Výsledky vyhledávání - "Jill A. Hart"

L-trans-2,3-Pyrrolidine Dicarboxylate: Characterization of a Novel Excitotoxin

Autor: C L Willis, Richard J. Bridges, T Blakely, Hans P. Koch, C.A Baker, M Kadri, Humphrey John Michael, A R Chamberlin, S Shim, Jill A. Hart, L Ralston

Publikováno v: Neuropharmacology. 35:531-539

This study investigated the in vitro and in vivo excitotoxic properties of a novel conformationally constrained analogue of L-trans-2,3-pyrrolidine dicarboxylate (L-trans-2,3-PDC). When tested for excitotoxic activity in rat cortical cultures, L-tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0eb86acff1dcb89aa3bf657b649873
https://doi.org/10.1016/0028-3908(96)84623-5

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Efficient syntheses of diastereoselectively labeled (3S)-[4-13C]-l-valine, and regioselectively labeled [3-13CH3]-l-isoleucine hydrochlorides

Autor: A. Richard Chamberlin, Jill A. Hart, Humphrey John Michael

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1315-1320

Diastereoselectively labeled (3S)-[4-13C]-l-valine and regioselectively labeled [3-13CH3]-l-isoleucine hydrochlorides were synthesized in 54% and 62% respective overall yields from l-aspartic acid.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3df5de93fc589d0d5989eab771053c58
https://doi.org/10.1016/0960-894x(95)00214-e

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2,3-Pyrrolidinedicarboxylates as Neurotransmitter Conformer Mimics: Enantioselective Synthesis via Chelation-Controlled Enolate Alkylation

Autor: Jill A. Hart, Humphrey John Michael, A. Richard Chamberlin, Richard J. Bridges

Publikováno v: The Journal of Organic Chemistry. 59:2467-2472

Conformationally restricted analogs of naturally-occurring amino acids can serve in a variety of ways as protein structure/function probes. A diastereo- and enantioselective synthesis of the four stereoisomers of 2,3-pyrrolidinedicarboxylic acid (an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff1ebefbcefbb70ec54651b87f250a7c
https://doi.org/10.1021/jo00088a030

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Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

Autor: John L. Butenhoff, Maria Sundström, David J. Ehresman, Jill A. Hart, Gregory S. Gorman, Shu-Ching Chang, Patricia E. Noker, Åke Bergman

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 33(4)

Perfluorooctanesulfonate (PFOS) has been found in biological samples in wildlife and humans. The geometric mean half-life of serum elimination of PFOS in humans has been estimated to be 4.8 years (95% CI, 4.0-5.8). A series of studies was undertaken

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ea4b7b02826f28cb855c939d34f316
https://pubmed.ncbi.nlm.nih.gov/21856411

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Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys

Autor: Shu-Ching Chang, Patricia E. Noker, Gregory S. Gorman, Sheila J. Gibson, Jill A. Hart, David J. Ehresman, John L. Butenhoff

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 33(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848022e22fc5c9e40bf00bcaaf758aa9
https://pubmed.ncbi.nlm.nih.gov/21889587

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Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water

Autor: Patricia E. Noker, Shu-Ching Chang, David J. Ehresman, Mark E. Ellefson, Geary W. Olsen, Paul H. Lieder, Christopher Lau, Yu-Mei Tan, Jill A. Hart, Kaberi P. Das, John L. Butenhoff, Gregory S. Gorman

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 104(1)

Perfluorobutyrate (PFBA) has been detected in precipitation, surface waters, water treatment effluent, and in public and private wells in Minnesota at up to low microg/l concentrations. We evaluated the pharmacokinetics of PFBA in rats, mice, monkeys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3406ba08a6e63df53bfd8de96d30023c
https://pubmed.ncbi.nlm.nih.gov/18353799

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