Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jill M Dowen"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009435 (2021)
The cohesin complex spatially organizes interphase chromatin by bringing distal genomic loci into close physical proximity, looping out the intervening DNA. Mutation of cohesin complex subunits is observed in cancer and developmental disorders, but t
Externí odkaz:
https://doaj.org/article/74bd8bc1527a43c6862d1be5e8260b8a
Autor:
Aki K. Braceros, Megan D. Schertzer, Arina Omer, Jackson B. Trotman, Eric S. Davis, Jill M. Dowen, Douglas H. Phanstiel, Erez Lieberman Aiden, J. Mauro Calabrese
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112803- (2023)
Summary: During mouse embryogenesis, expression of the long non-coding RNA (lncRNA) Airn leads to gene repression and recruitment of Polycomb repressive complexes (PRCs) to varying extents over a 15-Mb domain. The mechanisms remain unclear. Using hig
Externí odkaz:
https://doaj.org/article/a662b708f3d1487695b89dec71f24f05
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization. Ho
Externí odkaz:
https://doaj.org/article/a35eeecd837c4d9cbac7861d46e725af
Autor:
Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan, Jill M. Dowen
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-17 (2020)
Abstract Background The three-dimensional organization of the genome in the nucleus plays an integral role in many biological processes, including gene expression. The genome is folded into DNA loops that bring together distal regulatory elements and
Externí odkaz:
https://doaj.org/article/aec3e4ceb64740acba5b0e7b18750172
Autor:
Aki K. Braceros, Megan D. Schertzer, Arina Omer, Jackson B. Trotman, Eric S. Davis, Jill M. Dowen, Douglas H. Phanstiel, Erez Lieberman Aiden, J. Mauro Calabrese
During mouse embryogenesis, expression of the lncRNAAirninduces gene silencing and recruits Polycomb Repressive Complexes (PRCs) to varying extents over a 15 megabase domain. The mechanisms remain unclear. Using high-resolution approaches, we show in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9add6ef8dc88740d5119616159e78ca
https://doi.org/10.1101/2022.12.20.521198
https://doi.org/10.1101/2022.12.20.521198
Publikováno v:
Epigenetics & Chromatin. 15
Background Cohesin is an important structural regulator of the genome, regulating both three-dimensional genome organization and gene expression. The core cohesin trimer interacts with various HEAT repeat accessory subunits, yielding cohesin complexe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27737bc913e0b2a267694bcacfc78232
https://doi.org/10.1186/s13072-022-00463-6
https://doi.org/10.1186/s13072-022-00463-6
Autor:
Holden C. Stefan, Junjie Zhou, Nicole L Arruda, Ying Frances Liu, Jill M. Dowen, Zachary M. Carico, Megan Justice
Publikováno v:
Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-17 (2020)
Epigenetics & Chromatin
Epigenetics & Chromatin
Background The three-dimensional organization of the genome in the nucleus plays an integral role in many biological processes, including gene expression. The genome is folded into DNA loops that bring together distal regulatory elements and genes. C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1c611805b2d06f7b3fdb0aff9d82a4
http://link.springer.com/article/10.1186/s13072-020-00353-9
http://link.springer.com/article/10.1186/s13072-020-00353-9
Publikováno v:
Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17045d876ba567ac66c958a2c05144e0
https://doi.org/10.1016/j.ymeth.2019.06.002
https://doi.org/10.1016/j.ymeth.2019.06.002
Publikováno v:
BMC genomics. 23(1)
Background The cohesin complex is essential for proper chromosome structure and gene expression. Defects in cohesin subunits and regulators cause changes in cohesin complex dynamics and thereby alter three-dimensional genome organization. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0214642f8c81f64f0dc186d56a08f23
https://pubmed.ncbi.nlm.nih.gov/35501690
https://pubmed.ncbi.nlm.nih.gov/35501690
Autor:
Junjie Zhou, Natalie L Rittenhouse, Zachary M. Carico, Ying Frances Liu, Jill M. Dowen, Nicole L Arruda, Holden C. Stefan
Publikováno v:
Genetics
Cohesin is a ring-shaped protein complex that controls dynamic chromosome structure. Cohesin activity is important for a variety of biological processes, including formation of DNA loops that regulate gene expression. The precise mechanisms by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0111e042ce2d3ac53c01947a3fd0728
https://pubmed.ncbi.nlm.nih.gov/33704438
https://pubmed.ncbi.nlm.nih.gov/33704438