Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jill Chrencik"'
Autor:
Brett D. Hollingshead, Fabien Vincent, Tsung H. Lin, John I. Trujillo, Betsy Pierce, Andrew Fensome, Brian S. Gerstenberger, Martin E. Dowty, Matthew Frank Brown, Xin Yang, David C. Limburg, Martin Hegen, John D. Knafels, Felix Vajdos, Andrew C. Flick, Mary Ellen Banker, Raman Sharma, Li Xing, Jason Jussif, Catherine M. Ambler, Ivan Viktorovich Efremov, James D. Clark, Liying Zhang, Peter T. Symanowicz, Eddine Saiah, Jill Chrencik, Jean-Baptiste Telliez, Xiaojing Yang, Eric P. Arnold, Ariamala Gopalsamy, Zhao-Kui Wan, Matthew Merrill Hayward, David W. Lin
Publikováno v:
Journal of Medicinal Chemistry. 61:8597-8612
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4f153dbb8b5bb68fb24a9742305143
https://doi.org/10.1021/acs.jmedchem.8b00917
https://doi.org/10.1021/acs.jmedchem.8b00917
Autor:
Andrew, Fensome, Catherine M, Ambler, Eric, Arnold, Mary Ellen, Banker, Matthew F, Brown, Jill, Chrencik, James D, Clark, Martin E, Dowty, Ivan V, Efremov, Andrew, Flick, Brian S, Gerstenberger, Ariamala, Gopalsamy, Matthew M, Hayward, Martin, Hegen, Brett D, Hollingshead, Jason, Jussif, John D, Knafels, David C, Limburg, David, Lin, Tsung H, Lin, Betsy S, Pierce, Eddine, Saiah, Raman, Sharma, Peter T, Symanowicz, Jean-Baptiste, Telliez, John I, Trujillo, Felix F, Vajdos, Fabien, Vincent, Zhao-Kui, Wan, Li, Xing, Xiaojing, Yang, Xin, Yang, Liying, Zhang
Publikováno v:
Journal of medicinal chemistry. 61(19)
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad2ad9462488003d246ff771f1250154
https://pubmed.ncbi.nlm.nih.gov/30113844
https://pubmed.ncbi.nlm.nih.gov/30113844
Autor:
Maureen K. Highkin, Matthew D. McReynolds, Matthew J. Saabye, John W. Rains, Kaliapan Iyanar, Jeffrey Carroll, Jill Chrencik, Matthew P. Yates, Jeffrey A. Scholten, Gina M. Jerome, Marek M. Nagiec, Mark E. Schnute
Publikováno v:
Journal of medicinal chemistry. 60(6)
Sphingosine kinase (SphK) is the major source of the lipid mediator and G protein-coupled receptor agonist sphingosine-1-phosphate (S1P). S1P promotes cell growth, survival, and migration and is a key regulator of lymphocyte trafficking. Inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c23d10cabd117ff2077923f1706da7
https://pubmed.ncbi.nlm.nih.gov/28231433
https://pubmed.ncbi.nlm.nih.gov/28231433
Autor:
Louis Leung, Jonathan Langille, John I. Trujillo, Paul B. Balbo, Jason Jussif, Jill Chrencik, Martin Hegen, Felix Vajdos, Atli Thorarensen, Sarah Soucy, Adam M. Gilbert, Jean-Baptiste Telliez, Tsung Lin, Ray Unwalla, Matthew Merrill Hayward, Justin I. Montgomery, Sidney Liang, Fabien Vincent, Robert M. Czerwinski, Ye Che, Martin E. Dowty, Mary Ellen Banker, Xin Yang, Matthew Frank Brown, Agustin Casimiro-Garcia, Jotham Wadsworth Coe, Brian Juba
Publikováno v:
Journal of medicinal chemistry. 60(5)
Significant work has been dedicated to the discovery of JAK kinase inhibitors resulting in several compounds entering clinical development and two FDA approved NMEs. However, despite significant effort during the past 2 decades, identification of hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5195e7072387df8494062118b596b7
https://pubmed.ncbi.nlm.nih.gov/28139931
https://pubmed.ncbi.nlm.nih.gov/28139931
Autor:
Iain Kilty, Yogesh A. Sabnis, Paul Morgan, Jill Chrencik, Florian Wakenhut, John Murphy, Jotham Wadsworth Coe, Katherine S. England, Takasuke Mukaiyama, David G. Brown, Rhys M. Jones, Thean Yeoh, R. Ian Storer, Gavin A. Whitlock, Christoph Martin Dehnhardt, Peter Jones, Steve Kortum
Publikováno v:
Journal of medicinal chemistry. 60(2)
By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP binding site, a potent series of indazoles was identified as selective pan-JAK inhibitors with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9eceea782db079496a087ef33c246a
https://pubmed.ncbi.nlm.nih.gov/27983835
https://pubmed.ncbi.nlm.nih.gov/27983835
Autor:
Michelle Kraus, Jay M. Wendling, Olga V. Nemirovskiy, John W. Rains, Vincent Peterkin, Laura E. Zawadzke, Hideji Fujiwara, Ciarán N. Cronin, Troii Hall, Tom Kasten, Maureen K. Highkin, Gina M. Jerome, Arthur J. Wittwer, Matthew P. Yates, Shinji Ogawa, Jeffrey A. Scholten, Jill Chrencik, Marek M. Nagiec, Matthew D. McReynolds, Kaliapan Iyanar, Mark E. Schnute, Kristin Cukyne, Matthew J. Saabye, Richard M. Broadus
Publikováno v:
Biochemical Journal. 444:79-88
SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29039f87435103ee01d57e1663842f
https://doi.org/10.1042/bj20111929
https://doi.org/10.1042/bj20111929
Autor:
James R. Kiefer, Joseph W. Leone, Alfredo G. Tomasselli, Robin A. Weinberg, Akshay Patny, H. David Fischer, Cynthia D. Sommers, Jennifer A. Gormley, Timothy E. Benson, Horng-Chih Huang, E.J. Jacobsen, Jacqueline E. Day, Thomas L. Emmons, Jill Chrencik, Iris K. Leung, Jeffrey L. Hirsch, Tenbrink Ruth E, Jennifer M. Williams, Brian Korniski, Troii Hall
Publikováno v:
Journal of Molecular Biology. 400:413-433
Janus kinases (JAKs) are critical regulators of cytokine pathways and attractive targets of therapeutic value in both inflammatory and myeloproliferative diseases. Although the crystal structures of active JAK1 and JAK2 kinase domains have been repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b19fab0c9dc63112be2b1f9f66fc065
https://doi.org/10.1016/j.jmb.2010.05.020
https://doi.org/10.1016/j.jmb.2010.05.020
Autor:
Thomas L. Emmons, Alfredo G. Tomasselli, Robin A. Weinberg, H. David Fischer, Jill Chrencik, Brian Korniski, Jacqueline E. Day, Stacy Brown, Joseph W. Leone, Ann D. Wrightstone, Cynthia D. Sommers, Jeffrey L. Hirsch, Arthur J. Wittwer, Troii Hall, Jennifer A. Gormley
Publikováno v:
Biochemical and Biophysical Research Communications. 396:543-548
The Janus kinase family consists of four members: JAK-1, -2, -3 and TYK-2. While JAK-2 and JAK-3 have been well characterized biochemically, there is little data on TYK-2. Recent work suggests that TYK-2 may play a critical role in the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4568dae04b1e101103ca4b31d2d17487
https://doi.org/10.1016/j.bbrc.2010.04.141
https://doi.org/10.1016/j.bbrc.2010.04.141
Autor:
Thomas L. Emmons, James R. Kiefer, Joseph W. Leone, John F. Schindler, Melissa S. Harris, Jacqueline E. Day, Siradanahalli Guru, Alfredo G. Tomasselli, Robin A. Weinberg, Sandra Lightle, H. David Fischer, Jeffrey L. Hirsch, Jill Chrencik, Jennifer A. Gormley, Jennifer M. Williams, Matthew J. Saabye, Troii Hall
Publikováno v:
Protein Expression and Purification. 69:54-63
Janus-associated kinases (JAKs) play critical roles in cytokine signaling, and have emerged as viable therapeutic targets in inflammation and oncology related diseases. To date, targeting JAK proteins with highly selective inhibitor compounds have re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68adb1eba9066345bc1000db1eef31a2
https://doi.org/10.1016/j.pep.2009.09.011
https://doi.org/10.1016/j.pep.2009.09.011
Autor:
James R. Kiefer, D.H. Fischer, Jennifer M. Williams, Huey-Sheng Shieh, Jill Chrencik, Nicole Caspers, Adele M. Pauley, Alfredo G. Tomasselli, Jacqueline E. Day, Troii Hall, Lyle E. Pegg, J.M. Krahn, A.F. Moon, Zack
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 6)
The role of ADAM-8 in cancer and inflammatory diseases such as allergy, arthritis and asthma makes it an attractive target for drug development. Therefore, the catalytic domain of human ADAM-8 was expressed, purified and crystallized in complex with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e846fdf764689822bfa60e94c8be7e80
https://pubmed.ncbi.nlm.nih.gov/22684055
https://pubmed.ncbi.nlm.nih.gov/22684055