Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Jill L. Thompson"'
Publikováno v:
The Journal of Physiology. 593:559-572
Key points Although both the calcium store-dependent CRAC channels and the store-independent ARC channels are regulated by the protein STIM1, CRAC channels are regulated by STIM1 in the endoplasmic reticulum, whilst ARC channels are regulated by the
Autor:
Mark Duquette, Jack Lawler, Monica J. S. Nadler, Trevor J. Shuttleworth, Dayne Okuhara, Jill L. Thompson
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology
The thrombospondins (TSPs) are a family of matricellular proteins that regulate cellular phenotype through interactions with a myriad of other proteins and proteoglycans. We have identified a novel interaction of the members of the TSP gene family wi
Publikováno v:
Channels. 7:364-373
The discovery of the Orai proteins, and the identification of STIM1 as the molecule that regulates them, was based on their role in the agonist-activated store-operated entry of calcium via the CRAC channels. However, these same proteins are also ess
Publikováno v:
The Journal of Physiology. 591:3507-3523
Currently, Orai proteins are known to encode two distinct agonist-activated, highly calcium-selective channels: the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels, and the store-independent, arachidonic acid-activated ARC channels. Su
Publikováno v:
Channels
The Orai family of calcium channels includes the store-operated CRAC channels and store-independent, arachidonic acid (AA)-regulated ARC channels. Both depend on STIM1 for their activation but, whereas CRAC channel activation involves sensing the dep
Publikováno v:
The Journal of Physiology. 589:5057-5069
The frequency of oscillatory Ca(2+) signals is a major determinant in the selective activation of discrete downstream responses in non-excitable cells. An important modulator of this oscillation frequency is known to be the rate of agonist-activated
Autor:
Trever J. Shuttleworth, Peter B. Stathopulos, Yue Lai-Zhao, Jill L. Thompson, Alan Grossfield
Publikováno v:
Journal of Biological Chemistry. 293:11241
Low-conductance, highly calcium-selective channels formed by the Orai proteins exist as store-operated CRAC channels and store-independent, arachidonic acid–activated ARC channels. Both are activated by stromal interaction molecule 1 (STIM1), but C
Publikováno v:
The Journal of Physiology. 587:4181-4197
The activation of Ca2+ entry is a critical component of agonist-induced cytosolic Ca2+ signals in non-excitable cells. Although a variety of different channels may be involved in such entry, the recent identification of the STIM and Orai proteins has
Publikováno v:
The Journal of Physiology. 586:419-425
Agonist-activated Ca2+ entry plays a critical role in Ca2+ signalling in non-excitable cells. One mode of such entry is activated as a consequence of the depletion of intracellular Ca2+ stores. This depletion is sensed by the protein STIM1 in the end
Publikováno v:
The Journal of Physiology. 586:185-195
Agonist-activated Ca2+ signals in non-excitable cells are profoundly influenced by calcium entry via both store-operated and store-independent conductances. Recent studies have demonstrated that STIM1 plays a key role in the activation of store-opera