Výsledky vyhledávání - "Jill C. Pelling"

Data from Dietary Genistein Inhibits Metastasis of Human Prostate Cancer in Mice

Autor: Raymond C. Bergan, Jill C. Pelling, Irene Helenowski, Chris H. Takimoto, Joshua Cooper, Vijayalakshmi Ananthanarayanan, Li Xu, Minalini Lakshman

Dietary genistein has been linked to lower prostate cancer (PCa) mortality. Metastasis is the ultimate cause of death from PCa. Cell detachment and invasion represent early steps in the metastatic cascade. We had shown that genistein inhibits PCa cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::817cdd5c4f50966456f8c0f62ddb3e5d
https://doi.org/10.1158/0008-5472.c.6497531

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Akademický článek

The desmosomal armadillo protein plakoglobin regulates prostate cancer cell adhesion and motility through vitronectin-dependent Src signaling.

Autor: Carrie A Franzen, Viktor Todorović, Bhushan V Desai, Salida Mirzoeva, Ximing J Yang, Kathleen J Green, Jill C Pelling

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42132 (2012)

Plakoglobin (PG) is an armadillo protein that associates with both classic and desmosomal cadherins, but is primarily concentrated in mature desmosomes in epithelia. While reduced levels of PG have been reported in localized and hormone refractory pr

Externí odkaz: https://doaj.org/article/a9615b5051984a3fa939fd60d7247c2d

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Inhibition of mTOR by apigenin in UVB-irradiated keratinocytes: A new implication of skin cancer prevention

Autor: Olga V. Volpert, Jill C. Pelling, Bryan B. Bridgeman, Pu Wang, Xin Tong, Boping Ye

Publikováno v: Cellular Signalling. 28:460-468

Ultraviolet B (UVB) radiation is the major environmental risk factor for developing skin cancer, the most common cancer worldwide, which is characterized by a berrant activation of Akt/mTOR (mammalian target of rapamycin). Importantly, the link betwe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d794612803be599d117de66900c0b1
https://doi.org/10.1016/j.cellsig.2016.02.008

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Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1

Autor: Salida Mirzoeva, Xin Tong, Philip Fitchev, Mona Cornwell, Olga V. Volpert, Susan E. Crawford, Dorina Veliceasa, Jill C. Pelling, Bryan B. Bridgeman

Publikováno v: Oncotarget

Plant flavonoid apigenin prevents and inhibits UVB-induced carcinogenesis in the skin and has strong anti-proliferative and anti-angiogenic properties. Here we identify mechanisms, by which apigenin controls these oncogenic events. We show that apige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a13c4c72acceaeabc591bb010faf65
https://doi.org/10.18632/oncotarget.2551

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Apigenin inhibits TGF-β-induced VEGF expression in human prostate carcinoma cells via a Smad2/3- and Src-dependent mechanism

Autor: Salida Mirzoeva, Jill C. Pelling, Carrie A. Franzen

Publikováno v: Molecular Carcinogenesis. 53:598-609

Cancer progression relies on establishment of the blood supply necessary for tumor growth and ultimately metastasis. Prostate cancer mortality is primarily attributed to development of metastases rather than primary, organ-confined disease. Vascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e79ce77145d7e719d0e59955e4b3cb7
https://doi.org/10.1002/mc.22005

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UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes

Autor: Kimberly A. Smith, Jill C. Pelling, Cara J. Gottardi, Adnan O. Abu-Yousif, Xin Tong, Carol Mikulec, Susan M. Fischer

Publikováno v: Molecular Carcinogenesis. 51:734-745

UVB radiation is the major carcinogen responsible for skin carcinogenesis, thus elucidation of the molecular pathways altered in skin in response to UVB would reveal novel targets for therapeutic intervention. It is well established that UVB leads to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4a7dc86bd8a9a76b380dddd3434bcd4
https://doi.org/10.1002/mc.20840

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Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes

Autor: Jill C. Pelling, Xin Tong, Kimberly A. Smith

Publikováno v: Molecular Carcinogenesis. 51:268-279

AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e284d2d1af86c777c45239cbae523d95
https://doi.org/10.1002/mc.20793

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The Chemopreventive Bioflavonoid Apigenin Inhibits Prostate Cancer Cell Motility through the Focal Adhesion Kinase/Src Signaling Mechanism

Autor: Carrie A. Franzen, Teng Leong Chew, Jill C. Pelling, Kathleen J. Green, Evangeline V. Amargo, Viktor Todorović, Bartosz A. Grzybowski, Sabil Huda, Salida Mirzoeva, Bhushan V. Desai, Karen Chiu

Publikováno v: Cancer Prevention Research. 2:830-841

Prostate cancer mortality is primarily attributed to metastatic rather than primary, organ-confined disease. Acquiring a motile and invasive phenotype is an important step in development of tumors and ultimately metastasis. This step involves remodel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f152a729fb5835b1612361658ecdf856
https://doi.org/10.1158/1940-6207.capr-09-0066

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Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells

Autor: Raymond C. Bergan, Salida Mirzoeva, Karen Chiu, Jill C. Pelling, Carrie A. Franzen, Nam Deuk Kim

Publikováno v: Molecular Carcinogenesis. 47:686-700

Progression of cancer leads to hypoxic solid tumors that mount specific cell signaling responses to low oxygen conditions. An important objective of anti-cancer therapy is the development of new drugs that suppress hypoxic responses in solid tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c415c406d0b30c41d7e25386839a52
https://doi.org/10.1002/mc.20421

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