Výsledky vyhledávání - "Jill Farnsworth"

Akademický článek

Discovery and Synthesis of Hydroxy-l-Proline Blockers of the Neutral Amino Acid Transporters SLC1A4 (ASCT1) and SLC1A5 (ASCT2)

Autor: Brent R. Lyda, Gregory P. Leary, Jill Farnsworth, Benjamin Seaver, Derek Silvius, Michael P. Kavanaugh, C. Sean Esslinger, Nicholas R. Natale

Publikováno v: Molecules, Vol 29, Iss 10, p 2330 (2024)

As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors

Externí odkaz: https://doaj.org/article/09739a5a115743fe8c51173f32001947

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Akademický článek

D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures.

Autor: Alan C Foster, Jill Farnsworth, Genevieve E Lind, Yong-Xin Li, Jia-Ying Yang, Van Dang, Mahmud Penjwini, Veena Viswanath, Ursula Staubli, Michael P Kavanaugh

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0156551 (2016)

N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by eit

Externí odkaz: https://doaj.org/article/0fc9a259394b49028075712dc587e026

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Delta/Notch signaling in glia maintains motor nerve barrier function and synaptic transmission by controlling matrix metalloproteinase expression

Autor: Mario R. Calderon, Megumi Mori, Grant Kauwe, Jill Farnsworth, Suzana Ulian-Benitez, Elie Maksoud, Jordan Shore, A. Pejmun Haghighi

Publikováno v: Proceedings of the National Academy of Sciences. 119

While the role of barrier function in establishing a protective, nutrient-rich, and ionically balanced environment for neurons has been appreciated for some time, little is known about how signaling cues originating in barrier-forming cells participa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5602193c3183eaf77b682b654a0ca80c
https://doi.org/10.1073/pnas.2110097119

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Discovery and synthesis of hydroxy-L-proline based blockers of the neutral amino acid transporters SLC1A4 (ASCT1) and SLC1A5 (ASCT2)

Autor: Brent R. Lyda, Gregory P. Leary, Jill Farnsworth, Derek Silvius, Benjamin Seaver, C. Sean Esslinger, Nicholas R. Natale, Michael P. Kavanaugh

The conformationally restricted heterocycle hydroxy-L-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16821e2ba966c8cf06206d75570da98d
https://doi.org/10.1101/2021.12.14.470456

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