Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jill A. Franzosa"'
Autor:
Jill A. Franzosa, Jessica A. Bonzo, John Jack, Nancy C. Baker, Parth Kothiya, Rafal P. Witek, Patrick Hurban, Stephen Siferd, Susan Hester, Imran Shah, Stephen S. Ferguson, Keith A. Houck, John F. Wambaugh
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays
Externí odkaz:
https://doaj.org/article/650b871553ac4893ba69a76c57d0eaab
Autor:
Kristin K. Isaacs, Jonathan T. Wall, Katie Paul Friedman, Jill A. Franzosa, Helen Goeden, Antony J. Williams, Kathie L. Dionisio, Jason C. Lambert, Monica Linnenbrink, Amar Singh, John F. Wambaugh, Alexander R. Bogdan, Christopher Greene
Publikováno v:
Journal of Exposure Science & Environmental Epidemiology.
Autor:
Anne H. Chappelle, Kimberly W. White, Donna L. Mendrick, Linda S. Birnbaum, Laurie C. Haws, Suzanne Fitzpatrick, K. Nadira De Abrew, Katerine S. Saili, Jill A Franzosa, Thomas B. Knudsen, Susan Y. Euling, Alison Elder, George P. Daston, Nicole Kleinstreuer, Alexandra Turley, Ruthann A. Rudel, Dana C. Dolinoy, Elaine M. Faustman, Germaine M. Buck Louis, Thaddeus T. Schug, Todd J. Zurlinden, Robyn L Tanguay, Barbara A. Wetmore, Derik E. Haggard, Kristi Pullen Fedinick
Publikováno v:
Toxicol Sci
FutureTox IV, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2018. Building upon FutureTox I, II, and III, this conference focused on the latest science and technology for in vitro profiling and in silico m
Autor:
Barbara D. Abbott, David G. Belair, Nisha S. Sipes, Nancy C. Baker, Thomas B. Knudsen, Richard S. Judson, Jill A Franzosa
Publikováno v:
Birth Defects Res
Cleft palate has been linked to both genetic and environmental factors that perturb key events during palatal morphogenesis. As a developmental outcome, it presents a challenging, mechanistically complex endpoint for predictive modeling. A data set o
Autor:
Menghang Xia, Robert G. Ellis-Hutchings, Jill A Franzosa, Nancy C. Baker, Edward W. Carney, Todd J. Zurlinden, Raja S. Settivari, Thomas B. Knudsen, Richard M. Spencer, Katerine S. Saili, Nicole Kleinstreuer, Shuaizhang Li
Publikováno v:
Curr Opin Toxicol
The more than 80,000 chemicals in commerce present a challenge for hazard assessments that toxicity testing in the 21(st) century strives to address through high-throughput screening (HTS) assays. Assessing chemical effects on human development adds
Autor:
Stephen S. Ferguson, Parth Kothiya, Stephen Siferd, Imran Shah, Jessica A. Bonzo, John F. Wambaugh, John Jack, Rafal P. Witek, Susan D. Hester, Keith A. Houck, Jill A Franzosa, Patrick Hurban, Nancy C. Baker
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-15 (2021)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
The ToxCast in vitro screening program has provided concentration-response bioactivity data across more than a thousand assay endpoints for thousands of chemicals found in our environment and commerce. However, most ToxCast screening assays have eval
Autor:
Panagiotis G. Karamertzanis, Jill A Franzosa, Ann M. Richard, Jean-Lou Dorne, Stiven Foster, Katie Paul Friedman, Lit-Hsin Loo, Jason C. Lambert, Tomasz Sobanski, Kathleen Raffaele, Andrea Gissi, Ryan Lougee, Maureen R. Gwinn, Matthew Gagne, Mike Rasenberg, T. I. Netzeva, Tina Bahadori, Michelle M. Angrish, Tara S. Barton-Maclaren, Maurice Whelan, Russell S. Thomas, Jia-Ying Joey Lee
Publikováno v:
Toxicol Sci
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the potential to accelerate the pace of human health safety evaluation by informing screening-level assessments. The primary objective of this work was to com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7dcece133ad478c7ce9fa2912e2fcf
https://europepmc.org/articles/PMC7720780/
https://europepmc.org/articles/PMC7720780/
Autor:
Keith A. Houck, Jill A Franzosa, Seth W. Kullman, Kyle R. Roell, Debabrata Mahapatra, David M. Reif, Denis Fourches, Mélaine A. Kuenemann
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
High throughput screening (HTS) programs have demonstrated that the Vitamin D receptor (VDR) is activated and/or antagonized by a wide range of structurally diverse chemicals. In this study, we examined the Tox21 qHTS data set generated against VDR f
Autor:
Thomas B. Knudsen, Raja S. Settivari, Alene T. McCoy, Jill A Franzosa, Edward W. Carney, Robert G. Ellis-Hutchings, Nicole Kleinstreuer
Embryonic vascular disruption is an important adverse outcome pathway (AOP) as chemical disruption of cardiovascular development induces broad prenatal defects. High throughput screening (HTS) assays aid AOP development although linking in vitro data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3cbe61957d8a1ab74cb657b8da3bcd
https://europepmc.org/articles/PMC6706853/
https://europepmc.org/articles/PMC6706853/
Autor:
Robert L. Tanguay, Susan C. Tilton, Sean M. Bugel, Katrina M. Waters, Jane K. La Du, Jill A. Franzosa, Tamara Tal
Publikováno v:
The FASEB Journal. 27:4866-4876
Retinoic acid (RA) is involved in multifarious and complex functions necessary for vertebrate development. RA signaling is reliant on strict enzymatic regulation of RA synthesis and metabolism. Improper spatiotemporal expression of RA during developm