Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jill A. Trendel"'
Autor:
Jared R Mayo, Donghyun Kim, Jill A. Trendel, Divya Andy, Paul W. Erhardt, Benjamin Heck, Jeffery T Farris, Jeffrey G. Sarver, Brian Kress, Bruce E. Heck
Publikováno v:
Journal of medicinal chemistry. 64(10)
We synthesized a directed library of compounds to explore the structure-activity relationships of peroxisome proliferator-activated receptor δ (PPARδ) activation relative to mesenchymal stem cell (MSC) osteogenesis. Our scaffold used para-substitut
Autor:
Susan F. Slovin, David M. Nanus, Cathryn H. Bock, Daniel J. George, Chuck Strand, Jack David Marcus, Virgil H Simons, Jill A Trendel, Zachery R. Reichert, Celestia S. Higano, Lorelei A. Mucci, Christos Kyriakopoulos, Elisabeth I. Heath, Crawford Johnson, Shannon Lory
Publikováno v:
Clinical Genitourinary Cancer. 17:161-168
Autor:
A. J. Kinzler, M. M. Vaughan, Paul W. Erhardt, Z. Zhang, Jill A. Trendel, Jeffrey G. Sarver, Z. A. Prokopiak, N. J. Dafoe
Publikováno v:
Biologia plantarum. 60:724-730
Cytochrome P450, CYP93A1, is involved in the synthesis of the phytoalexin glyceollin in soybean (Glycine max L. Merr). The gene encoding CYP93A1 has been used as defense marker in soybean cell cultures, however, little is known regarding how this gen
Publikováno v:
Journal of cancer therapy
Ovarian cancer is the gynecological cancer with the poorest prognosis. One significant reason is the development of resistance to the chemotherapeutic drugs used in its treatment. The large GTPase, hGBP-1, has been implicated in paclitaxel resistance
Autor:
Jill A. Trendel
Publikováno v:
Expert Opinion on Drug Discovery. 8:1491-1501
Prostate cancer is the second most common cancer death in men after lung cancer, due to distant metastases. While distant prostate cancer is typically castrate resistant, it is not necessarily androgen independent. For this reason, a review of the li
Autor:
John P. Wilson, Geoffrey O. Nyabuto, Travis Mazur, Aaron R. Tipton, Jacob S. Justinger, Deborah J. Vestal, Jill A. Trendel, Peter T. Nguyen, Suzan Wadi, Garret L. Moore
Forced expression of the cytokine-induced large GTPase, human Guanylate-Binding Protein-1 (hGBP-1), in ovarian cancer cell lines increases resistance to paclitaxel. Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfa0aaa6cee7b2e464c73e6c434a08b
https://europepmc.org/articles/PMC5030188/
https://europepmc.org/articles/PMC5030188/
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
This chapter offers a review of the historical and present-day design and development of prodrugs. Several case studies are presented to further illustrate the principles being discussed. Keywords: ADMET; drug design; esterase; prodrugs
Autor:
Paul W. Erhardt, Wieslaw A. Klis, Jill A. Trendel, Crystal Bykowski, Mugunthu R. Dhananjeyan, Jeffrey G. Sarver, Michael D. Reese, Nicole Ellis
Publikováno v:
SLAS Discovery. 13:804-809
Peptidylglycine alpha-amidating monooxygenase (PAM) converts inactive terminal-glycine prohormones into their activated alpha-amidated forms. PAM is thought to play a role in the development of antiandrogen drug resistance in prostate cancer (CaP) th
Autor:
Crystal Bykowski, Paul W. Erhardt, Howard Ando, Mugunthu R. Dhananjeyan, Jeffrey G. Sarver, Jill A. Trendel
Publikováno v:
Journal of Chromatography B. 847:224-230
A sensitive high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method has been developed for simultaneous determination of procaine and its metabolite p-aminobenzoic acid (PABA). N-Acetylprocainamide (NAPA) was used as an inte
Autor:
Jidong Liu, Paul W. Erhardt, Crystal Bykowski, Howard Ando, Mugunthu R. Dhananjeyan, Jill A. Trendel, Jeffrey G. Sarver
Publikováno v:
Journal of Chromatography A. 1138:101-108
A rapid high-performance liquid chromatography method has been developed for simultaneous determination of capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine (5'-DFCR), 5'-deoxy-5-fluorouridine (5'-DFUR) and 5-fluorouracil (5-FU). 5'-DFCR wa