Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

Autor: Emma Sigfridsson, Martina Marangoni, Giles E. Hardingham, Karen Horsburgh, Jill H. Fowler

Publikováno v: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)

Abstract Background Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcri

Externí odkaz: https://doaj.org/article/7e3e2881787e4c44b3dfb9692b7f07a6

Neuronal Activity and Its Role in Controlling Antioxidant Genes

Autor: Jing Qiu, Owen Dando, James A. Febery, Jill H. Fowler, Siddharthan Chandran, Giles E. Hardingham

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 6, p 1933 (2020)

Forebrain neurons have relatively weak intrinsic antioxidant defenses compared to astrocytes, in part due to hypo-expression of Nrf2, an oxidative stress-induced master regulator of antioxidant and detoxification genes. Nevertheless, neurons do posse

Externí odkaz: https://doaj.org/article/e2cd306115fe4705a922f29b3a327afc

Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion.

Autor: Jamie McQueen, Michell M Reimer, Philip R Holland, Yasmina Manso, Mark McLaughlin, Jill H Fowler, Karen Horsburgh

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87227 (2014)

Chronic cerebral hypoperfusion, a sustained modest reduction in cerebral blood flow, is associated with damage to myelinated axons and cognitive decline with ageing. Oligodendrocytes (the myelin producing cells) and their precursor cells (OPCs) may b

Externí odkaz: https://doaj.org/article/2cb44815c5c14670820d6e19fbe5aa82

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings

Autor: Malcolm R. Macleod, Margaux Aimable, Scott Miners, Matthew MacGregor Sharp, Hilary V O Carswell, Philip M.W. Bath, Ashton Bernard, Emily S. Sena, Claire S. White, Rhian M. Touyz, Patrick G. Kehoe, Tracy D. Farr, Lorraine M. Work, Stefan Szymkowiak, Gillian L. Currie, Catherine N. Hall, Bettina Platt, Andrew N. Clarkson, Gaia Brezzo, Stuart M. Allan, Mark Andrew Good, Roxana O. Carare, Alison D. McNeilly, Alyson A. Miller, Jill H. Fowler, Barry W. McColl, Tuuli M Hietamies, Christopher McCabe, Rebecca C. Trueman, Vincent Mok, Rajesh N. Kalaria, Michael O'Sullivan, Terence J. Quinn, Karen Horsburgh, Atticus H. Hainsworth, Patrick Strangeward, Catherine E. Lawrence, Aisling McFall

Publikováno v: McFall, A, Hietamies, T M, Bernard, A, Aimable, M, Allan, S M, Bath, P M, Brezzo, G, Carare, R O, Carswell, H V, Clarkson, A N, Currie, G, Farr, T D, Fowler, J, Good, M, Hainsworth, A H, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, MacLeod, M, McNeilly, A, Miller, A A, Miners, S, Mok, V, O'Sullivan, M, Platt, B, Sena, E, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, R M, Trueman, R C, White, C, McCabe, C, Work, L M & Quinn, T J 2020, ' UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X20910552
Journal of Cerebral Blood Flow & Metabolism
McFall, A, Hietamies, T M, Bernard, A, Aimable, M, Allan, S M, Bath, P M, Brezzo, G, Carare, R O, Carswell, H V, Clarkson, A N, Currie, G, Farr, T D, Fowler, J H, Good, M, Hainsworth, A H, Hall, C, Horsburgh, K, Kalaria, R, Kehoe, P, Lawrence, C, Macleod, M, McColl, B W, McNeilly, A, Miller, A A, Miners, S, Mok, V, O'Sullivan, M, Platt, B, Sena, E S, Sharp, M, Strangeward, P, Szymkowiak, S, Touyz, R M, Trueman, R C, White, C, McCabe, C, Work, L M & Quinn, T J 2020, ' UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment : questionnaire and workshop proceedings ', Journal of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X20910552

Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine underlying variability and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eef0fbd3bfb3e2bea0c06634a444e02
https://strathprints.strath.ac.uk/71920/7/McFall_etal_JCBFM_2020_UK_consensus_on_pre_clinical_vascular_cognitive.pdf

Connecting to motor recovery after stroke

Autor: Raj N. Kalaria, Jill H. Fowler

Publikováno v: Brain Communications. 2

This scientific commentary refers to ‘Structural brain networks and functional motor outcome after stroke –a prospective cohort study’, by Schlemm et al. (https://doi.org/10.1093/braincomms/fcaa001) in Brain Communications and ‘Brain responsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b6b5230f971a916c3c136f14b5fbd1
https://doi.org/10.1093/braincomms/fcaa067