Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Jill L. Silverman"'
Autor:
Lyndsey L. Anderson, Declan Everett‐Morgan, Stela P. Petkova, Jill L. Silverman, Jonathon C. Arnold
Publikováno v:
Epilepsia Open, Vol 8, Iss 3, Pp 776-784 (2023)
Abstract Objective Ictal vocalizations have shown diagnostic utility in epilepsy patients. Audio recordings of seizures have also been used for seizure detection. The present study aimed to determine whether generalized tonic–clonic seizures in the
Externí odkaz:
https://doaj.org/article/3b46039d8e3f4a42952067a969b9cd7f
Autor:
Ulrika Beitnere, Brayan Vilanova-Cuevas, Sarah G. Christian, Clint Taylor, Elizabeth L. Berg, Nycole A. Copping, Scott V. Dindot, Jill L. Silverman, Mélanie G. Gareau, David J. Segal
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT A large subset of patients with Angelman syndrome (AS) suffer from concurrent gastrointestinal (GI) issues, including constipation, poor feeding, and reflux. AS is caused by the loss of ubiquitin ligase E3A (UBE3A) gene expression in the bra
Externí odkaz:
https://doaj.org/article/603c826aee6f48c298a9ce88f28aaa34
Autor:
Elizabeth L. Berg, Stela P. Petkova, Heather A. Born, Anna Adhikari, Anne E. Anderson, Jill L. Silverman
Publikováno v:
Molecular Autism, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Angelman Syndrome (AS) is a rare neurodevelopmental disorder for which there is currently no cure or effective therapeutic. Since the genetic cause of AS is known to be dysfunctional expression of the maternal allele of ubiquitin
Externí odkaz:
https://doaj.org/article/248aa6f6f0a749df873e2e42f60659e7
Autor:
Jessica L. Haigh, Anna Adhikari, Nycole A. Copping, Tyler Stradleigh, A. Ayanna Wade, Rinaldo Catta-Preta, Linda Su-Feher, Iva Zdilar, Sarah Morse, Timothy A. Fenton, Anh Nguyen, Diana Quintero, Samrawit Agezew, Michael Sramek, Ellie J. Kreun, Jasmine Carter, Andrea Gompers, Jason T. Lambert, Cesar P. Canales, Len A. Pennacchio, Axel Visel, Diane E. Dickel, Jill L. Silverman, Alex S. Nord
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
Abstract Background Genes with multiple co-active promoters appear common in brain, yet little is known about functional requirements for these potentially redundant genomic regulatory elements. SCN1A, which encodes the NaV1.1 sodium channel alpha su
Externí odkaz:
https://doaj.org/article/78fe0a2d5b104a109781adedaf6df4e5
Autor:
Eduardo A. González, Jonas J. Calsbeek, Yi-Hua Tsai, Mei-Yun Tang, Peter Andrew, Joan Vu, Elizabeth L. Berg, Naomi H. Saito, Danielle J. Harvey, Suangsuda Supasai, Gene G. Gurkoff, Jill L. Silverman, Pamela J. Lein
Publikováno v:
Current Research in Toxicology, Vol 2, Iss , Pp 341-356 (2021)
Preclinical efforts to improve medical countermeasures against organophosphate (OP) chemical threat agents have largely focused on adult male models. However, age and sex have been shown to influence the neurotoxicity of repeated low-level OP exposur
Externí odkaz:
https://doaj.org/article/22f608d09350421494ce98bb95f80fc0
Autor:
Elizabeth L. Berg, Tianna M. Ching, Donald A. Bruun, Josef K. Rivera, Milo Careaga, Jacob Ellegood, Jason P. Lerch, Markus Wöhr, Pamela J. Lein, Jill L. Silverman
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 12, Iss 1, Pp 1-15 (2020)
Abstract Background Neurodevelopmental disorders (NDDs), including intellectual disability, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), are pervasive, lifelong disorders for which pharmacological interventions
Externí odkaz:
https://doaj.org/article/740a18ca2df0470a99cf6e1fbaa83ca8
Autor:
Peter Deng, Julian A. N. M. Halmai, Ulrika Beitnere, David Cameron, Michele L. Martinez, Charles C. Lee, Jennifer J. Waldo, Krista Thongphanh, Anna Adhikari, Nycole Copping, Stela P. Petkova, Ruth D. Lee, Samantha Lock, Miranda Palomares, Henriette O’Geen, Jasmine Carter, Casiana E. Gonzalez, Fiona K. B. Buchanan, Johnathan D. Anderson, Fernando A. Fierro, Jan A. Nolta, Alice F. Tarantal, Jill L. Silverman, David J. Segal, Kyle D. Fink
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Zinc finger (ZF), transcription activator-like effectors (TALE), and CRISPR/Cas9 therapies to regulate gene expression are becoming viable strategies to treat genetic disorders, although effective in vivo delivery systems for these proteins remain a
Externí odkaz:
https://doaj.org/article/467d6e2aab3844e6b89d37a65f30a120
Autor:
Sunjay Sethi, Kimberly P. Keil Stietz, Anthony E. Valenzuela, Carolyn R. Klocke, Jill L. Silverman, Birgit Puschner, Isaac N. Pessah, Pamela J. Lein
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Polychlorinated biphenyls (PCBs) are putative environmental risks for neurodevelopmental disorders. Here, we tested two hypotheses: (1) developmental exposure to a human-relevant PCB mixture causes behavioral phenotypes relevant to neurodevelopmental
Externí odkaz:
https://doaj.org/article/b3ed7b2652ab4f929573d3ca75980c29
Autor:
Michelle Guignet, Kiran Dhakal, Brenna M. Flannery, Brad A. Hobson, Dorota Zolkowska, Ashish Dhir, Donald A. Bruun, Shuyang Li, Abdul Wahab, Danielle J. Harvey, Jill L. Silverman, Michael A. Rogawski, Pamela J. Lein
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
Current medical countermeasures for organophosphate (OP)-induced status epilepticus (SE) are not effective in preventing long-term morbidity and there is an urgent need for improved therapies. Rat models of acute intoxication with the OP, diisopropyl
Externí odkaz:
https://doaj.org/article/738218b0f62a47c78297d897468feddf
Autor:
Lucas Matt, Lyndsey M. Kirk, George Chenaux, David J. Speca, Kyle R. Puhger, Michael C. Pride, Mohammad Qneibi, Tomer Haham, Kristopher E. Plambeck, Yael Stern-Bach, Jill L. Silverman, Jacqueline N. Crawley, Johannes W. Hell, Elva Díaz
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2246-2253 (2018)
Summary: Altering AMPA receptor (AMPAR) content at synapses is a key mechanism underlying the regulation of synaptic strength during learning and memory. Previous work demonstrated that SynDIG1 (synapse differentiation-induced gene 1) encodes a trans
Externí odkaz:
https://doaj.org/article/22b1ceb0718049de9bca5dfd4fe626ec