A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity

Autor: Kazuki Tawaratsumida, Vanessa Redecke, Ruiqiong Wu, Jeeba Kuriakose, Jill J. Bouchard, Tanja Mittag, Brian K. Lohman, Ashutosh Mishra, Anthony A. High, Hans Häcker

Publikováno v: Science advances. 8(27)

Toll-like receptors (TLRs) recognize pathogen- and host-derived factors and control immune responses via the adaptor protein MyD88 and members of the interferon regulatory transcription factor (IRF) family. IRFs orchestrate key effector functions, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a7eb0e43d253d56740d8a3f0f27f49
https://pubmed.ncbi.nlm.nih.gov/35857476

Enhanced Sampling of Interdomain Motion Using Map-Restrained Langevin Dynamics and NMR: Application to Pin1

Autor: Jeffrey W. Peng, David A. Case, Junchao Xia, Jill J. Bouchard

Publikováno v: Journal of molecular biology. 430(14)

Many signaling proteins consist of globular domains connected by flexible linkers that allow for substantial domain motion. Because these domains often serve as complementary functional modules, the possibility of functionally important domain motion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6679733962a693a52d4b7da5f9f64cfb
https://pubmed.ncbi.nlm.nih.gov/29775635

Ensemble Interpretation of Domain Mobility in Modular Protein Pin1 by NMR and Molecular Dynamics

Autor: Jill J Bouchard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b016ade1337a3fbc74b17b8332ccc7

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.

Autor: Smith LK; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA. [3] Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, California, USA., He Y; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Park JS; 1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [2] Department of Biochemistry, Dankook University College of Medicine, Cheonan, Korea., Bieri G; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA. [3] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [4] Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California, USA., Snethlage CE; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA., Lin K; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA. [3] Neuroscience Graduate Program, University of California San Francisco, San Francisco, California, USA., Gontier G; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA., Wabl R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Plambeck KE; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA., Udeochu J; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA. [3] Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, California, USA., Wheatley EG; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA. [3] Developmental and Stem Cell Biology Graduate Program, University of California San Francisco, San Francisco, California, USA., Bouchard J; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA., Eggel A; Department of Rheumatology, Immunology and Allergology, University Hospital Bern, Bern, Switzerland., Narasimha R; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Grant JL; 1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [2] Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California, USA., Luo J; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Wyss-Coray T; 1] Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA. [2] Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California, USA. [3] Center for Tissue Regeneration, Repair and Restoration, Veterans' Affairs (VA) Palo Alto Health Care System, Palo Alto, California, USA., Villeda SA; 1] Department of Anatomy, University of California San Francisco, San Francisco, California, USA. [2] The Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, California, USA. [3] Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, California, USA. [4] Neuroscience Graduate Program, University of California San Francisco, San Francisco, California, USA. [5] Developmental and Stem Cell Biology Graduate Program, University of California San Francisco, San Francisco, California, USA. [6] California Institute for Quantitative Biosciences (QB3), San Francisco, California, USA.

Publikováno v: Nature medicine [Nat Med] 2015 Aug; Vol. 21 (8), pp. 932-7. Date of Electronic Publication: 2015 Jul 06.

Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease.

Autor: Bouchard J; Neuroscience Program, University of California San Francisco, California 94158, USA., Truong J, Bouchard K, Dunkelberger D, Desrayaud S, Moussaoui S, Tabrizi SJ, Stella N, Muchowski PJ

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2012 Dec 12; Vol. 32 (50), pp. 18259-68.