Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jill Henault"'
Autor:
Rachel Ettinger, Jodi L. Karnell, Jill Henault, Santosh K. Panda, Jeffrey M. Riggs, Roland Kolbeck, Miguel A. Sanjuan
Publikováno v:
Autoimmunity, Vol 50, Iss 1, Pp 25-36 (2017)
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their r
Externí odkaz:
https://doaj.org/article/ae21a14b0df746ca9389410b806f6814
Autor:
Jodi L. Karnell, Michael A Smith, William Rees, Victoria P. Werth, Jill Henault, Li Yan, Katherine Ann Vousden, Jeffrey M. Riggs, Miguel A. Sanjuan, Vib Trial Investigators, G. Illei, John N. Ratchford, Yanping Wu, Simone M. Nicholson, Kerry A. Casey, Nanette Mittereder, Michele Gunsior, Jorn Drappa
Publikováno v:
Science translational medicine. 13(595)
Plasmacytoid dendritic cells (pDCs) not only are specialized in their capacity to secrete large amounts of type I interferon (IFN) but also serve to enable both innate and adaptive immune responses through expression of additional proinflammatory cyt
Autor:
Dominic Sinibaldi, Ethan Grant, Rachel Ettinger, Melissa Parker, Michael A Smith, Kerry A. Casey, Michelle Petri, Devon K. Taylor, Miguel A. Sanjuan, Jodi L. Karnell, Jill Henault, Jeffrey M. Riggs, Roland Kolbeck
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Systemic lupus erythematosus (SLE) impacts multiple organ systems, although the causes of many individual SLE pathologies are poorly understood. This study was designed to elucidate organ-specific inflammation by identifying proteins that correlate w
Autor:
Jill Henault, Roland Kolbeck, Santosh K. Panda, Jeffrey M. Riggs, Rachel Ettinger, Jodi L. Karnell, Miguel A. Sanjuan
Publikováno v:
Autoimmunity. 50(1)
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their r
Autor:
Ronald Herbst, Tomas Mustelin, Marcus R. Clark, Lorraine Clarke, Deepak B. Khatry, Liat Izhak, Jill Henault, Kerry A. Casey, Michelle Petri, Rachel Ettinger, Lena Shirinian, Roland Kolbeck, Vladimir M. Liarski, Jodi L. Karnell, Linda Xu, Jeffrey M. Riggs, Miguel A. Sanjuan, Michael A Smith, Jianqing Li
Publikováno v:
Nature immunology. 17(2)
Canonically, immunoglobulin E (IgE) mediates allergic immune responses by triggering mast cells and basophils to release histamine and type 2 helper cytokines. Here we found that in human systemic lupus erythematosus (SLE), IgE antibodies specific fo
Publikováno v:
FEMS Immunology & Medical Microbiology. 47:138-147
Modulation of immune responses using Toll-like receptor (TLR) ligands is fast becoming one of the main new approaches for the treatment of infectious and allergic diseases. Characterizing the role of genetic factors in modulating responses to these l
Publikováno v:
Current opinion in immunology. 26
Noncanonical autophagy is utilized by phagocytes to kill and digest extracellular pathogens. This process is initiated at the cell surface by receptors that recruit elements of the autophagy machinery, like LC3, to the phagosome. Also known as LC3-as
Autor:
Miguel A. Sanjuan, Marcus R. Clark, Jill Henault, Vladimir M. Liarski, Roland Kolbeck, Ronald Herbst
Publikováno v:
Annals of the Rheumatic Diseases. 75:277.1-277
Background Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease, the most frequent severe manifestation of which is lupus nephritis (LuN). We have previously shown that tubulointerstitial inflammation (TII) is a usual feature of LuN wit
Autor:
Jeffrey M. Riggs, Kerry A. Casey, Ronald Herbst, Linda Xu, Michael A Smith, Jill Henault, Jodi L. Karnell, Roland Kolbeck, Rachel Ettinger, Lena Shirinian, Miguel A. Sanjuan, M. Petri, Marcus R. Clark, Deepak B. Khatry, Tomas Mustelin, Lorraine Clarke, Vladimir M. Liarski
Publikováno v:
Annals of the Rheumatic Diseases. 75:946.2-947
Background The discovery of Immunoglobulin E (IgE) nearly 40 years ago was a breakthrough in the field of allergy research. IgE directed against parasitic worms and allergens binds mast cells and basophils, triggering an inflammatory response that is
Autor:
Jane Tian, Douglas R. Green, Jennifer Martinez, Miguel A. Sanjuan, Payal Mehta, Jill Henault, Jeffrey M. Riggs, Akiko Iwasaki, Eicke Latz, Lorraine Clarke, Melanie M. Brinkmann, Anthony J. Coyle, Roland Kolbeck, Miwa Sasai
Publikováno v:
Immunity. 37(6)
SummaryToll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacyto