Judith M. White, Lisa M. Johansen, Pamela J. Glass, Jill M. Grenier, Elizabeth A. Nelson, Charles J. Shoemaker, Calli M. Lear-Rooney, Laura T. Pierce, Lisa Evans DeWald, Andrea Stossel, James A. Simmons, Hassan Pajouhesh, Sue E. Delos, Benjamin G. Hoffstrom, Lisa E. Hensley, Joseph Lehar
Publikováno v:
Science translational medicine. 7(290)
Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a
DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
Autor:
Sandeep Robert Datta, Michael E. Greenberg, Jill M. Grenier, Anne Brunet, Albert J. Fornace, Lillian W. Chiang, Hien Tran, Peter S. DiStefano
Publikováno v:
Science. 296:530-534
The signaling pathway from phosphoinositide 3-kinase to the protein kinase Akt controls organismal life-span in invertebrates and cell survival and proliferation in mammals by inhibiting the activity of members of the FOXO family of transcription fac
Autor:
Jill M. Grenier, Peter S. DiStefano, Lorayne Jenkins, Fenyu Jin, Andrew R. Wood, Laurence Ettwiller, Lillian W. Chiang, Dave Ficenec, John D. Martin
Publikováno v:
Proceedings of the National Academy of Sciences. 98:2814-2819
Programmed cell death (PCD) during neuronal development and disease has been shown to require de novo RNA synthesis. However, the time course and regulation of target genes is poorly understood. By using a brain-biased array of over 7,500 cDNAs, we p
Autor:
Ralf Altmeyer, Alexis Borisy, Christopher M. Owens, Margaret S. Lee, Joseph Lehar, Christina Mawhinney, Lisa M. Johansen, Jill M. Grenier
Publikováno v:
Molecular Systems Biology
SREBP-2, oxidosqualene cyclase (OSC) or lanosterol demethylase were identified as novel sterol pathway-associated targets that, when probed with chemical agents, can inhibit hepatitis C virus (HCV) replication. Using a combination chemical genetics a
Autor:
Karen McGovern, Kerrie Faia, Jeffrey L. Kutok, Jennifer L. Proctor, Andrew J. Souers, Vito J. Palombella, Richard Rickles, Jill M. Grenier, Paula Andrade, Erwin R. Boghaert, Kerry White, Melissa Pink, Joel D. Leverson
Publikováno v:
Journal of Clinical Oncology. 33:8559-8559
8559 Background: Signaling via PI3K-δ and PI3K-γ has distinct and complementary effects on the tumor cell/ tumor microenvironment in hematologic malignancies (HM). Duvelisib (IPI-145) is an orally active inhibitor of the PI3K-δ and PI3K-γ isoform
Autor:
Jeffrey D. Kennedy, Jill M. Grenier, Nivedita Ghosh, Bradley A. Ozenberger, Brendan Bingham, Lillian W. Chiang, Ru Shen, Andrew Wood, Smita Kotnis, Peter S. DiStefano, J. Steven Jacobsen, C. Frederick Lo
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 69(11)
Background NARC 1/PCSK9 encodes a novel serine proteinase known to play a role in cholesterol homeostasis. NARC 1 mRNA expression in cerebellar granule neurons (CGNs) was discovered to be induced following an apoptotic injury. Coregulation of known a
Autor:
Ying Huang, Jeffrey D. Kennedy, Bradley A. Ozenberger, J. Steven Jacobsen, Brendan Bingham, Jill M. Grenier, Peter S. DiStefano, Saule Naureckiene, Kodangattil Sreekumar, C. Frederick Lo, Urmila Purandare, Andrew Wood, Lillian W. Chiang, Linh Ma
Publikováno v:
Archives of biochemistry and biophysics. 420(1)
The NARC 1 gene encodes a novel proteinase K family proteinase. The domain structure of rat Narc 1 resembles that of the subtilisin-like proprotein convertases (SPCs), except that rNarc 1 lacks the canonical P-domain of SPCs, retaining only the RGD m
Publikováno v:
ChemInform. 34
Autor:
Jill M. Grenier, Jose M. Lora, Amal Al-Garawi, John Bertin, Peter S. DiStefano, Brad J. Geddes, Lin Wang, Sarah Merriam, Gulam A. Manji, Michael J. Briskin
Publikováno v:
The Journal of biological chemistry. 277(33)
PYRIN-containing Apaf1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of signal transduction proteins. We report here that PYPAF7 is a novel PYPAF protein that activates inflammatory signaling p