Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jill Beierle"'
Autor:
Jill Beierle, Marquerita Algorri, Marisol Cortés, Nina S. Cauchon, Andrew Lennard, J. Paul Kirwan, Shirley Oghamian, Michael J. Abernathy
Publikováno v:
AAPS Open, Vol 9, Iss 1, Pp 1-19 (2023)
Abstract Innovation in pharmaceutical therapeutics is critical for the treatment of serious diseases with unmet medical need. To accelerate the approval of these innovative treatments, regulatory agencies throughout the world are increasingly adoptin
Externí odkaz:
https://doaj.org/article/19d08cd8efe8483e9d34b901f4538df4
Autor:
Michael J. Abernathy, Mike McGorry, Nina Cauchon, Jill Beierle, Sheetal Gaiki, Kathleen Sugrue-Richards, Gang Xue, Pradeep Mady, Andrew Lennard, David Cronin, Kabir Ahluwalia
Publikováno v:
Journal of pharmaceutical sciences. 111(5)
Recent advancements in data engineering, data science, and secure cloud storage can transform the current state of global Chemistry, Manufacturing, and Controls (CMC) regulatory activities to automated online digital processes. Modernizing regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977e6abb52d263c181b1c72b20aea74b
https://pubmed.ncbi.nlm.nih.gov/34610323
https://pubmed.ncbi.nlm.nih.gov/34610323
Autor:
Gerd R. Kleemann, Thomas M. Dillon, Jill Beierle, Pavel V. Bondarenko, Andrew C. Nichols, Gary D. Pipes
Publikováno v:
Analytical Chemistry. 80:2001-2009
A combinatory approach for the characterization of post-translational and chemical modifications in high molecular weight therapeutic proteins like antibodies and peptide-Fc fusion proteins (MWor = 50 000 Da) is presented. In this approach, well-esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2898380b777dafcb5bfcbefd46bf90c9
https://doi.org/10.1021/ac701629v
https://doi.org/10.1021/ac701629v
Autor:
Wen Yu, Scott D. Patterson, Jessica Mort, Michael D. McGinley, Chris Spahr, Jill Beierle, Michael T. Davis, John H. Robinson, Edward T. Bures, Roland Luethy
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 752:281-291
A simple multidimensional liquid chromatography system utilizing an isocratic pump and a HPLC system is described for the comprehensive proteomic analysis of complex peptide digest mixtures by coupled LC-LC-MS-MS techniques. A binary ion-exchange sep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80328ad4e9d14dfe142f76e67d3916e
https://doi.org/10.1016/s0378-4347(00)00547-8
https://doi.org/10.1016/s0378-4347(00)00547-8
Autor:
Michael D. McGinley, Chris Spahr, John H. Robinson, Michael T. Davis, Edward J. Bures, Wen Yu, Roland Luethy, Scott D. Patterson, Jessica Mort, Jill Beierle
Publikováno v:
PROTEOMICS. 1:108-117
With an emphasis on obtaining a multitude of high quality tandem mass spectrometry spectra for protein identification, instrumental parameters are described for the liquid chromatography-tandem mass spectrometry analysis of trypsin digested unfractio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ed0e365934f4be216dd1c06fbe1763c
https://doi.org/10.1002/1615-9861(200101)1:1<108::aid-prot108>3.0.co
https://doi.org/10.1002/1615-9861(200101)1:1<108::aid-prot108>3.0.co
Autor:
Edward J. Bures, John H. Robinson, Michael D. McGinley, Chris Spahr, Jessica Mort, Michael T. Davis, Kui Chen, Robert C. Wahl, Jill Beierle, Wen Yu, Scott D. Patterson, Paul L. Courchesne, Roland Luethy
Publikováno v:
PROTEOMICS. 1:93-107
The proteome of normal male urine from a commercial pooled source has been examined using direct liquid chromatography-tandem mass spectrometry (LC-MS/MS). The entire urinary protein mixture was denatured, reduced and enzymatically digested prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::171153532d83cf18dc664d509cae13e4
https://doi.org/10.1002/1615-9861(200101)1:1<93::aid-prot93>3.0.co
https://doi.org/10.1002/1615-9861(200101)1:1<93::aid-prot93>3.0.co
Autor:
Edward J. Bures, Michael T. Davis, Scott D. Patterson, Jessica Mort, Jill Beierle, Michael D. McGinley, Chris Spahr, John H. Robinson
Publikováno v:
Electrophoresis. 21:1678-1684
A simplified device and procedure have been developed for microcapillary gradient liquid chromatography-tandem mass spectrometry (LC-MS/MS). This procedure has proved useful in identifying low level quantities of proteins from sodium dodecyl sulfate-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28cfbb1e812935c99c3162ed812f1890
https://doi.org/10.1002/(sici)1522-2683(20000501)21:9<1678::aid-elps1678>3.0.co
https://doi.org/10.1002/(sici)1522-2683(20000501)21:9<1678::aid-elps1678>3.0.co
Autor:
Michael J. Treuheit, Pavel V. Bondarenko, Gayathri Ratnaswamy, Da Ren, David N. Brems, Jill Beierle
Publikováno v:
International journal of biological macromolecules. 44(1)
The following analytical methods have been used to identify and quantify degradation products in an E. coli expressed human immunoglobulin G Fc fusion protein in both liquid and lyophilized forms: two-dimensional AEX/RP/MS, limited proteolysis follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5140c2520da60822d652d7a543159a04
https://pubmed.ncbi.nlm.nih.gov/19014964
https://pubmed.ncbi.nlm.nih.gov/19014964