Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jill E Hunter"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract The product encoded by the X-linked inhibitor of apoptosis (XIAP) gene is a multi-functional protein which not only controls caspase-dependent cell death, but also participates in inflammatory signalling, copper homeostasis, response to hypo
Externí odkaz:
https://doaj.org/article/36168ae2c8b04b3fb7adce3cdb9a7444
Autor:
Sumit Sandhu, Ieng F. Sou, Jill E. Hunter, Lucy Salmon, Caroline L. Wilson, Neil D. Perkins, Neil Hunter, Owen R. Davies, Urszula L. McClurg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Sandhu et al. report that the synaptonemal complex (SC) protein, TEX12, localises to centrosomes independently of the SC during meiosis. They also show that it provokes centrosome amplification in somatic cells, a pathology associated with cancer dev
Externí odkaz:
https://doaj.org/article/d1221d134947415086c9e1e96900d10e
Autor:
Jill E. Hunter, Amy E. Campbell, Nicola L. Hannaway, Scott Kerridge, Saimir Luli, Jacqueline A. Butterworth, Helene Sellier, Reshmi Mukherjee, Nikita Dhillon, Praveen D. Sudhindar, Ruchi Shukla, Philip J. Brownridge, Hayden L. Bell, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Ian Collins, Michelle D. Garrett, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2063-2086
Previously, we discovered that deletion of c-Rel in the Eµ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report that Eµ-M
Autor:
Jill E. Hunter, Amy E. Campbell, Scott Kerridge, Callum Fraser, Nicola L. Hannaway, Saimir Luli, Iglika Ivanova, Philip J. Brownridge, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2131-2151
The development of resistance and the activation of bypass pathway signalling represents a major problem for the clinical application of protein kinase inhibitors. While investigating the effect of either a c-Rel deletion or RelAT505A phosphosite kno
Autor:
Jill E. Hunter, Amy E. Campbell, Jacqueline A. Butterworth, Helene Sellier, Nicola L. Hannaway, Saimir Luli, Achilleas Floudas, Niall S. Kenneth, Adam J. Moore, Philip J. Brownridge, Huw D. Thomas, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S.R. Hasoon, Andrew M. Knight, Michelle D. Garrett, Ian Collins, Claire E. Eyers, Neil D. Perkins
Publikováno v:
Biochemical Journal. 479:2087-2113
Autor:
Jill E Hunter, Oliver McHugh, Gabrielle B Ecclestone, Fraser Child, Hannah Mearns, Georgia Robson, Molly Dadzie, Sonia Rocha, Neil D Perkins, Niall S Kenneth
Adaptation to reduced oxygen availability is mediated by the hypoxia-inducible factor (HIF) family of transcription factors. The activity and availability of HIF proteins is primarily driven by the stability of the HIF alpha subunits. However, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21477b44379fc42e31ee1b732ec577a5
https://doi.org/10.1101/2022.11.02.514731
https://doi.org/10.1101/2022.11.02.514731
Autor:
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. The NF-κB transcription factor family subunit c-Rel is typically protumorigenic; however, it has recently been reported as a tumor suppressor. Here, we investigated the role
Publikováno v:
Oncogene. 42:546-547
Autor:
Suzanne Madgwick, Saimir Luli, Helene Sellier, Jacqueline A. Butterworth, Jack Leslie, Adam J. Moore, Emma K. Corbin, Adrian I. Yemm, Robson T. Chiremba, Dina Tiniakos, Fiona Oakley, Neil D. Perkins, Jill E. Hunter
Publikováno v:
The Biochemical journal. 479(19)
Claspin is an adaptor protein required for ATR-dependent phosphorylation of CHK1 during S-phase following DNA replication stress. Claspin expression is highly variable in cancer, with low levels frequently correlating with poor patient survival. To l
Autor:
Claire E. Eyers, Saimir Luli, Alan Campbell, Nicola L. Hannaway, Mukherjee R, Kerridge S, Garrett, Jill E. Hunter, Leary P, Hélène Sellier, Neil D. Perkins, Philip Brownridge, Jacqueline Butterworth, Ian Collins, Taylor L, Hasoon Ms, Jonathan Coxhead, Huw D. Thomas
We previously discovered that deletion of c-Rel in the Eμ-Myc mouse model of lymphoma results in earlier onset of disease, a finding that contrasted with the expected function of this NF-κB subunit in B-cell malignancies. Here we report that c-rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3707f3ad434a4000862fddaedcceed
https://doi.org/10.1101/2021.05.26.445425
https://doi.org/10.1101/2021.05.26.445425